73963-62-9
CAS
BiologicalState705
Homo sapiens, Platelet
Endoplasmic Reticulum Membrane
937
ChemSpider
Platelet
direct_interaction
CHEBI:31401
ChEBI
AMP
BioCyc
SMILES
O
Cytochrome P450 3A4
93632-84-9
CAS
4-cis-Hydroxy cilostazol
C10H14N5O7P
Adenosine monophosphate
347.06308
10045635
PubChem-compound
CHEBI:16027
ChEBI
Cytochrome P450 3A4
Q08499
UniProt
ReactionCatalysis170206
ACTIVATION
Cytochrome P450 3A5
Water
ReactionCatalysis170208
ACTIVATION
ReactionCatalysis170207
ACTIVATION
1.0
BTO:0001102
BRENDA TISSUE ONTOLOGY
C10H12N5O6P
cAMP
329.05252
P33261
UniProt
cAMP
BTO:0000759
BRENDA TISSUE ONTOLOGY
10022985
PubChem-compound
PW000289
PathWhiz
Homo sapiens
ReactionCatalysis170215
ACTIVATION
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
1038
PubChem-compound
7732-18-5
CAS
87153-06-8
CAS
C00575
KEGG Compound
61-19-8
CAS
SMILES
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
GO:0005789
GENE ONTOLOGY
Reaction180351
false
Cilostazol → 4-cis-Hydroxy cilostazol
LEFT_TO_RIGHT
Reaction180350
false
Cilostazol → 4-Hydroxycilostazol
LEFT_TO_RIGHT
Reaction180353
false
4-cis-Hydroxy cilostazol ↔ 4'-trans-Hydroxycilostazol
REVERSIBLE
Reaction180352
false
4-Hydroxycilostazol → 3,4-Dehydrocilostazol
LEFT_TO_RIGHT
SMP0000263
SMPDB
C20H27N5O2
Cilostazol
369.21646
1.0
5858
ChemSpider
BiologicalState10
Homo sapiens, Liver
2754
PubChem-compound
CL:0000233
CELL TYPE ONTOLOGY
5851
ChemSpider
1010
ChemSpider
Cytochrome P450 2C19
1.0
Interaction2946
3,4-Dehydrocilostazol inhibits cAMP-specific 3',5'-cyclic phosphodiesterase 4D
HMDB0000045
HMDB
Interaction2947
4'-trans-Hydroxycilostazol inhibits cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Cytochrome P450 2C19
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O
P20815
UniProt
1.0
9606
TAXONOMY
SMILES
O=C1CCC2=C(N1)C=CC(OCCCCC1=NN=NN1C1CCCCC1)=C2
962
PubChem-compound
2652
ChemSpider
Hydrogen Ion
Cytochrome P450 3A5
C00080
KEGG Compound
HMDB0000058
HMDB
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
GO:0005886
GENE ONTOLOGY
HMDB0002111
HMDB
Cell Membrane
CHEBI:15377
ChEBI
1.0
CHEBI:15378
ChEBI
SMILES
[H+]
P08684
UniProt
1.0
10021885
PubChem-compound
C00001
KEGG Compound
73963-72-1
CAS
3,4-Dehydrocilostazol
Liver
1.0
Cilostazol
4'-trans-Hydroxycilostazol
Reaction180360
false
Water + cAMP → Adenosine monophosphate + Hydrogen Ion
LEFT_TO_RIGHT
CHEBI:17489
ChEBI
3,4-Dehydrocilostazol
4'-trans-Hydroxycilostazol
6083
PubChem-compound
CAMP
BioCyc
4-Hydroxycilostazol
87153-04-6
CAS
1.0
Blood Vessel
H2O
Water
18.010565
C20H27N5O3
4'-trans-Hydroxycilostazol
385.2114
C20H27N5O3
4-cis-Hydroxy cilostazol
385.2114
BiologicalState51
Homo sapiens, Blood Vessel
C20H25N5O2
3,4-Dehydrocilostazol
367.20084
C20H27N5O3
4-Hydroxycilostazol
385.2114
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Adenosine monophosphate
H
Hydrogen Ion
1.007825
SMILES
O[C@H]1CC[C@H](CC1)N1N=NN=C1CCCCOC1=CC2=C(NC(=O)CC2)C=C1
6076
PubChem-compound
SMILES
OC1CC(O)=NC2=C1C=C(OCCCCC1=NN=NN1C1CCCCC1)C=C2
SMILES
OC1CCC(CC1)N1N=NN=C1CCCCOC1=CC=C2NC(=O)CCC2=C1
SMILES
O=C1NC2=CC=C(OCCCCC3=NN=NN3C3CCCCC3)C=C2C=C1
HMDB0059597
HMDB
1.0
HMDB0015297
HMDB
C00020
KEGG Compound
Cilostazol Action Pathway
60-92-4
CAS