Reference/ChemSpider 3548
type: UnificationXref
id: 3548
db: ChemSpider

Reaction1938
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040578/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040579/Stoichiometry/1.0
right: Glycinexylidide
spontaneous: false
left: Monoethylglycinexylidide
name: Monoethylglycinexylidide → Glycinexylidide
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reaction1936
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040578/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040577/Stoichiometry/1.0
right: 3-Hydroxymonoethylglycinexylidide
spontaneous: false
left: Monoethylglycinexylidide
name: Monoethylglycinexylidide → 3-Hydroxymonoethylglycinexylidide
conversion direction: LEFT_TO_RIGHT

Reaction1934
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040576/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040577/Stoichiometry/1.0
right: 3-Hydroxymonoethylglycinexylidide
spontaneous: false
left: 3-Hydroxylidocaine
name: 3-Hydroxylidocaine → 3-Hydroxymonoethylglycinexylidide
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 3676
type: UnificationXref
id: 3676
db: PubChem-compound

Compound/PW C040582/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxy-2,6-dimethylaniline
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 70478
type: UnificationXref
id: 70478
db: ChemSpider

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/KEGG Compound C07073
type: UnificationXref
id: C07073
db: KEGG Compound

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C008817 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040576 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 3-Hydroxylidocaine
right: NADP
spontaneous: false
EC number: 1.14.14.1
left: Oxygen
left: Lidocaine
left: NADPH
left: Hydrogen Ion
name: Hydrogen Ion + Lidocaine + NADPH + Oxygen → 3-Hydroxylidocaine + NADP + Water
conversion direction: LEFT_TO_RIGHT

Cytochrome P450 3A4
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 3A4

Reaction1930
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040578/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040580/Stoichiometry/1.0
right: 2,6-Dimethylaniline
spontaneous: false
left: Monoethylglycinexylidide
name: Monoethylglycinexylidide → 2,6-Dimethylaniline
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 222828
type: UnificationXref
id: CHEBI:222828
db: ChEBI

Sodium channel protein type 10 subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Sodium channel protein type 10 subunit alpha

Cytochrome P450 1A2
type: ProteinReference
xref: Reference/UniProt P05177
organism: BiologicalState10

Reference/PubChem-compound 87833
type: UnificationXref
id: 87833
db: PubChem-compound

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C008817 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040578 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001102 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Monoethylglycinexylidide
right: Formaldehyde
right: NAD
spontaneous: false
EC number: 1.14.14.1
left: NADH
left: Oxygen
left: Lidocaine
name: Lidocaine + NADH + Oxygen → Formaldehyde + Monoethylglycinexylidide + NAD + Water
conversion direction: LEFT_TO_RIGHT

Reaction1926
type: BiochemicalReaction
participant stoichiometry: Compound/PW C008817/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040580/Stoichiometry/1.0
right: 2,6-Dimethylaniline
spontaneous: false
left: Lidocaine
name: Lidocaine → 2,6-Dimethylaniline
conversion direction: LEFT_TO_RIGHT

Cytochrome P450 3A4
type: ProteinReference
xref: Reference/UniProt P08684
organism: BiologicalState10

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Reference/ChemSpider 22824
type: UnificationXref
id: 22824
db: ChemSpider

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Compound/PW C040579/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycinexylidide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/CAS 34604-56-3
type: UnificationXref
id: 34604-56-3
db: CAS

Compound/PW C008817 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lidocaine
stoichiometric coefficient: 1.0

Compound/PW C040578/Stoichiometry/1.0
type: Stoichiometry
physical entity: Monoethylglycinexylidide
stoichiometric coefficient: 1.0

Reference/ChemSpider 2283781
type: UnificationXref
id: 2283781
db: ChemSpider

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Compound/PW C040578 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Monoethylglycinexylidide
stoichiometric coefficient: 1.0

Reference/ChemSpider 142125
type: UnificationXref
id: 142125
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Sodium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q07699
organism: BiologicalState73

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Monoethylglycinexylidide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Monoethylglycinexylidide

Formaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16842
xref: Reference/BioCyc FORMALDEHYDE
xref: Reference/HMDB HMDB0001426
xref: Reference/PubChem-compound 712
xref: Reference/ChemSpider 692
xref: Reference/KEGG Compound C00067
xref: Reference/CAS 50-00-0
chemical formula: CH2O
molecular weight: 30.010565
structure: ChemicalStructure/PW C001102

Reference/ChemSpider 69010
type: UnificationXref
id: 69010
db: ChemSpider

Compound/PW C001102 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formaldehyde
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Compound/PW C040581/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Amino-3-methylbenzoate
stoichiometric coefficient: 1.0

Transport266
type: Transport
participant stoichiometry: Compound/PW C008817 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008817 Extracellular Space/Stoichiometry/1.0
right: Lidocaine
spontaneous: false
left: Lidocaine
name: Lidocaine (→) Transport: Homo sapiens, Liver, Cell, Endoplasmic Reticulum Membrane to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Sodium channel protein type 10 subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9Y5Y9
organism: BiologicalState73

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Compound/PW C040576/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxylidocaine
stoichiometric coefficient: 1.0

Reaction1943
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040581/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040580/Stoichiometry/1.0
right: 2-Amino-3-methylbenzoate
spontaneous: false
left: 2,6-Dimethylaniline
name: 2,6-Dimethylaniline → 2-Amino-3-methylbenzoate
conversion direction: LEFT_TO_RIGHT

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reaction1944
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040580/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040582/Stoichiometry/1.0
right: 4-Hydroxy-2,6-dimethylaniline
spontaneous: false
left: 2,6-Dimethylaniline
name: 2,6-Dimethylaniline → 4-Hydroxy-2,6-dimethylaniline
conversion direction: LEFT_TO_RIGHT

Reaction1942
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040580/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040579/Stoichiometry/1.0
right: 2,6-Dimethylaniline
spontaneous: false
left: Glycinexylidide
name: Glycinexylidide → 2,6-Dimethylaniline
conversion direction: LEFT_TO_RIGHT

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Lidocaine (Local Anaesthetic) Metabolism Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2398
pathway order: PathwayEnzymeReaction/2420
pathway order: PathwayEnzymeReaction/3410
pathway order: PathwaySubPathway/502
pathway order: PathwayTransport/3411
pathway order: PathwayEnzymeReaction/2482
pathway order: PathwayEnzymeReaction/2415
pathway order: PathwayEnzymeReaction/2417
pathway order: PathwayEnzymeReaction/3407
pathway order: PathwayEnzymeReaction/3408
pathway order: PathwayEnzymeReaction/2412
pathway order: PathwayEnzymeReaction/2403
pathway order: PathwayEnzymeReaction/2408
pathway order: PathwayEnzymeReaction/3409
pathway component: Reaction1938
pathway component: 1.14.14.1
pathway component: Transport266
pathway component: Reaction1936
pathway component: Reaction1926
pathway component: Reaction1934
pathway component: SubPathwayControl502
pathway component: ReactionCatalysis1786
pathway component: ReactionCatalysis1785
pathway component: ReactionCatalysis1768
pathway component: ReactionCatalysis1769
pathway component: Reaction1943
pathway component: Reaction1944
pathway component: Reaction1930
pathway component: Reaction1942
xref: Reference/PathWhiz PW000596
xref: Reference/SMPDB SMP0000620
organism: Homo sapiens

Compound/PW C008817/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lidocaine
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/BioCyc FORMALDEHYDE
type: UnificationXref
id: FORMALDEHYDE
db: BioCyc

Sodium channel
type: Complex
component stoichiometry: Protein/4288 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/4299 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Sodium channel subunit beta-1
component: Sodium channel protein type 10 subunit alpha
name: SubPathwayInhibition

Reference/PubChem-compound 161824
type: UnificationXref
id: 161824
db: PubChem-compound

SubPathwayControl502
type: Interaction
name: SubPathway502Control
name: InhibitorySubPathwayControl
participant: Sodium channel
participant: Lidocaine
participant: Lidocaine inhibition of sodium channel

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Lidocaine
type: SmallMolecule
entity reference: Lidocaine
name: SubPathwayInhibitor

Reference/ChemSpider 79241
type: UnificationXref
id: 79241
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ReactionCatalysis1768
type: Catalysis
controller: Cytochrome P450 1A2
controlled: 1.14.14.1
control type: ACTIVATION

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C001102
type: ChemicalStructure
structure format: SMILES
structure data: C=O

Reference/HMDB HMDB0001426
type: UnificationXref
id: HMDB0001426
db: HMDB

Reference/ChemSpider 692
type: UnificationXref
id: 692
db: ChemSpider

ReactionCatalysis1769
type: Catalysis
controller: Cytochrome P450 3A4
controlled: 1.14.14.1
control type: ACTIVATION

Reference/PubChem-compound 78101
type: UnificationXref
id: 78101
db: PubChem-compound

Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

BiologicalState73
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Neuron

Reference/KEGG Compound C11004
type: UnificationXref
id: C11004
db: KEGG Compound

NADH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADH

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Formaldehyde
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Formaldehyde

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Cytochrome P450 1A2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 1A2

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Protein/4288 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel subunit beta-1
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/ChemSpider 6630
type: UnificationXref
id: 6630
db: ChemSpider

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/ChEBI CHEBI 357241
type: UnificationXref
id: CHEBI:357241
db: ChEBI

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

ReactionCatalysis1786
type: Catalysis
controller: Cytochrome P450 3A4
controlled: 1.14.14.1
control type: ACTIVATION

ReactionCatalysis1785
type: Catalysis
controller: Cytochrome P450 1A2
controlled: 1.14.14.1
control type: ACTIVATION

Lidocaine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Lidocaine

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Compound/PW C040577/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxymonoethylglycinexylidide
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000620
type: UnificationXref
id: SMP0000620
db: SMPDB

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040576
type: ChemicalStructure
structure format: SMILES
structure data: CCN(CC)CC(=O)NC1=C(C)C=CC(O)=C1C

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChEBI CHEBI 16842
type: UnificationXref
id: CHEBI:16842
db: ChEBI

ChemicalStructure/PW C040579
type: ChemicalStructure
structure format: SMILES
structure data: CC1=CC=CC(C)=C1NC(=O)CN

ChemicalStructure/PW C040578
type: ChemicalStructure
structure format: SMILES
structure data: CCNCC(=O)NC1=C(C)C=CC=C1C

ChemicalStructure/PW C040577
type: ChemicalStructure
structure format: SMILES
structure data: CCNCC(=O)NC1=C(C)C=CC(O)=C1C

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/PubChem-compound 3015693
type: UnificationXref
id: 3015693
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/PW C040580/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,6-Dimethylaniline
stoichiometric coefficient: 1.0

Reference/CAS 137-58-6
type: UnificationXref
id: 137-58-6
db: CAS

Reference/PubChem-compound 24415
type: UnificationXref
id: 24415
db: PubChem-compound

ChemicalStructure/PW C040582
type: ChemicalStructure
structure format: SMILES
structure data: CC1=CC(O)=CC(C)=C1N

Reference/CAS 34604-55-2
type: UnificationXref
id: 34604-55-2
db: CAS

ChemicalStructure/PW C040581
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(N)C(=CC=C1)C(O)=O

ChemicalStructure/PW C040580
type: ChemicalStructure
structure format: SMILES
structure data: CC1=CC=CC(C)=C1N

Lidocaine inhibition of sodium channel
type: Pathway
name: InhibitorySubPathway

Reference/CAS 7728-40-7
type: UnificationXref
id: 7728-40-7
db: CAS

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9Y5Y9
type: UnificationXref
id: Q9Y5Y9
db: UniProt

Reference/HMDB HMDB0060681
type: UnificationXref
id: HMDB0060681
db: HMDB

4-Hydroxy-2,6-dimethylaniline
type: SmallMolecule
entity reference: 4-Hydroxy-2,6-dimethylaniline

3-Hydroxylidocaine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C16560
xref: Reference/PubChem-compound 161824
xref: Reference/ChemSpider 142125
xref: Reference/CAS 34604-55-2
xref: Reference/HMDB HMDB0060655
chemical formula: C14H22N2O2
molecular weight: 250.16812
structure: ChemicalStructure/PW C040576

Reference/HMDB HMDB0014426
type: UnificationXref
id: HMDB0014426
db: HMDB

3-Hydroxymonoethylglycinexylidide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C16572
xref: Reference/ChemSpider 2283781
xref: Reference/PubChem-compound 3015693
xref: Reference/HMDB HMDB0060678
xref: Reference/CAS 34604-56-3
chemical formula: C12H18N2O2
molecular weight: 222.13683
structure: ChemicalStructure/PW C040577

Monoethylglycinexylidide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C16561
xref: Reference/ChemSpider 22824
xref: Reference/CAS 7728-40-7
xref: Reference/HMDB HMDB0060656
xref: Reference/ChEBI CHEBI 222828
xref: Reference/PubChem-compound 24415
chemical formula: C12H18N2O
molecular weight: 206.1419
structure: ChemicalStructure/PW C040578

Reference/HMDB HMDB0060680
type: UnificationXref
id: HMDB0060680
db: HMDB

Reference/CAS 3096-70-6
type: UnificationXref
id: 3096-70-6
db: CAS

Glycinexylidide
type: SmallMoleculeReference
xref: Reference/CAS 18865-38-8
xref: Reference/PubChem-compound 87833
xref: Reference/HMDB HMDB0060679
xref: Reference/KEGG Compound C16569
xref: Reference/ChemSpider 79241
xref: Reference/ChEBI CHEBI 357241
chemical formula: C10H14N2O
molecular weight: 178.11061
structure: ChemicalStructure/PW C040579

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/PubChem-compound 6896
type: UnificationXref
id: 6896
db: PubChem-compound

3-Hydroxylidocaine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 3-Hydroxylidocaine

NAD
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NAD

Reference/HMDB HMDB0060679
type: UnificationXref
id: HMDB0060679
db: HMDB

Reference/HMDB HMDB0060678
type: UnificationXref
id: HMDB0060678
db: HMDB

2,6-Dimethylaniline
type: SmallMolecule
entity reference: 2,6-Dimethylaniline

2-Amino-3-methylbenzoate
type: SmallMolecule
entity reference: 2-Amino-3-methylbenzoate

2,6-Dimethylaniline
type: SmallMoleculeReference
xref: Reference/CAS 87-62-7
xref: Reference/ChEBI CHEBI 28738
xref: Reference/ChemSpider 6630
xref: Reference/PubChem-compound 6896
xref: Reference/HMDB HMDB0060677
xref: Reference/KEGG Compound C11004
chemical formula: C8H11N
molecular weight: 121.08915
structure: ChemicalStructure/PW C040580

Reference/HMDB HMDB0060677
type: UnificationXref
id: HMDB0060677
db: HMDB

2-Amino-3-methylbenzoate
type: SmallMoleculeReference
xref: Reference/CAS 4389-45-1
xref: Reference/KEGG Compound C16571
xref: Reference/ChemSpider 70478
xref: Reference/HMDB HMDB0060680
xref: Reference/PubChem-compound 78101
chemical formula: C8H9NO2
molecular weight: 151.06332
structure: ChemicalStructure/PW C040581

4-Hydroxy-2,6-dimethylaniline
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0060681
xref: Reference/ChEBI CHEBI 55545
xref: Reference/CAS 3096-70-6
xref: Reference/KEGG Compound C16570
xref: Reference/PubChem-compound 76543
xref: Reference/ChemSpider 69010
chemical formula: C8H11NO
molecular weight: 137.08406
structure: ChemicalStructure/PW C040582

Lidocaine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Lidocaine

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChEBI CHEBI 28738
type: UnificationXref
id: CHEBI:28738
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/PubChem-compound 76543
type: UnificationXref
id: 76543
db: PubChem-compound

BiologicalState10
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Reference/KEGG Compound C00067
type: UnificationXref
id: C00067
db: KEGG Compound

Lidocaine
type: SmallMoleculeReference
xref: Reference/ChemSpider 3548
xref: Reference/HMDB HMDB0014426
xref: Reference/ChEBI CHEBI 6456
xref: Reference/PubChem-compound 3676
xref: Reference/KEGG Compound C07073
xref: Reference/CAS 137-58-6
chemical formula: C14H22N2O
molecular weight: 234.17322
structure: ChemicalStructure/PW C008817

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/CAS 18865-38-8
type: UnificationXref
id: 18865-38-8
db: CAS

Reference/CAS 87-62-7
type: UnificationXref
id: 87-62-7
db: CAS

Reference/HMDB HMDB0060656
type: UnificationXref
id: HMDB0060656
db: HMDB

Reference/HMDB HMDB0060655
type: UnificationXref
id: HMDB0060655
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/ChEBI CHEBI 6456
type: UnificationXref
id: CHEBI:6456
db: ChEBI

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 4389-45-1
type: UnificationXref
id: 4389-45-1
db: CAS

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P05177
type: UnificationXref
id: P05177
db: UniProt

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/UniProt P08684
type: UnificationXref
id: P08684
db: UniProt

Compound/PW C008817 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lidocaine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 712
type: UnificationXref
id: 712
db: PubChem-compound

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

ChemicalStructure/PW C008817
type: ChemicalStructure
structure format: SMILES
structure data: CCN(CC)CC(=O)NC1=C(C)C=CC=C1C

Reference/ChEBI CHEBI 55545
type: UnificationXref
id: CHEBI:55545
db: ChEBI

Reference/KEGG Compound C16560
type: UnificationXref
id: C16560
db: KEGG Compound

Reference/KEGG Compound C16561
type: UnificationXref
id: C16561
db: KEGG Compound

3-Hydroxylidocaine
type: SmallMolecule
entity reference: 3-Hydroxylidocaine

3-Hydroxymonoethylglycinexylidide
type: SmallMolecule
entity reference: 3-Hydroxymonoethylglycinexylidide

Monoethylglycinexylidide
type: SmallMolecule
entity reference: Monoethylglycinexylidide

Glycinexylidide
type: SmallMolecule
entity reference: Glycinexylidide

Reference/UniProt Q07699
type: UnificationXref
id: Q07699
db: UniProt

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C040576 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxylidocaine
stoichiometric coefficient: 1.0

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PathWhiz PW000596
type: UnificationXref
id: PW000596
db: PathWhiz

Reference/KEGG Compound C16571
type: UnificationXref
id: C16571
db: KEGG Compound

Reference/KEGG Compound C16572
type: UnificationXref
id: C16572
db: KEGG Compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/KEGG Compound C16570
type: UnificationXref
id: C16570
db: KEGG Compound

Sodium channel subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium channel subunit beta-1

Reference/CAS 50-00-0
type: UnificationXref
id: 50-00-0
db: CAS

Protein/4299 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel protein type 10 subunit alpha
stoichiometric coefficient: 1.0

Reference/KEGG Compound C16569
type: UnificationXref
id: C16569
db: KEGG Compound