220PathwayAnistreplase Action PathwayAnistreplase, trade name Eminase, is a thrombolytic drug prescribed to treat acute myocardial infarction. The drug is an acylated streptokinase-plasminogen complex. The acylation of the drug renders it temporarily inactive, protecting it from plasmin inhibitors. Anistreplase is deacylated following injection, activating the drug to increase thrombolysis by increasing plasminogen's conversion to plasmin. Plasmin breaks down the fibrin of the thrombus to break up the clot and release arterial blockages. Anistreplase has been shown to be very effective when administered shortly after onset of chest pain. Compared to other thrombolytic drugs, Anistreplase has a longer plasma half-life. It also advantageous as it can be given as a single bolus intravenous injection. Drug ActionPW000303TopPathwayVisualizationContext3191000800#000099PathwayVisualization223220Anistreplase PathwayAnistreplase, trade name Eminase, is a thrombolytic drug prescribed to treat acute myocardial infarction. The drug is an acylated streptokinase-plasminogen complex. The acylation of the drug renders it temporarily inactive, protecting it from plasmin inhibitors. Anistreplase is deacylated following injection, activating the drug to increase thrombolysis by increasing plasminogen's conversion to plasmin. Plasmin breaks down the fibrin of the thrombus to break up the clot and release arterial blockages. Anistreplase has been shown to be very effective when administered shortly after onset of chest pain. Compared to other thrombolytic drugs, Anistreplase has a longer plasma half-life. It also advantageous as it can be given as a single bolus intravenous injection. Drug1560Anistreplase activation of PlasminogenActivatingSubPathway930833ProteinComplex15931157ProteinComplex1593218520712Jennings LK, Saucedo JF: Antiplatelet and anticoagulant agents: key differences in mechanisms of action, clinical application, and therapeutic benefit in patients with non-ST-segment-elevation acute coronary syndromes. Curr Opin Cardiol. 2008 Jul;23(4):302-8. doi: 10.1097/HCO.0b013e3283021ad9.220Pathway93312173205Walker CP, Royston D: Thrombin generation and its inhibition: a review of the scientific basis and mechanism of action of anticoagulant therapies. Br J Anaesth. 2002 Jun;88(6):848-63. doi: 10.1093/bja/88.6.848.220Pathway2797292198125Munger MA, Forrence EA: Anistreplase: a new thrombolytic for the treatment of acute myocardial infarction. Clin Pharm. 1990 Jul;9(7):530-40.220Pathway2797302193460Marinac JS, North DS, Stringer KA: Anistreplase: a novel thrombolytic agent for acute myocardial infarction. DICP. 1990 Jun;24(6):607-15.220Pathway1CellCL:00000001Homo sapiens9606EukaryoteHuman11Extracellular SpaceGO:00056151CytosolGO:00058298Blood VesselBTO:0001102741115111PW_BS0000155181PW_BS000051801111PW_BS0000802111PW_BS0000025756AnistreplaseDB000291344515141178511716PlasminogenP00747Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivoHMDBP01984PLG6q26M3427213.4.21.725021513948251139624801399842833Anistreplase1PW_P0008339585756157Plasminogen1PW_P00015717517162974575615159false3354108subunitregular1507029751716152false3357408subunitregular15070262183322315296329742622157223152964297510465M410 480 C410 509 410 699 410 740 149false18trueM 482.5 235.99038105676658 L 475 223 L 467.5 235.99038105676658false10466M410 810 C410 840 470 165 470 195 149true1863056022314true39519516regular319262110465Left320262210466Right8017435351.01.002115802503762471656428973893944674650CenterPathwayVisualizationContext78532004100#000099PathwayVisualization95339Coagulation Blood coagulation can be initiated by either an extrinsic or an intrinsic pathway, resulting in a cascade of serine protease activation that ultimately leads to the formation of thrombin, which converts soluble fibrinogen to an insoluble fibrin clot. The extrinsic, or tissue factor, pathway is initiated upon vascular injury, when the membrane-bound protein tissue factor (TF) comes into contact with factor VII or VIIa in plasma. The TF-VIIa complex is the strongest known activator of the coagulation cascade, and converts factors IX and X to IXa and Xa, respectively. Factors VII, IX, and X are vitamin-K-dependent proteins produced in the liver. In the intrinsic, or contact, pathway, injury exposes collagen to the bloodstream where is binds to factor XII and activates it to XIIa. Factor XIIa converts prekallikrein to kallikrein and factor XI to XIa. Both the extrinsic and intrinsic pathways result in the activation of factor IX to IXa, which forms the 'tenase' complex with factor VIIIa, calcium and phospholipids. This complex converts factor X to Xa and is important in haemostasis. Factor Xa complexes with factor Va (which functions as a non-enzymatic cofactor), calcium and a phospholipid membrane surface to form what is called the prothrombinase complex, which converts prothrombin to thrombin. Thrombin converts soluble fibrinogen to insoluble fibrin polymer, which is stabilized by cross-linking by coagulation factor XIIIa.Protein1184XII activated to XIIa by CollagenActivatingSubPathway285130ProteinComplex15286196ProteinComplex15287151ProteinComplex15186XII activated to XIIa by Plasma kallikreinActivatingSubPathway289130ProteinComplex15290134ProteinComplex15291151ProteinComplex15188Plasma prekallikrein activated to Plasma kallikrein by XIIaActivatingSubPathway293602ProteinComplex15294151ProteinComplex15295134ProteinComplex216Coagulation factor XIII A and B activate to Coagulation factor XIIIaActivatingSubPathway333144ProteinComplex334145ProteinComplex335638ProteinComplex235Activate Coagulatin factor VII to VIIa by binding to Tissue FactorActivatingSubPathway354127ProteinComplex355198ProteinComplex356643ProteinComplex188319372258van der Meijden PE, Munnix IC, Auger JM, Govers-Riemslag JW, Cosemans JM, Kuijpers MJ, Spronk HM, Watson SP, Renne T, Heemskerk JW: Dual role of collagen in factor XII-dependent thrombus formation. Blood. 2009 Jul 23;114(4):881-90. doi: 10.1182/blood-2008-07-171066. Epub 2009 Apr 16.339Pathway188412787532Norris LA: Blood coagulation. Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.339Pathway2Platelet CL:00002331CellCL:00000004CardiomyocyteCL:00007463NeuronCL:00005408Beta cellCL:00006396MyocyteCL:00001875HepatocyteCL:00001821Homo sapiens9606EukaryoteHuman12Mus musculus10090EukaryoteMouse5Bos taurus9913EukaryoteCattle17Rattus norvegicus10116EukaryoteRat3Escherichia coli562Prokaryote6Caenorhabditis elegans6239EukaryoteRoundworm18Saccharomyces cerevisiae4932EukaryoteYeast4Arabidopsis thaliana3702EukaryoteThale cress10Drosophila melanogaster7227EukaryoteFruit fly2MitochondrionGO:000573911Extracellular SpaceGO:00056155CytoplasmGO:000573710Cell MembraneGO:00058861CytosolGO:000582919Sarcoplasmic ReticulumGO:00165297Endoplasmic Reticulum MembraneGO:000578924Mitochondrial Intermembrane SpaceGO:000575825Golgi ApparatusGO:000579414Mitochondrial Outer MembraneGO:000574112Mitochondrial Inner MembraneGO:000574313Endoplasmic ReticulumGO:00057836LysosomeGO:000576416Lysosomal LumenGO:004320236MembraneGO:00160202Endothelium BTO:00003935cardiocyteBTO:00015391LiverBTO:000075972918PancreasBTO:00009888Blood VesselBTO:000110274116KidneyBTO:00006717189MuscleBTO:00008871411816212PW_BS0000163211PW_BS00000315111PW_BS0000151122121PW_BS000112407251PW_BS0001151192171PW_BS0001198511PW_BS00000814101PW_BS0000142111PW_BS000002215114PW_BS0000213551914PW_BS00003546114PW_BS000046471914PW_BS00004749711PW_BS000049422411PW_BS000042432511PW_BS0000435811411PW_BS000058171211PW_BS000017181311PW_BS0000189611PW_BS000009711113PW_BS00007172513PW_BS00007229111PW_BS0000296618518PW_BS000066101711PW_BS0000102811611PW_BS0000281115121PW_BS000111101531PW_BS000101205561PW_BS0000242111018PW_BS0000241601181PW_BS0001601901118PW_BS0000242137181PW_BS0000241985181PW_BS00002421013181PW_BS0000241644PW_BS0001642851041PW_BS000024151141PW_BS0001513081011PW_BS00002411PW_BS0000013317121PW_BS0000281151012PW_BS0001151321121PW_BS00013235625121PW_BS00002834524121PW_BS00002813013121PW_BS0001301141112PW_BS0001147413PW_BS000074228361PW_BS0000245181PW_BS000051122551PW_BS000122405105PW_BS000115124151PW_BS0001244182451PW_BS0001154192551PW_BS000115383751PW_BS0001001251351PW_BS000125409115PW_BS0001151355171PW_BS0001353761017PW_BS0000531181171PW_BS00011845424171PW_BS00011545525171PW_BS0001153987171PW_BS00011313613171PW_BS0001361371117PW_BS0001372975101PW_BS0000244781010PW_BS00011548924101PW_BS0001152991101PW_BS00002449025101PW_BS0001154957101PW_BS000115209106PW_BS0000245062461PW_BS000115388161PW_BS0001125072561PW_BS000115390761PW_BS0001127906111PW_BS0005248346111PW_BS000549509516PW_BS000050261115PW_BS000026311511PW_BS0000313361121PW_BS000028429151PW_BS0001154641171PW_BS00011541811PW_BS000041801111PW_BS0000808681111PW_BS0000869CortexoloneHMDB0000015Cortexolone is the precursor of cortisol. Accumulation of cortexolone can happen in a defect known as congenital adrenal hyperplasia, which is due to 11-beta-hydroxylase deficiency, resulting in androgen excess, virilization, and hypertension (PMID: 2022736). Cortexolone is a 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities (PubChem).152-58-9C054884407072832411-DEOXY-CORTISOL389582[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12CC21H30O4InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1WHBHBVVOGNECLV-OBQKJFGGSA-N(1S,2R,10R,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one346.4605346.214409448-4.142(1S,2R,10R,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one00FDB02187211-deoxy-17-hydroxy-corticosterone;11-deoxy-17-hydroxycorticosterone;11-deoxy-cortisol;11-deoxycortisol;11-deoxyhydrocortisone;11-desoxy-17-hydroxycorticosterone;11-desoxycortisol;11-desoxyhydrocortisone;11-dioxy-cortisol;11-dioxycortisol;17,21-dihydroxy-4-pregnene-3,20-dione;17,21-dihydroxypregn-4-ene-3,20-dione;17,21-dihydroxyprogesterone;17-hydroxy-11-deoxycorticosterone;17alpha-hydroxycortexone;20-dione 17,21-dihydroxypregn-4-ene-3;4-pregnene-17alpha,21-diol-3,20-dione;Cortodoxone;Reichstein s;Reichstein's compound s;Reichstein's substance sPW_C000009Cortexo1123162311323191578981112121823407124376119353CalciumHMDB0000464Calcium is essential for the normal growth and maintenance of bones and teeth, and calcium requirements must be met throughout life. Requirements are greatest during periods of growth, such as childhood, during pregnancy and when breast-feeding. Long-term calcium deficiency can lead to osteoporosis, in which the bone deteriorates and there is an increased risk of fractures. Adults need between 1,000 and 1,300 mg of calcium in their daily diet. Calcium is essential for living organisms, particularly in cell physiology, and is the most common metal in many animals. Physiologically, it exists as an ion in the body. Calcium combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Calcium is an important component of a healthy diet. A deficit can affect bone and tooth formation, while overretention can cause kidney stones. Vitamin D is needed to absorb calcium. Dairy products, such as milk and cheese, are a well-known source of calcium. However, some individuals are allergic to dairy products and even more people, particularly those of non-European descent, are lactose-intolerant, leaving them unable to consume dairy products. Fortunately, many other good sources of calcium exist. These include: seaweeds such as kelp, wakame and hijiki; nuts and seeds (like almonds and sesame); beans; amaranth; collard greens; okra; rutabaga; broccoli; kale; and fortified products such as orange juice and soy milk. Calcium has also been found to assist in the production of lymphatic fluids.14127-61-8C0007627129108CA%2b2266DB01373[Ca++]CaInChI=1S/Ca/q+2BHPQYMZQTOCNFJ-UHFFFAOYSA-Ncalcium(2+) ion40.07839.9625911550calcium(2+) ion22FDB003513Ca;Calcium element;Ca(2+);Ca2+;Calcium ion;Calcium, doubly charged positive ionPW_C000353Ca2+276163038553146012941159932199735104631163461164471478491491421552432116582138172796182937931597131607239422941866647821048222853401115780101717920572322117258160728119011774213118371981184221012198164122152851528815115350308693361773893317760011578154132782663567852634578724130789081148041374805892288182651120220122120465405121049124121300418121377419121850383121923125122370409122895135123099376123613118123870454123936455124403398124476136124924137125571297125711478125981489126009299126050490126533495127203209127434506127460388127502507128105390140676790140677834140695501746Vitamin K1 2,3-epoxideHMDB0002972Vitamin K1 2,3-epoxide is a vitamin K derivative. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation. Within the cell, vitamin K undergoes electron reduction to a reduced form of vitamin K (called vitamin K hydroquinone) by the enzyme vitamin K epoxide reductase (or VKOR). Another enzyme then oxidizes vitamin K hydroquinone to allow carboxylation of glutamate into gamma-carboxyglutamate (Gla). This enzyme is called the gamma-glutamyl carboxylase or the vitamin K-dependent carboxylase. The carboxylation reaction will only proceed if the carboxylase enzyme is able to oxidize vitamin K hydroquinone into vitamin K epoxide at the same time; the carboxylation and epoxidation reactions are said to be coupled reactions. Vitamin K epoxide is then re-converted into vitamin K by the vitamin K epoxide reductase. These two enzymes comprise the so-called vitamin K cycle. One of the reasons why vitamin K is rarely deficient in a human diet is because vitamin K is continually recycled in our cells. Vitamin K 2,3-epoxide is the substrate for vitamin K 2,3-epoxide reductase (VKOR) complex. Significantly increased level of serum vitamin K epoxide has been found in patients with familial multiple coagulation factor deficiency (PMID: 12384421). Accumulation of vitamin K1-2,3-epoxide in plasma is also a sensitive marker of coumarin-like activity of drugs (PMID: 2401753).
25486-55-9C05849915772837123-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ82688CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\C[C@@]12O[C@]1(C)C(=O)C1=C(C=CC=C1)C2=OC31H46O3InChI=1S/C31H46O3/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-31-29(33)27-19-8-7-18-26(27)28(32)30(31,6)34-31/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-,30-,31+/m1/s1KUTXFBIHPWIDJQ-BTPXSFBUSA-N(1aS,7aR)-1a-methyl-7a-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1aH,2H,7H,7aH-naphtho[2,3-b]oxirene-2,7-dione466.706466.344695341-7.320(1aS,7aR)-1a-methyl-7a-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphtho[2,3-b]oxirene-2,7-dione00FDB023087(2,3-epoxyphytyl)menaquinone;1,4-naphthoquinone, 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-2,3-epoxyphylloquinone;2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone;2,3-epoxyphylloquinone;Naphth[2,3-b]oxirene-2,7-dione, 1a,7a-dihydro-1a-methyl-7a-(3,7,11,15-tetramethyl-2-hexadecenyl)-phylloquinone oxide;Phylloquinone 2,3-epoxide;Phylloquinone-2,3-epoxide;Vitamin k 2,3-epoxide;Vitamin k epoxide;Vitamin k1 oxide;1a,7a-dihydro-1a-methyl-7a-(3,7,11,15-tetramethyl-2-hexadecenyl)-naphth[2,3-b]oxirene-2,7-dione;Phylloquinone epoxide;Phylloquinone oxide;Phylloquinone, epoxide;Vitamin k1 2,3-epoxide;Vitamin k1, epoxidePW_C001746VitKo49526147231166129456018792243361212814291238524642089Reduced Vitamin K (phylloquinone)HMDB0004198Vitamin K is a family of fat-soluble compounds with a common chemical structure based on 2-methyl-1,4-naphthoquinone.
Phylloquinone is often called vitamin K1, phytomenadione or phytonadione. Sometimes a distinction is made with phylloquinone considered natural and phytonadione considered synthetic. A stereoisomer of phylloquinone is called vitamin k1 (note the difference in capitalization). (Wikipedia). Phylloquinone is present in food of plant origin, such as green, leafy vegetables and certain plant oils, and is the predominant form in the diet. Bacterial and other forms of vitamin K, referred to as the menaquinones, differ in structure from phylloquinone in their 3-substituted lipophilic side chain. Menaquinone-4 (MK-4), which is alkylated from menadione, is present in animal feeds or is the product of tissue-specific conversion directly from dietary phylloquinone. Vitamin K is a cofactor specific to the formation of gamma-carboxyglutamyl (Gla) residues in certain proteins, including prothrombin necessary for normal hemostatic function. The naturally occurring forms of vitamin K are quinones (i.e. phylloquinone and menaquinones) so vitamin K is reduced to the vitamin K hydroquinone prior to catalyzing the gamma-carboxylation reaction. The active site for the carboxylation reaction is on the napthoquinone ring, which is identical for all forms of vitamin K, including phylloquinone and MK-4. (PMID 16857056).84-80-0C058505284607180674447652DB01022CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(O)C2=C(C=CC=C2)C(O)=C1CC31H48O2InChI=1S/C31H48O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24,32-33H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1BUFJIHPUGZHTHL-NKFFZRIASA-N2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-diol452.7116452.36543078-6.982vitamin K hydroquinone00FDB023333Vitamin k hydroquinone (phylloquinone);2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione;2-methyl-3-[(2e)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone;2-methyl-3-phytyl-1,4-naphthochinon;2-methyl-3-phytyl-1,4-naphthoquinone;3-phytylmenadione;Alpha-phylloquinone;Fitomenadiona;Phyllochinon;Phyllochinonum;Phytomenadione;Phytomenadionum;Phytonadione;Phytonadionum;Phytylmenadione;Trans-phylloquinone;Vitamin k1PW_C002089ReVitK496261471311610297922133612127642912384746445Prothrombin and coagulation factors VII, IX and XProteinComplexPW_EC000045P00734UniProtPACFVIA44Precursors of Prothrombin and coagulation factors VII, IX, ad XProteinComplexPW_EC000044P00734UniProtPOPACFV1758Coagulation factor XIIaP00748Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIaHMDBP02054F125q33-qterM1172313.4.21.381122162315151365334113947251139575801583Collagen alpha-1(I) chainP02452Type I collagen is a member of group I collagen (fibrillar forming collagen)HMDBP01757COL1A117q21.33M10627197215112616139577801775Plasma kallikreinP03952The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into reninHMDBP02080KLKB14q35CH47105613.4.21.3411251623181513947351139574805691Coagulation factor XIaP03951CH47105613.4.21.271131161365324113947451139576801571Coagulation factor IXP00740Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIaHMDBP01730F9S6675213.4.21.221141162472151365344113653851139578801570Coagulation factor VIIIP00451Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor XaHMDBP01727F8M8863312463151365364113653751139579805692ThrombinP00734BC05133213.4.21.59591424641545641845682826748013654151141428861795Coagulation factor VP12259Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombinHMDBP02118F51q23DQ377944113654051139583801730Coagulation factor XP00742Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clottingHMDBP02011F1013q34L0039513.4.21.62471151365354113653951139582801397722141427865693Fibrinogen alpha chainP02671J001271247615136168411365425113958480141429865694Fibrinogen beta chainP02675J001291247715136169411365435113958580141430861699Fibrinogen gamma chainP02679Fibrinogen has a double function:yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregationHMDBP01954FGG4q28CH471056124781513617041136544511395868014143186636Coagulation factor XIII A chainP00488Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
HMDBP00672F13A16p25.3-p24.3M2199612.3.2.1324871513654551139591805695Coagulation factor XIII B chainP05160M64554124881513654651139592801716PlasminogenP00747Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivoHMDBP01984PLG6q26M3427213.4.21.7250215139482511396248013998421655Tissue-type plasminogen activatorP00750Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migrationHMDBP01868PLAT8p12BC00279513.4.21.6825031513948351139625801732Coagulation factor VIIaP08709Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calciumHMDBP02013F713q34DQ14291113.4.21.214972630702913948051139581805701Tissue factorP13726AF487337113948151139580801852Vitamin K epoxide reductase complex subunit 1Q9BQB6Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.
HMDBP02242VKORC116p11.2AK28979011.17.4.451126166229307210456218141340151545Vitamin K-dependent gamma-carboxylaseP38435Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
HMDBP01691GGCX2p12AK29739714.1.1.9049826147331166329252915456618848710130Coagulation factor XII1PW_P0001301481758196Collagen alpha-1(I) chain1PW_P0001962141583151Coagulation factor XIIa1PW_P00015116917586591134Plasma kallikrein1PW_P0001341521775132Coagulation factor XI1PW_P0001321505691136Coagulation factor XIa1PW_P0001361545691613531131Coagulation factor IX1PW_P0001311491571137Coagulation factor IXa1PW_P0001371551571623531199Coagulation factor VIII1PW_P0001992171570625Coagulation factor VIIIa1PW_P0006256701570140Thrombin1PW_P0001401585692633531200Coagulation factor V1PW_P0002002181795630Coagulation factor Va1PW_P0006306761795133Coagulation factor X1PW_P00013315117302923531624Coagulation factor Xa1PW_P0006246691730627Tenase complex1PW_P000627672157067315712913531245615138Prothrombin1PW_P0001381565692634Fibrinogen1PW_P000634681569368256946831699635Fibrin (loose)1PW_P000635684569368556946861699637Fibrin (mesh)1PW_P000637689569369056946911699144Coagulation factor XIII A chain1PW_P000144162636643531145Coagulation factor XIII B chain1PW_P0001451635695638Coagulation factor XIIIa1PW_P00063869263669356952953531641Fibrin degradation products1PW_P000641696569369756946981699642Plasmin1PW_P0006426991716157Plasminogen1PW_P0001571751716156Tissue-type plasminogen activator1PW_P0001561741655127Coagulation factor VII1PW_P0001271451732198Tissue factor1PW_P0001982165701643Tissue factor:Coagulation factor VIIa1PW_P000643700173270157012963531250415146Vitamin K epoxide reductase complex subunit 11PW_P0001461641852129Vitamin K-dependent gamma-carboxylase1PW_P0001291471545602Plasma prekallikrein1PW_P00060264617751632Prothrombinase Complex1PW_P000632678179567917302933531247515662falsePW_R000662Right27211321ProteinComplexfalse27221361ProteinComplexfalse1551513.4.21.38832falsePW_R000832Right33721311ProteinComplexfalse33731371ProteinComplexfalse3811363.4.21.271383falsePW_R001383Right52571991ProteinComplexfalse52586251ProteinComplexfalse11031403.4.21.51386falsePW_R001386Right52652001ProteinComplexfalse52666301ProteinComplexfalse11051403.4.21.51380falsePW_R001380Right52491331ProteinComplexfalse52506241ProteinComplexfalse11006273.4.21.2211266433.4.21.211389falsePW_R001389Right52711381ProteinComplexfalse52721401ProteinComplexfalse11086323.4.21.61391falsePW_R001391Right52756341ProteinComplexfalse52766351ProteinComplexfalse11101403.4.21.51397falsePW_R001397Right52886351ProteinComplexfalse52896371ProteinComplexfalse11156382.3.2.131405falsePW_R001405Right53146371ProteinComplexfalse53156411ProteinComplexfalse11246423.4.21.71406falsePW_R001406Right53161571ProteinComplexfalse53176421ProteinComplexfalse11251563.4.21.68652falsePW_R000652Right269017461Compoundfalse269120891Compoundfalse1421461.1.4.11409falsePW_R001409Right532620891Compoundfalse532717461Compoundfalse11291294.1.1.901414falsePW_R001414Right5344441ElementCollectionfalse5345451ElementCollectionfalse11341294.1.1.9080PW_T00008090451ElementCollection2951Right430899false170094010regular1002543229159true169594010regular1002544093539false1985134510regular10025441099false1705123510regular1002547393539false2245149010regular1002547403539true735119010regular100254759353159false2670133510regular1002547653539false3040158510regular100254768353159false2600162510regular100254769353159true855147010regular100254771353159false2945181010regular100254773353159true1650164510regular1002548253539false2735221010regular100254826353159false3180233010regular1002548273539false3230129510regular1002548283539true1540104010regular1002548293539true1755105010regular10025484117463false500101010regular100110484220893false1085100010regular100120484620893true10015010regular100120484717463true10015010regular10011089479159false157076010regular10025115453729true485149512regular10090116453751true735149512regular10090275443715false935140512regular10090276453715false575140512regular1009016191758152false16759508subunitregular1507016201583152false22606558subunitregular15070162117582false168011858proteinregular1507016271758152true7907158subunitregular1507016281775152false14609508subunitregular1507016291758152true11308158proteinregular15070166956912false143512858subunitregular15070167056912false196012958proteinregular15070167117582true6509908subunitregular15070180115712false170514258subunitregular15070180215712false225514358proteinregular15070180356912true73511958subunitregular1507018161570152false239011108proteinregular1507018171570152false232014758proteinregular1507018185692152false258012858subunitregular15070182017952false330015358subunitregular15070182117952false266516108proteinregular15070182256922false301515358subunitregular1507018271730152false198515858subunitregular1507018281730152false258515708proteinregular1507018291570152true86014008subunitregular1507018301571152true85514708subunitregular1507018355692152false229017608subunitregular1507018365692152false292017608proteinregular1507018395693152false263518608subunitregular1507018405694152false263519108subunitregular1507018411699152false263519558subunitregular15070184256931516false317019008proteinregular1709018435694152true187516458subunitregular1507018441699152true187516708subunitregular1507018455692152true165016458subunitregular150701852569315136false307527308proteinregular17515518535694152true211019608subunitregular1507018541699152true197019658subunitregular1507018766362false271022208subunitregular15070187756952false271023358subunitregular1507018786366true4302408proteinregular16080187956952true4202308subunitregular15070188056932true193521708subunitregular15070188156942true193522008subunitregular15070188216992true193522358subunitregular15070188356932false368027758proteinregular15070188456942true234523008subunitregular15070188516992true226022358subunitregular15070188617162false333027758proteinregular1507018871716152false333024408subunitregular1507018881716152true212520958subunitregular1507018891655152false333026158subunitregular150701890636152false309022808proteinregular1507018915695152true1252258subunitregular15070189217322false332010608subunitregular15070189357012false24656558subunitregular15070189417322false320512458proteinregular15070189557012true2051858subunitregular15070189617302false356013958subunitregular15070189717302true183513258subunitregular15070189817322true162011158proteinregular15070189957012true3602658subunitregular1507019051852102false7758808subunitregular1507019071545102false73512308subunitregular1507048881775152false13707708proteinregular1507048891758152false15457708proteinregular15070149613095151612161914971969515161316201498151951614162175643086389Cofactor15041309515162016271505134951516211628150615195151622162975843226419Cofactor154613295166216691547136951663167077944096571Cofactor1548151951664167178044106573Cofactor167613195179418011677137951795180282747397075Cofactor1678136951796180382847407077Cofactor16901999515180918161691625951518101817169214095151811181883547597110Cofactor16942009518131820169563095181418211696140951815182283647657119Cofactor169913395151820182783747687124Cofactor170062495151821182817016279515182218291823183083847697127Cofactor1705138951518281835170614095151829183683947717135Cofactor1709634951518321839183318401834184117106359515183518421836184318371844171114095151838184584047737147Cofactor171763795151845185218461853184718541737144951869187685348257236Cofactor1738145951870187717396389518711878187218791740637951873188018741881187518821741641951876188318771884187818851742642951879188617431579515188018871744642951518811888174515695151882188917466389515188318901884189185448267244Cofactor1747127951885189217481989518861893174964395188718941888189585548277247Cofactor1750133951889189685648287249Cofactor17516249518901897175264395189118981892189985748297252Cofactor1758146951898190517601299519001907405160295154861488840521519515486248891730894713970Cofactor6387M1825 985 C1857 996 1851 1149 1809 1195 149false18trueM 297.0096189432334 257.5 L 310 250 L 297.0096189432334 242.5false6388M2260 690 C2096 718 1864 1033 1839 1125 149false18falsefalse6389M700 235 L700 285 L750 235 z10true186390M1680 1220 C1650 1220 1855 985 1825 985 5true186417M1675 985 C1656 1007 1655 1141 1703 1199 149false18trueM 392.41909384706423 811.9433327199906 L 400 799 L 385.00029197838586 798.9064090478472false6418M1610 985 C1686 1036 1639 1048 1672 1130 149false18falsefalsefalsefalse6419M700 235 L700 285 L750 235 z10true186420M1130 850 C1100 850 970 750 940 750 5true186570M1510 1285 C1546 1230 1650 1220 1680 1220 5false186571M700 300 L700 350 L750 300 z10true186572M2035 1295 C2003 1233 1860 1220 1830 1220 5false18trueM 717.5299975319052 868.3366083298732 L 730 860 L 716.5452841708815 853.3689652423119false6573M475 325 L475 375 L525 325 z10true187074M1780 1425 C1810 1362 1930 1330 1960 1330 5false187075M700 300 L700 350 L750 300 z10true187076M2330 1435 C2292 1364 2140 1330 2110 1330 5false18trueM 987.2576570145123 1033.0859179155007 L 1000 1041 L 1000.4826246400679 1026.0077662285835false7077M475 325 L475 375 L525 325 z10true187108M2540 1145 C2606 1151 2663 1257 2655 1285 5false187109M2470 1510 C2500 1510 2645 1493 2655 1355 5false18trueM 1142.9903810567666 1112.5 L 1130 1120 L 1142.9903810567666 1127.5false7110M250 300 L250 350 L300 300 z10true187117M3300 1570 C3270 1570 3195 1570 3165 1570 5false187118M2815 1645 C2845 1645 2985 1570 3015 1570 5false18trueM 1442.9903810567666 1287.5 L 1430 1295 L 1442.9903810567666 1302.5false7119M250 300 L250 350 L300 300 z10true187124M250 300 L250 350 L300 300 z10true187125M2060 1585 C2106 1503 2225 1470 2255 1470 5false187126M2660 1570 C2609 1486 2435 1470 2405 1470 5false18trueM 1187.0096189432334 1257.5 L 1200 1250 L 1187.0096189432334 1242.5false7127M475 355 L475 405 L525 355 z10true187134M2365 1760 C2373 1656 2520 1604 2585 1605 5false187135M250 300 L250 350 L300 300 z10true187136M2995 1760 C2982 1645 2798 1605 2735 1605 5false18trueM 1595.8550173541616 1468.11011806588 L 1605 1480 L 1610.7244484800265 1466.135271744476false7145M2710 1860 C2756 1802 2890 1795 2920 1795 5false187146M3255 1900 C3243 1839 3100 1795 3070 1795 5false18trueM 1762.0096189432334 1562.5 L 1775 1555 L 1762.0096189432334 1547.5false7147M475 340 L475 390 L525 340 z10true187167M3255 1990 C3255 2020 3165 2250 3165 2280 5false187168M3165 2737 C3165 2707 3165 2380 3165 2350 5false18trueM 1947.5 1819.0096189432334 L 1955 1832 L 1962.5 1819.0096189432334falsefalsefalse7236M250 300 L250 350 L300 300 z10true187237M3090 2315 C3001 2311 2916 2320 2860 2255 149false18trueM 2110.9468550441647 1623.261556296296 L 2096 1622 L 2102.380887721186 1635.5751343230784false7238M3090 2315 C3008 2310 2913 2307 2860 2370 149false187239M2180 1807 C2203 1823 2243 1850 2267 1867 149true187240M3250 2810 C3280 2810 3300 2810 3330 2810 5false187241M3680 2810 C3650 2810 3510 2810 3480 2810 5false18trueM 2147.0096189432334 2127.5 L 2160 2120 L 2147.0096189432334 2112.5false7242M3405 2510 C3405 2538 3405 2570 3405 2615 5false187243M3405 2775 C3405 2749 3406 2711 3405 2685 5false18trueM 2106.5 2027.9903810567666 L 2099 2015 L 2091.5 2027.9903810567666false7244M250 300 L250 350 L300 300 z10true187245M3280 1245 C3291 1043 2521 852 2540 725 149false187246M3280 1245 C3275 1114 3386 1179 3395 1130 149false18trueM 1954.9468550441647 896.261556296296 L 1940 895 L 1946.380887721186 908.5751343230784false7247M250 300 L250 350 L300 300 z10true187248M111 162 C134 178 174 205 198 222 149true187249M250 300 L250 350 L300 300 z10true187250M3205 1280 C2901 1276 2671 1506 2660 1570 5false18trueM 1503.9903810567666 1144.5 L 1491 1152 L 1503.9903810567666 1159.5false7251M3635 1395 C3637 1350 3419 1281 3355 1280 5false18falsefalse7252M250 300 L250 350 L300 300 z10true187267M550 1010 C553 966 599 921 775 915 5false187268M1135 1000 C1123 947 1043 912 925 915 5false18trueM 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345false7273M810 1230 C923 1235 1123 1198 1135 1120 5false187274M550 1120 C552 1169 665 1229 810 1230 5false18trueM 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345false7360M625 1535 C630 1861 935 1807 1110 1809 C1378 1809 1784 1835 1780 1495 83false18trueM 1687.5 1357.9903810567666 L 1680 1345 L 1672.5 1357.9903810567666false7361M1109 1809 C1464 1801 2061 1847 2060 1655 83false18trueM 1225.0644009829866 1558.611518094107 L 1240 1560 L 1233.7346610946918 1546.371150877582false7372M1319 1808 C1356 1811 2361 2028 2365 1830 83false18trueM 1743.0644009829866 1770.611518094107 L 1758 1772 L 1751.7346610946918 1758.371150877582false7377M1681 1803 C1834 1833 1939 1949 2057 2012 C2247 2105 3486 2159 3776 2039 C3938 1994 3943 1275 3828 1157 C3721 1073 3648 1105 3470 1095 83false18trueM 3386.24113183082 862.9521331000902 L 3373 870 L 3385.7241976932232 877.943223090394false13969M1620 840 C1620 867 1536 924 1535 950 149false18trueM 1428.004802091561 786.730968150548 L 1435 800 L 1442.9937197110307 787.3074649820661false13970M250 300 L250 350 L300 300 z10true1813971M1445 840 C1445 866 1535 924 1535 950 149false18trueM 1427.5 787.0096189432334 L 1435 800 L 1442.5 787.0096189432334false13972M111 162 C134 178 174 205 198 222 5true1818068M985 1405 C985 1344 878 1299 810 1300 5false1818069M625 1405 C624 1352 741 1300 810 1300 5false18trueM 417.2562767252032 1242.1534148567266 L 425 1255 L 432.253607448556 1241.8704463525125false140995662615466570Left715476572Right13421551548151495832151216767074Left1316777076Right145238116781525951383151616907108Left1716917109Right1462110316921528951386151816947117Left1916957118Right1464110516961529951380152016997125Left2117007126Right1465110017011532951389152217057134Left2317067136Right1535951391152417097145Left2517107146Right1470111017111541951397152617107167Left2717177168Right1493111517461557951405152817407240Left2917417241Right1491112417421558951406153017437242Left3117447243Right14921125174515599513803217507250Left3317517251Right149411261752156195652543648417267Left543748427268Right149614217581563951409544248467273Left544348477274Right14981129176033029514141528427518068Left28527618069Right347211341760136809551157360Left61167361Right2301849514true34016516regular2314966387Left2414976388Left2514986390Right2331869514true32523016regular2615046417Left2715056418Left2815066420Right2702169514true10015016regular3517377237Left3617387238Left3717397239Right2712359514true10015016regular3817477245Left3917487246Left4017497248Right8441889514true10015016regular504405113969Left505405213971Left506150513972Right2737237377207742245951.31.302115802502087524704201.91.9021217713920975279026851.91.90212177139234723752253.43.40292001452377520654151.91.90212177139614666258501.31.302328036047986219011201.31.302143272674798631859300.60.6-2021490240611M128 874 C128 824 178 774 228 774 C515 774 888 774 1175 774 C1225 774 1275 824 1275 874 C1275 1063 1275 1308 1275 1497 C1275 1547 1225 1597 1175 1597 C888 1597 515 1597 228 1597 C178 1597 128 1547 128 1497 C128 1308 128 1063 128 874 1true61147.0823.0285235Platelet Factor 322301495201.01.020015286235Tenase complex22501550201.01.020015287235Platelet factor 325701630201.01.020015288235Prothrombinase complex25751700201.01.020015297235Endothelial Cell2080460201.31.320015298235Subendothelium2305405201.31.320015299235Vascular Injury2305575201.31.320015300235Endothelial Cell27952730201.31.320015301235SUBENDOTHELIUM29402940201.31.320015302235COAGULATION30202835201.31.320015892487229133941640003102442661268610250057510274813011625441199877