DNA
topoisomerase 1
Multidrug
resistance
protein 1
Solute carrier
organic anion
transporter
family member
1B1
Multidrug
resistance-
associated
protein 1
Multidrug
resistance
protein 1
Canalicular
multispecific
organic anion
transporter 1
Canalicular
multispecific
organic anion
transporter 1
ATP-binding
cassette
sub-family G
member 2
Multidrug
resistance
protein 1
Canalicular
multispecific
organic anion
transporter 1
Cytochrome P450
3A4
Cytochrome P450
3A5
Cytochrome P450
3A4
Liver
carboxylesterase
1
Cocaine
esterase
UDP-
glucuronosyltransferase
1-10
UDP-
glucuronosyltransferase
1-1
UDP-
glucuronosyltransferase
1-9
UDP-
glucuronosyltransferase
1-1
Liver
carboxylesterase
1
Cocaine
esterase
Liver
carboxylesterase
1
Cocaine
esterase
Cholinesterase
Liver
carboxylesterase
1
Cocaine
esterase
Irinotecan
SN-38
Irinotecan
SN-38
SN-38 Glucuronide
SN-38 Glucuronide
NPC
APC
H2O
Uridine
diphosphate
glucuronic acid
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
Uridine
5'-diphosphate
H2O
H2O
Irinotecan
H2O
SN-38
H2O
ATP
Pi
ADP
H2O
ATP
Pi
ADP
H2O
ATP
Pi
ADP
H2O
ATP
Pi
ADP
H2O
ATP
Pi
ADP
H2O
ATP
Pi
ADP
H2O
ATP
Pi
ADP
H2O
ATP
Pi
ADP
Heme
Heme
Heme
Carboxylate
Carboxylate
Carboxylate
Carboxylate
Nucleus
Bacterial Glucuronidation