Toggle navigation
SMPDB
Browse SMPDB
Pathways
Table of Primary Pathways
Compounds
Proteins
Search
TextQuery Search Instructions
SMP-MAP Advanced Search
ChemQuery Structure Search
Molecular Weight Search
Sequence Search
About
About SMPDB
Release Notes
Citing SMPDB
Statistics
Other Databases
Pathway Legend
Pathway Category Definitions
PathWhiz
Downloads
Contact Us
Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loading Pathway...
Error: Pathway image not found.
Ca
+
Na
+
Ca
+
Ca
+
Na
+
K
+
K
+
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit alpha-4
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit alpha-3
Dimethylaniline
monooxygenase
[N-oxide-
forming] 3
UDP-
glucuronosyltransferase
1-4
UDP-
glucuronosyltransferase
1-9
Cytochrome P450
2A6
Cytochrome P450
2B6
Aldehyde
oxidase
Cytochrome P450
2A6
UDP-
glucuronosyltransferase
1-4
UDP-
glucuronosyltransferase
1-9
Cytochrome P450
2A6
Alpha-1A
adrenergic
receptor
5-
hydroxytryptamine
receptor 1A
D(1A) dopamine
receptor
Beta-endorphin
Mu-type opioid
receptor
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit alpha-4
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Potassium
voltage-gated
channel
subfamily D
member 2
Kv channel-
interacting
protein 2
Beta-endorphin
Glutamate
[NMDA] receptor
subunit zeta-1
Glutamate
[NMDA] receptor
subunit
epsilon-1
Glutamate
[NMDA] receptor
subunit 3A
Sodium-
dependent
noradrenaline
transporter
Sodium-
dependent
serotonin
transporter
Sodium-
dependent
dopamine
transporter
Pro-
opiomelanocortin
Neuroendocrine
convertase 2
Sodium/potassium-
transporting
ATPase subunit
alpha-1
Nicotine
Nicotine
Nicotine
Nornicotine
Norcotinine
Hydroxycotinine
trans-3-Hydroxycotinine
glucuronide
Cotinine
Cotinine N-oxide
5'-Hydroxycotinine
O
2
NADPH
H
+
Nicotine-1'-N-oxide
H
2
O
NADP
Uridine
diphosphate
glucuronic acid
Nicotine glucuronide
Uridine
5'-diphosphate
Nicotine imine
H
+
H
2
O
O
2
H
2
O
2
H
+
O
2
NADPH
H
+
H
2
O
NADP
Uridine
diphosphate
glucuronic acid
Cotinine glucuronide
Uridine
5'-diphosphate
O
2
NADH
H
2
O
Formaldehyde
NAD
FAD
Heme
Heme
FAD
Molybdopterin
2Fe-2S
Heme
Heme
Norepinephrine
Serotonin
Dopamine
Ca
+
Na
+
K
+
Ca
+
Ca
+
Norepinephrine
Serotonin
Na
+
Na
+
Na
+
Na
+
Dopamine
Na
+
Na
+
ATP
H
2
O
Na
+
K
+
ADP
P
i
Na
+
K
+
Sodium channel
protein type 10
subunit alpha
Neuronal
acetylcholine
receptor
subunit alpha-4
Sodium channel
subunit beta-1
Sodium/potassium-
transporting
ATPase subunit
alpha-3
Sodium/potassium-
transporting
ATPase subunit
beta-2
Sodium/potassium-
transporting
ATPase subunit
alpha-2
Sodium/potassium-
transporting
ATPase subunit
alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-1
Sodium/potassium-
transporting
ATPase subunit
gamma
Neuronal
acetylcholine
receptor
subunit alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-3
ATPase,
(Na+)/K+
transporting,
beta 4
polypeptide
Dendrite
Synaptic Vesicle
Presynaptic Neuron
Postsynaptic Neuron
Synaptic Cleft
Neuron
Neuron Axon
Action Potential
Membrane Potential (mV)
Resting Potential
-70
Time
+40
0
Depolarization
Peak Action Potential
Repolarization
Hyperpolarization