DNA
topoisomerase
2-alpha
Myeloperoxidase
Teniposide
Teniposide
O2
NADH
Teniposide catechol derivative
Formaldehyde
NAD
H2O
Teniposide catechol derivative
NAD
Teniposide o-quinone
derivative
NADH
Magnesium
Cytochrome P450
3A4
Cytochrome P450
3A5
Cell cycle
Heme
Heme
Oxidative DNA
Damage (Cell
Death)
DNA repair
Calcium
Heme
S- DNA replication
M- mitosis/ cell division
G2- growth, preparation for
mitosis and DNA repair
Cancer Cell
DNA strand break
G1- cell growth
Re-ligation of DNA strand
breaks cannot occur since
DNA toposiomerase II is
non-functional. This leads
to errors in DNA synthesis
Nucleus
Apoptosis
Errors in DNA synthesis
promotes apoptosis of the
cancer cell
Hepatocyte
Liver