6022
PubChem-compound
7722-84-1
CAS
PW000586
PathWhiz
Q9H244
UniProt
Transport190
false
Clopidogrel (→) Transport: Homo sapiens, Intestine, Epithelial Cell to Homo sapiens, Liver, Cell
LEFT_TO_RIGHT
Endoplasmic Reticulum Membrane
937
ChemSpider
CPD-8587
BioCyc
Platelet
BiologicalState29
Homo sapiens, Liver
1.0
1.0
HMDB0003125
HMDB
HYDROGEN-PEROXIDE
BioCyc
SMILES
O
SMILES
OO
Adenosine triphosphate
HMDB0001341
HMDB
Cytochrome P450 1A2
Clopidogrel
Cytochrome P450 3A4
HMDB0000538
HMDB
Endothelium
Cytochrome P450 2B6
Cytochrome P450 3A5
Water
ATP
BioCyc
1.0
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Multidrug resistance protein 1
763
ChemSpider
1.14.13.-
false
1.14.13.-
2-Oxoclopidogrel → Active Metabolite of Clopidogrel
LEFT_TO_RIGHT
ReactionCoupledTransportCatalysis69
ACTIVATION
SMILES
[H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl
ADP
BioCyc
2-Oxoclopidogrel
1.14.14.1
false
1.14.14.1
Clopidogrel + Oxygen + Water → 2-Oxoclopidogrel + Hydrogen peroxide
LEFT_TO_RIGHT
P33261
UniProt
Active Metabolite of Clopidogrel
784
PubChem-compound
CHEBI:15422
ChEBI
SubPathwayControl562
SubPathway562Control
InhibitorySubPathwayControl
BTO:0000759
BRENDA TISSUE ONTOLOGY
1.0
P2Y purinoceptor 12
1.0
Homo sapiens
CL:0000066
CELL TYPE ONTOLOGY
5742
ChemSpider
Multidrug resistance protein 1
7732-18-5
CAS
1.0
1.0
ReactionCatalysis1500
ACTIVATION
952
ChemSpider
Water
GO:0005829
GENE ONTOLOGY
O2
Oxygen
31.98983
Hydrogen peroxide
ReactionCatalysis1502
ACTIVATION
ReactionCatalysis1501
ACTIVATION
ReactionCatalysis1867
ACTIVATION
GO:0005789
GENE ONTOLOGY
C16H16ClNO3S
2-Oxoclopidogrel
337.05396
2.0
BTO:0000648
BRENDA TISSUE ONTOLOGY
Clopidogrel Metabolism Pathway
113665-84-2
CAS
Serum paraoxonase/arylesterase 1
SMILES
COC(=O)[C@@H](N1CCC(S)=C(CC(O)=O)C1)C1=CC=CC=C1Cl
P11712
UniProt
BiologicalState16
Homo sapiens, Endothelium , Platelet
Phosphate
C10H16N5O13P3
Adenosine triphosphate
506.99576
P27169
UniProt
ReactionCatalysis1508
ACTIVATION
O4P
Phosphate
94.95342
1.0
CHEBI:16240
ChEBI
Clopidogrel
ReactionCatalysis1509
ACTIVATION
CL:0000233
CELL TYPE ONTOLOGY
Cytochrome P450 2C9
CHEBI:16761
ChEBI
Cytochrome P450 2C19
7782-44-7
CAS
ReactionCatalysis1511
ACTIVATION
HMDB0001377
HMDB
ReactionCatalysis1510
ACTIVATION
ReactionCatalysis1512
ACTIVATION
Cytochrome P450 2C19
3.6.3.44
false
3.6.3.44
Adenosine triphosphate + Clopidogrel + Water → Adenosine diphosphate + Clopidogrel + Phosphate
LEFT_TO_RIGHT
P20815
UniProt
Epithelial Cell
P20813
UniProt
9606
TAXONOMY
962
PubChem-compound
5800
ChemSpider
Cytosol
CPD-6641
BioCyc
2-Oxoclopidogrel
SMILES
O=O
SMILES
[O-]P([O-])([O-])=O
SMILES
COC(=O)[C@@H](N1CCC2SC(=O)C=C2C1)C1=CC=CC=C1Cl
Cytochrome P450 2B6
Cytochrome P450 3A5
GO:0005886
GENE ONTOLOGY
BiologicalState75
Homo sapiens, Intestine, Epithelial Cell
Serum paraoxonase/arylesterase 1
HMDB0002111
HMDB
Clopidogrel
Cell Membrane
CHEBI:15377
ChEBI
C00009
KEGG Compound
C00008
KEGG Compound
P05177
UniProt
C00007
KEGG Compound
CHEBI:15379
ChEBI
Oxygen
54632
ChemSpider
C16H18ClNO4S
Active Metabolite of Clopidogrel
355.0645
14265-44-2
CAS
P08684
UniProt
1.0
SMP0000610
SMPDB
56848893
PubChem-compound
C00001
KEGG Compound
58-64-0
CAS
HMDB0001429
HMDB
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
1.0
CHEBI:37941
ChEBI
Active Metabolite of Clopidogrel
SubPathwayInhibitor
P2Y purinoceptor 12
SubPathwayInhibition
CHEBI:18367
ChEBI
1032
ChemSpider
Liver
C00002
KEGG Compound
Cytochrome P450 1A2
1.0
Intestine
Cytochrome P450 3A4
Active Metabolite of Clopidogrel Inhibition of P2Y purinoceptor 12
InhibitorySubPathway
1.0
1.0
HMDB0013929
HMDB
28518812
ChemSpider
Serum paraoxonase/arylesterase 1
Extracellular Space
H2O
Water
18.010565
H2O2
Hydrogen peroxide
34.005478
5957
PubChem-compound
60606
PubChem-compound
Cytochrome P450 2B6
1061
PubChem-compound
Transport189
false
Clopidogrel (→) Transport: Homo sapiens, Intestine, Epithelial Cell, Cytosol to Homo sapiens, Intestine
LEFT_TO_RIGHT
977
PubChem-compound
Multidrug resistance protein 1
HMDB0061272
HMDB
56-65-5
CAS
C00027
KEGG Compound
P08183
UniProt
Cytochrome P450 2C9
Adenosine diphosphate
1.0
Clopidogrel
C10H15N5O10P2
Adenosine diphosphate
427.02942
GO:0005615
GENE ONTOLOGY
BTO:0000393
BRENDA TISSUE ONTOLOGY
HMDB0005011
HMDB
Cytochrome P450 2C19
TransportCatalysis144
ACTIVATION
C16H16ClNO2S
Clopidogrel
321.05902