335
Pathway
Trastuzumab Action Pathway
Trastuzumab is an anti-EGFR drug used in the treatment of HER2-positive breast cancer. EGFR is linked multiple signalling pathways involved in tumour growth and angiogenesis such as the Ras/Raf pathway and the PI3K/Akt pathways. These pathways ultimately lead to the activation of transcription factors such as Jun, Fos, and Myc, as well as cyclin D1, which stimulates cell growth and mitosis. Uncontrolled cell growth and mitosis leads to cancer. Trastuzumab acts as an anticancer drug by binding to the extracellular domain of the EGFR and preventing its activation by epidermal growth factor. This in turn inhibits downstream signalling and prevents tumour growth.
Drug Action
PW000255
Top
PathwayVisualizationContext271
400
800
#000099
PathwayVisualization175
335
Trastuzumab Pathway
Trastuzumab is an anti-EGFR drug used in the treatment of HER2-positive breast cancer. EGFR is linked multiple signalling pathways involved in tumour growth and angiogenesis such as the Ras/Raf pathway and the PI3K/Akt pathways. These pathways ultimately lead to the activation of transcription factors such as Jun, Fos, and Myc, as well as cyclin D1, which stimulates cell growth and mitosis. Uncontrolled cell growth and mitosis leads to cancer. Trastuzumab acts as an anticancer drug by binding to the extracellular domain of the EGFR and preventing its activation by epidermal growth factor. This in turn inhibits downstream signalling and prevents tumour growth.
Drug
1
555
Trastuzumab Inhibition of Epidermal growth factor receptor
InhibitorySubPathway
919
826
ProteinComplex
15
920
822
ProteinComplex
14
1533
20127143
Gazdar AF: Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy. Cancer Metastasis Rev. 2010 Mar;29(1):37-48. doi: 10.1007/s10555-010-9201-z.
335
Pathway
1534
20130423
Lurje G, Lenz HJ: EGFR signaling and drug discovery. Oncology. 2009;77(6):400-10. doi: 10.1159/000279388. Epub 2010 Feb 2.
335
Pathway
1
Cell
CL:0000000
1
Homo sapiens
9606
Eukaryote
Human
11
Extracellular Space
GO:0005615
1
Cytosol
GO:0005829
10
Cell Membrane
GO:0005886
36
Membrane
GO:0016020
15
11
1
PW_BS000015
2
1
1
1
PW_BS000002
14
10
1
PW_BS000014
228
36
1
PW_BS000024
308
10
1
1
PW_BS000024
5751
Trastuzumab
DB00072
1
3406
15
1351
Epidermal growth factor receptor
P00533
Isoform 2 may act as an antagonist of EGF action
HMDBP01456
EGFR
7p12
AY588246
1
2.7.10.1
3399
2
3407
14
11650
228
80850
308
826
Trastuzumab
1
PW_P000826
950
5751
1
822
Epidermal growth factor receptor
1
PW_P000822
946
1351
2
2888
5751
15
159
false
45
170
8
subunit
regular
150
70
2889
1351
14
80
false
285
135
8
subunit
regular
200
130
2556
826
175
15
2877
2888
2557
822
175
14
2878
2889
10289
M195 205 C225 205 295 205 325 205
148
false
18
false
true
M 295 200 L 295 185 L 295 170
10290
M325 205 C295 205 225 205 195 205
5
true
18
614
555
175
14
true
225
80
16
regular
287
2556
10289
Left
288
2557
10290
Right
476
M400 145 C400 95 450 45 500 45 C543 45 598 45 641 45 C691 45 741 95 741 145 C741 177 741 217 741 249 C741 299 691 349 641 349 C598 349 543 349 500 349 C450 349 400 299 400 249 C400 217 400 177 400 145
1
true
6
341.0
304.0