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Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit alpha-4
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit alpha-3
Dimethylaniline
monooxygenase
[N-oxide-
forming] 3
UDP-
glucuronosyltransferase
1-4
UDP-
glucuronosyltransferase
1-9
Cytochrome P450
2A6
Cytochrome P450
2B6
Aldehyde
oxidase
Cytochrome P450
2A6
UDP-
glucuronosyltransferase
1-4
UDP-
glucuronosyltransferase
1-9
Cytochrome P450
2A6
Nicotine
Nicotine
Nicotine
Nornicotine
Norcotinine
Hydroxycotinine
trans-3-Hydroxycotinine
glucuronide
Cotinine
Cotinine N-oxide
5'-Hydroxycotinine
O
2
NADPH
H
+
Nicotine-1'-N-oxide
H
2
O
NADP
Uridine
diphosphate
glucuronic acid
Nicotine glucuronide
Uridine
5'-diphosphate
Nicotine imine
H
+
H
2
O
O
2
H
2
O
2
H
+
O
2
NADPH
H
+
H
2
O
NADP
Uridine
diphosphate
glucuronic acid
Cotinine glucuronide
Uridine
5'-diphosphate
O
2
NADH
H
2
O
Formaldehyde
NAD
FAD
Heme
Heme
FAD
Molybdopterin
2Fe-2S
Heme
Heme
Dendrite
Endoplasmic Reticulum
Unknown
Unknown
Unknown
Unknown
FMO3
UGT1A4
UGT1A9
CYP2A6
CYP2B6
AOX1
CYP2A6
UGT1A4
UGT1A9
CYP2A6
Nicotine
Nicotine
Nicotine
Nornicotine
Norcotinine
Hydroxycotinine
trans-3-
Hydroxycotinine
glucuronide
Cotinine
Cotinine
N-oxide
5'-
Hydroxycotinine
Oxygen
NADPH
Hydrogen Ion
Nicotine-1'-
N-oxide
Water
NADP
Uridine
diphosphate
glucuronic acid
Nicotine
glucuronide
Uridine
5'-diphosphate
Nicotine imine
Hydrogen Ion
Water
Oxygen
Hydrogen
peroxide
Hydrogen Ion
Oxygen
NADPH
Hydrogen Ion
Water
NADP
Uridine
diphosphate
glucuronic acid
Cotinine
glucuronide
Uridine
5'-diphosphate
Oxygen
NADH
Water
Formaldehyde
NAD