184PathwayCimetidine Metabolism PathwayCimetidine binds to histamine H2-receptors located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.Drug MetabolismPW000593CenterPathwayVisualizationContext6639001000#000099PathwayVisualization242184Cimetidine PathwayCimetidine binds to histamine H2-receptors located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.Drug18022570417Bertaccini G, Coruzzi G: Control of gastric acid secretion by histamine H2 receptor antagonists and anticholinergics. Pharmacol Res. 1989 Jul-Aug;21(4):339-52.184Pathway803Cimetidine. (2009). e-CPS (online version of Compendium of Pharmaceuticals and Specialties). Retrieved July 2, 2009.184Pathway8046152495Pounder RE: Histamine H2-receptor antagonists and gastric acid secretion. Pharmacol Ther. 1984;26(2):221-34.184Pathway1CellCL:000000014Parietal CellCL:00001621Homo sapiens9606EukaryoteHuman10Cell MembraneGO:000588611Extracellular SpaceGO:00056151CytosolGO:000582938Apical cell membraneGO:001632428StomachBTO:00013071552614101PW_BS00001415111PW_BS0000152111PW_BS0000026592838114PW_BS0005089004CimetidineHMDB0014644A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. [PubChem]51481-61-9C06952275636992654DB00501C\N=C(\NCCSCC1=C(C)NC=N1)NC#NC10H16N6SInChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)AQIXAKUUQRKLND-UHFFFAOYSA-N(Z)-N-cyano-N''-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine252.339252.115715232-2.493tagamet HB01Cimetidine hcl;1-cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine;2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine;Cimetag;Cimetidina;Cimetidinum;N''-cyano-n-methyl-n'-(2-{[(5-methyl-1h-imidazol-4-yl)methyl]thio}ethyl)guanidine;N-cyano-n'-methyl-n''-(2-([(5-methyl-1h-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine;Tagamet hb 200;UlcerfenPW_C009004Cimetid1816Histamine H2 receptorP25021The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathwayHMDBP02157HRH25q35.2AB023486131541441521541602136155659770Histamine H2 receptor1PW_P000770868181611782falsePW_R001782Right667490041Compoundfalse66757701ProteinComplexfalse69759004157false2558510regular200190302718161480false2504108subunitregular20013026637702423016302710573M455 180 C485 180 418.5 103 442.5 120 5true1810574M355 435 C355 409 355 336 355 275 148false18falsetrueM 500 400 L 515 400 L 530 400204024217827093697510573Left43266310574Right818174725550.80.80230292758491M105 580 C105 530 155 480 205 480 C294 480 409 480 498 480 C548 480 598 530 598 580 C598 617 598 665 598 702 C598 752 548 802 498 802 C409 802 294 802 205 802 C155 802 105 752 105 702 C105 665 105 617 105 580 1true6493.0322.03928403843736668866404631830