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Sodium/potassium- transporting ATPase subunit gamma ATPase, (Na+)/K+ transporting, beta 4 polypeptide K+ K+ Ca+ Sodium/potassium- transporting ATPase subunit beta-3 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Tropomyosin alpha-1 chain Tropomyosin beta chain Beta-1 adrenergic receptor cAMP-dependent protein kinase type I-alpha regulatory subunit Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Ryanodine receptor 2 Muscarinic acetylcholine receptor M2 Cardiac phospholamban Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-2 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Kv channel- interacting protein 2 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Potassium channel subfamily K member 1 Sodium/calcium exchanger 1 Potassium/sodium hyperpolarization- activated cyclic nucleotide- gated channel 4 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Sodium/calcium exchanger 1 cAMP-dependent protein kinase catalytic subunit alpha Sodium/potassium- transporting ATPase subunit beta-1 Inward rectifier potassium channel 2 Lidocaine 3-Hydroxylidocaine 3- Hydroxymonoethylglycinexylidide Monoethylglycinexylidide 2,6-Dimethylaniline Glycinexylidide 2-Amino-3-methylbenzoate 4-Hydroxy-2,6-dimethylaniline O2 NADPH H+ H2O NADP O2 NADH H2O Formaldehyde NAD Lidocaine Heme Heme Heme Heme Ca+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ Ca+ Ca+ Na+ Na+ Na+ Na+ K+ K+ Na+ Na+ Ca+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ ATP H2O Ca+ ADP Pi Ca+ Ca+ Troponin Troponin G-protein signalling cascade G-protein signalling cascade Muscle Contraction G protein- activated inward rectifier potassium channel 1 G protein- activated inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase Cardiac Myocyte Voltage-gated sodium channel (INa) Cardiac Muscle Skeletal Muscle Striated Muscle Cell Nucleus Mitochondrion Myofibril Sarcoplasmic Reticulum Myofibril Sarcolema Sarcoplasmic Reticulum Calcium binding to troponin displaces tropomyosin from the myosin binding sites on the actin filaments Myosin, with an ADP and phosphate attached, binds to actin to form a cross bridge. Myosin performs a powerstroke, drawing the actin filaments together. Many actin filaments pulled together at the same time leads to muscle contraction. Actin Filament Myosin Filament T-Tubule Depolarization Mitochondrion Single Sarcomere Functioning Unit