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Table of Primary Pathways
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Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Cytochrome P450
2D6
Alcohol
dehydrogenase
1A
Alcohol
dehydrogenase
1B
Cytochrome P450
2C9
Cytochrome P450
3A4
UDP-
glucuronosyltransferase
1-10
Celecoxib
Celecoxib
Hydroxycelecoxib
Carboxycelecoxib
O
2
NADPH
H
+
H
2
O
NADP
Uridine
diphosphate
glucuronic acid
Celecoxib glucuronide
Uridine
5'-diphosphate
Heme
Heme
Heme
Zinc
Zinc
Heme
Heme
Endoplasmic Reticulum
PTGS1
PTGS2
CYP2D6
ADH1A
ADH1B
CYP2C9
CYP3A4
UGT1A10
Celecoxib
Celecoxib
Hydroxycelecoxib
Carboxycelecoxib
Oxygen
NADPH
Hydrogen Ion
Water
NADP
Uridine
diphosphate
glucuronic acid
Celecoxib
glucuronide
Uridine
5'-diphosphate
PTGS1
PTGS2
CYP2D6
ADH1A
ADH1B
CYP2C9
CYP3A4
UGT1A10
Celcoxb
Celcoxb
HCelcxb
Caroxyc
O
2
NADPH
H
+
H
2
O
NADP
UDPGlcA
CelGlu
UDP
Heme
Heme
Heme
Zinc
Zinc
Heme
Heme