Toggle navigation
SMPDB
Browse SMPDB
Pathways
Table of Primary Pathways
Compounds
Proteins
Search
TextQuery Search Instructions
SMP-MAP Advanced Search
ChemQuery Structure Search
Molecular Weight Search
Sequence Search
About
About SMPDB
Release Notes
Citing SMPDB
Statistics
Other Databases
Pathway Legend
Pathway Category Definitions
PathWhiz
Downloads
Contact Us
Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loading Pathway...
Error: Pathway image not found.
Adenylate
cyclase type 2
Guanine
nucleotide-
binding protein
G(I)/G(S)/G(O)
subunit
gamma-12
Guanine
nucleotide-
binding protein
G(s) subunit
alpha isoforms
short
Gβ
Bcl2-associated
agonist of cell
death
Adenosine
receptor A2a
Nuclear factor
NF-kappa-B p105
subunit
Nuclear factor
NF-kappa-B p105
subunit
Nuclear factor
NF-kappa-B p100
subunit
Nuclear factor
NF-kappa-B p100
subunit
Adenosine
receptor A2a
Adenosine
receptor A2a
Guanine
nucleotide-
binding protein
G(I)/G(S)/G(O)
subunit
gamma-12
Gβ
Guanine
nucleotide-
binding protein
G(s) subunit
alpha isoforms
short
Guanine
nucleotide-
binding protein
G(s) subunit
alpha isoforms
short
Guanine
nucleotide-
binding protein
G(I)/G(S)/G(O)
subunit
gamma-12
Gβ
Adenylate
cyclase type 2
Guanine
nucleotide-
binding protein
G(s) subunit
alpha isoforms
short
cAMP-dependent
protein kinase
catalytic
subunit beta
cAMP-dependent
protein kinase
catalytic
subunit beta
Cyclic
AMP-responsive
element-binding
protein 1
Cyclic
AMP-responsive
element-binding
protein 1
Rap guanine
nucleotide
exchange factor
3
Ras-related
protein Rap-1A
Ras-related
protein Rap-1A
Rap guanine
nucleotide
exchange factor
3
Dual
specificity
mitogen-
activated
protein kinase
kinase 2
Dual
specificity
mitogen-
activated
protein kinase
kinase 2
Ras-related
protein Rap-1A
Serine/threonine-
protein kinase
B-raf
Serine/threonine-
protein kinase
B-raf
Dual
specificity
mitogen-
activated
protein kinase
kinase 2
Dual
specificity
mitogen-
activated
protein kinase
kinase 2
Mitogen-
activated
protein kinase
1
Mitogen-
activated
protein kinase
1
ETS domain-
containing
protein Elk-1
ETS domain-
containing
protein Elk-1
Rap guanine
nucleotide
exchange factor
2
Rap guanine
nucleotide
exchange factor
2
GTPase HRas
GTPase HRas
Phosphatidylinositol-
4,5-
bisphosphate
3-kinase
catalytic
subunit alpha
isoform
GTPase HRas
Phosphatidylinositol-
4,5-
bisphosphate
3-kinase
catalytic
subunit alpha
isoform
Rho guanine
nucleotide
exchange factor
7
Rho guanine
nucleotide
exchange factor
7
Cell division
control protein
42 homolog
Cell division
control protein
42 homolog
Mitogen-
activated
protein kinase
kinase kinase 4
Mitogen-
activated
protein kinase
kinase kinase 4
Cell division
control protein
42 homolog
Mitogen-
activated
protein kinase
kinase kinase 1
Mitogen-
activated
protein kinase
kinase kinase 1
Dual
specificity
mitogen-
activated
protein kinase
kinase 7
Dual
specificity
mitogen-
activated
protein kinase
kinase 7
Mitogen-
activated
protein kinase
8
Mitogen-
activated
protein kinase
8
Transcription
factor AP-1
Transcription
factor AP-1
Cell division
control protein
42 homolog
Serine/threonine-
protein kinase
PAK 1
Serine/threonine-
protein kinase
PAK 1
Dual
specificity
mitogen-
activated
protein kinase
kinase 6
Dual
specificity
mitogen-
activated
protein kinase
kinase 6
Mitogen-
activated
protein kinase
11
Mitogen-
activated
protein kinase
11
Cyclic
AMP-dependent
transcription
factor ATF-2
Cyclic
AMP-dependent
transcription
factor ATF-2
Partitioning
defective 6
homolog alpha
Protein kinase
C zeta type
Cell division
control protein
42 homolog
Partitioning
defective 6
homolog alpha
Protein kinase
C zeta type
Ribosomal
protein S6
kinase alpha-1
Ribosomal
protein S6
kinase alpha-1
Bcl2-associated
agonist of cell
death
3-
phosphoinositide-
dependent
protein kinase
1
3-
phosphoinositide-
dependent
protein kinase
1
RAC-alpha
serine/threonine-
protein kinase
RAC-alpha
serine/threonine-
protein kinase
RAC-alpha
serine/threonine-
protein kinase
Inhibitor of
nuclear factor
kappa-B kinase
subunit alpha
Inhibitor of
nuclear factor
kappa-B kinase
subunit beta
Inhibitor of
nuclear factor
kappa-B kinase
subunit alpha
Inhibitor of
nuclear factor
kappa-B kinase
subunit beta
NF-kappa-B
inhibitor alpha
NF-kappa-B
inhibitor alpha
NF-kappa-B
inhibitor alpha
Nuclear factor
NF-kappa-B p105
subunit
Nuclear factor
NF-kappa-B p100
subunit
cAMP
Adenosine
Adenosine
GTP
GDP
Adenosine triphosphate
PP
i
cAMP
P
i
GTP
GDP
P
i
P
i
P
i
GTP
GDP
PIP2(16:0/16:0)
PIP3(16:0/16:0)
GTP
GDP
P
i
P
i
P
i
P
i
P
i
P
i
P
i
PIP3(16:0/16:0)
P
i
P
i
PIP3(16:0/16:0)
PIP3(16:0/16:0)
PIP3(16:0/16:0)
P
i
P
i
P
i
GDP
GDP
GTP
GTP
GTP
GTP
GDP
Magnesium
Magnesium
Magnesium
Zinc
Zinc
Magnesium
Magnesium
cAMP
Guanosine
diphosphate
Guanosine
triphosphate
Guanosine
triphosphate
Phosphate
Guanosine
diphosphate
Guanosine
triphosphate
Magnesium
Magnesium
Guanosine
triphosphate
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
Guanosine
triphosphate
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
Guanosine
triphosphate
Regulation of
glutamate and
Dopamine
release in the
brain
Coronary Artery
Vasodilation in
the heart
Apoptosis
Regulatory Subunit
Regulatory Subunit
Regulatory Subunit
Regulatory Subunit
Transcription
Transcription
Transcription
Transcription
Inhibition
Transcription
Nucleus
Activation
Activation
Activation
Activation
Extracellular Space
Intracellular Space
ADCY2
GNG12
GNAS
GNB1
BAD
ADORA2A
NFKB1
NFKB1
NFKB2
NFKB2
ADORA2A
ADORA2A
GNG12
GNB1
GNAS
GNAS
GNG12
GNB1
ADCY2
GNAS
PRKACB
PRKACB
CREB1
CREB1
RAPGEF3
RAP1A
RAP1A
RAPGEF3
MAP2K2
MAP2K2
RAP1A
BRAF
BRAF
MAP2K2
MAP2K2
MAPK1
MAPK1
ELK1
ELK1
RAPGEF2
RAPGEF2
HRAS
HRAS
PIK3CA
HRAS
PIK3CA
ARHGEF7
ARHGEF7
CDC42
CDC42
MAP3K4
MAP3K4
CDC42
MAP3K1
MAP3K1
MAP2K7
MAP2K7
MAPK8
MAPK8
JUN
JUN
CDC42
PAK1
PAK1
MAP2K6
MAP2K6
MAPK11
MAPK11
ATF2
ATF2
PARD6A
PRKCZ
CDC42
PARD6A
PRKCZ
RPS6KA1
RPS6KA1
BAD
PDPK1
PDPK1
AKT1
AKT1
AKT1
CHUK
IKBKB
CHUK
IKBKB
NFKBIA
NFKBIA
NFKBIA
NFKB1
NFKB2
cAMP
Adenosine
Adenosine
Guanosine
triphosphate
Guanosine
diphosphate
Adenosine
triphosphate
Pyrophosphate
cAMP
Phosphate
Guanosine
triphosphate
Guanosine
diphosphate
Phosphate
Phosphate
Phosphate
Guanosine
triphosphate
Guanosine
diphosphate
PIP2(16:0/16:0)
PIP3(16:0/16:0)
Guanosine
triphosphate
Guanosine
diphosphate
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
PIP3(16:0/16:0)
Phosphate
Phosphate
PIP3(16:0/16:0)
PIP3(16:0/16:0)
PIP3(16:0/16:0)
Phosphate
Phosphate
Phosphate
Guanosine
diphosphate
Guanosine
diphosphate
Guanosine
triphosphate
Guanosine
triphosphate
Guanosine
triphosphate
Guanosine
triphosphate
Guanosine
diphosphate
Regulation of
glutamate and
Dopamine
release in the
brain
Coronary Artery
Vasodilation in
the heart
Apoptosis