Solute carrier
family 22
member 1
Cytochrome P450
2B6
Cytochrome P450
3A4
Cytochrome P450
2B6
Cytochrome P450
3A4
Cytochrome P450
2D6
UDP-
glucuronosyltransferase
2B7
UDP-
glucuronosyltransferase
1-8
Cytochrome P450
2D6
Cytochrome P450
2D6
Canalicular
multispecific
organic anion
transporter 1
O-Desmethyltramadol
Tramadol
O2
NADH
N-Desmethyltramadol
Formaldehyde
NAD
H2O
O2
NADH
N,N-Didesmethyltramadol
Formaldehyde
NAD
H2O
O2
NADH
O-Desmethyltramadol
Formaldehyde
NAD
H2O
Uridine
diphosphate
glucuronic acid
O-Desmethyltramadol
glucuronide
Uridine
5'-diphosphate
O2
NADH
N,O-Didesmethyltramadol
Formaldehyde
NAD
H2O
NADH
O2
Formaldehyde
H2O
NAD
N,N,O-Tridesmethyltramadol
H2O
ATP
O-Desmethyltramadol
glucuronide
H+
ADP
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Endoplasmic Reticulum
Membrane