206PathwayEptifibatide Action PathwayEptifibatide (also named Integrilin) is an anti-coagulant drug that is produced from Sistrurus miliarus barbouri, which can block platelet glycoprotein IIb/IIIa receptor to prevent platelet aggregation. Although, inhibition of platelet aggregation occurs in a dose- and concentration-dependent manner. Drug ActionPW000292TopPathwayVisualizationContext3081200800#000099PathwayVisualization212206Eptifibatide PathwayEptifibatide (also named Integrilin) is an anti-coagulant drug that is produced from Sistrurus miliarus barbouri, which can block platelet glycoprotein IIb/IIIa receptor to prevent platelet aggregation. Although, inhibition of platelet aggregation occurs in a dose- and concentration-dependent manner. Drug1557Eptifibatide inhibition of IntegrinInhibitorySubPathway923829ProteinComplex15924757ProteinComplex1489817054247Ciccone A, Abraha I, Santilli I: Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD005208. doi: 10.1002/14651858.CD005208.pub2.206Pathway89918520712Jennings LK, Saucedo JF: Antiplatelet and anticoagulant agents: key differences in mechanisms of action, clinical application, and therapeutic benefit in patients with non-ST-segment-elevation acute coronary syndromes. Curr Opin Cardiol. 2008 Jul;23(4):302-8. doi: 10.1097/HCO.0b013e3283021ad9.206Pathway1CellCL:00000001Homo sapiens9606EukaryoteHuman11Extracellular SpaceGO:000561510Cell MembraneGO:00058868Blood VesselBTO:0001102741115111PW_BS00001514101PW_BS00001441811PW_BS0000415181PW_BS0000515753EptifibatideDB0006313425151788Integrin alpha-IIbP08514Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surfaceHMDBP02103ITGA2B17q21.32AC003043110031413616641136174515696Integrin beta-3P05106L2883211004141361674113617551829Eptifibatide1PW_P0008299535753757Integrin1PW_P00075785317881854569612908575315159false3403458subunitregular15070290917881497false3406558noneregular1507029105696142false3406358proteinregular1507025768292121528972908257775721214289829092899291010359M415 415 C416 447 414 598 415 635 148false18falsetrueM 522 316 L 537 316 L 552 31610360M415 635 C415 605 415 445 415 415 148true1861655721214true8014516regular291257610359Left292257710360Right7907430251.01.00211580250478M115 781 C115 731 165 681 215 681 C327 681 471 681 583 681 C633 681 683 731 683 781 C683 845 683 929 683 993 C683 1043 633 1093 583 1093 C471 1093 327 1093 215 1093 C165 1093 115 1043 115 993 C115 929 115 845 115 781 1true6568.0412.036525016049281750115544701874