ReactionCatalysis155
ACTIVATION
1.0
Fibrinogen beta chain
Coagulation factor V
4760
PubChem-compound
5284607
PubChem-compound
Fibrin (loose)
Phenindione inhibition of Vitamin K epoxide reductase complex subunit 1
SubPathway
82688
ChemSpider
ReactionCatalysis142
ACTIVATION
4447652
ChemSpider
SMP0000655
SMPDB
Fibrin (mesh)
ReactionCatalysis381
ACTIVATION
Prothrombin and coagulation factors VII, IX and X
Phenindione
SubPathwayInput
SMILES
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(O)C2=C(C=CC=C2)C(O)=C1C
P00488
UniProt
Vitamin K-dependent gamma-carboxylase
BTO:0000759
BRENDA TISSUE ONTOLOGY
P02671
UniProt
Fibrinogen gamma chain
Tenase complex
Coagulation factor VIII
Coagulation factor IX
ReactionCatalysis1103
ACTIVATION
2.3.2.13
false
2.3.2.13
Fibrin (loose) → Fibrin (mesh)
LEFT_TO_RIGHT
Coagulation factor VIII
ReactionCatalysis1105
ACTIVATION
HMDB0002972
HMDB
3.4.21.5
false
3.4.21.5
Fibrinogen → Fibrin (loose)
LEFT_TO_RIGHT
P02675
UniProt
1.1.4.1
false
1.1.4.1
Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone)
LEFT_TO_RIGHT
SMILES
O=C1C(C(=O)C2=CC=CC=C12)C1=CC=CC=C1
ReactionCatalysis1100
ACTIVATION
P02679
UniProt
1.0
Tissue factor
Collagen alpha-1(I) chain
ReactionCatalysis1115
ACTIVATION
3.4.21.5
false
3.4.21.5
Coagulation factor V → Coagulation factor Va
LEFT_TO_RIGHT
3.4.21.5
false
3.4.21.5
Coagulation factor VIII → Coagulation factor VIIIa
LEFT_TO_RIGHT
3.4.21.22
false
3.4.21.22
Coagulation factor X → Coagulation factor Xa
LEFT_TO_RIGHT
1.0
Precursors of Prothrombin and coagulation factors VII, IX, ad X
Reaction1389
false
Prothrombin → Thrombin
LEFT_TO_RIGHT
3.4.21.38
false
3.4.21.38
Coagulation factor XI → Coagulation factor XIa
LEFT_TO_RIGHT
ReactionCatalysis1110
ACTIVATION
SubPathwayControl184
ActivatingSubPathwayControl
SubPathway184Control
SubPathwayControl186
ActivatingSubPathwayControl
SubPathway186Control
SubPathwayControl188
ActivatingSubPathwayControl
SubPathway188Control
3.4.21.27
false
3.4.21.27
Coagulation factor IX → Coagulation factor IXa
LEFT_TO_RIGHT
Prothrombin and coagulation factors VII, IX and X
Vitamin K1 2,3-epoxide
84-80-0
CAS
91577
PubChem-compound
Coagulation factor X
Vitamin K epoxide reductase complex subunit 1
Coagulation factor VIIa
SubPathwayActivator
Liver
Plasminogen
83-12-5
CAS
25486-55-9
CAS
Coagulation factor IX
P03951
UniProt
P03952
UniProt
P00451
UniProt
1.0
Extracellular Space
Blood Vessel
BiologicalState51
Homo sapiens, Blood Vessel
PW000631
PathWhiz
HMDB0014641
HMDB
Coagulation factor XIIa
C07584
KEGG Compound
GO:0005615
GENE ONTOLOGY
XII activated to XIIa by Collagen
ActivatingSubPathway
Transport80
false
Prothrombin and coagulation factors VII, IX and X (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
XII activated to XIIa by Plasma kallikrein
ActivatingSubPathway
1.0
Coagulation factor X
CHEBI:28371
ChEBI
Plasma prekallikrein activated to Plasma kallikrein by XIIa
ActivatingSubPathway
C05849
KEGG Compound
4596
ChemSpider
Endoplasmic Reticulum Membrane
1.0
Coagulation factor XIII B chain
Tissue-type plasminogen activator
P00750
UniProt
4.1.1.90
false
4.1.1.90
Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X
LEFT_TO_RIGHT
1.0
Plasminogen
Activate Coagulatin factor VII to VIIa by binding to Tissue Factor
ActivatingSubPathway
C15H10O2
Phenindione
222.06808
4.1.1.90
false
4.1.1.90
Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide
LEFT_TO_RIGHT
3.4.21.68
false
3.4.21.68
Plasminogen → Plasmin
LEFT_TO_RIGHT
Fibrinogen alpha chain
Plasma kallikrein
SubPathwayActivation
C05850
KEGG Compound
Fibrinogen gamma chain
1.0
Coagulation factor XIII B chain
SubPathwayActivator
1.0
BTO:0001102
BRENDA TISSUE ONTOLOGY
1.0
3.4.21.7
false
3.4.21.7
Fibrin (mesh) → Fibrin degradation products
LEFT_TO_RIGHT
P38435
UniProt
Coagulation factor XIa
Coagulation factor XIII A chain
SubPathwayActivator
Coagulation factor X
Vitamin K epoxide reductase complex subunit 1
Coagulation factor VIIa
Homo sapiens
1.0
Vitamin K-dependent gamma-carboxylase
P13726
UniProt
GO:0005789
GENE ONTOLOGY
HMDB0004198
HMDB
Q9BQB6
UniProt
BiologicalState10
Homo sapiens, Liver
Fibrinogen
23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
BioCyc
C31H46O3
Vitamin K1 2,3-epoxide
466.3447
1.0
P08709
UniProt
9606
TAXONOMY
Collagen alpha-1(I) chain
SubPathwayActivator
Coagulation factor XIIa
P12259
UniProt
P02452
UniProt
Coagulation factor XIIIa
SubPathwayActivation
1.0
P05160
UniProt
ReactionCatalysis1126
ACTIVATION
ReactionCatalysis1125
ACTIVATION
ReactionCatalysis1129
ACTIVATION
1.0
Coagulation factor V
ReactionCatalysis1124
ACTIVATION
Fibrin degradation products
SMILES
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\C[C@@]12O[C@]1(C)C(=O)C1=C(C=CC=C1)C2=O
Coagulation factor XIII A chain
Coagulation factor XIII A chain
Tissue factor:Coagulation factor VIIa
SubPathwayActivation
Precursors of Prothrombin and coagulation factors VII, IX, ad X
SubPathwayControl216
SubPathway216Control
ActivatingSubPathwayControl
Prothrombin and coagulation factors VII, IX and X
1.0
Coagulation factor XIa
Thrombin
Vitamin K epoxide reductase complex subunit 1
SubPathwayOutput
ReactionCatalysis1134
ACTIVATION
Plasma kallikrein
Tissue-type plasminogen activator
Coagulation factor XIIIa
Tissue factor
SubPathwayActivator
Coagulation factor XIII B chain
Fibrinogen alpha chain
Fibrinogen beta chain
1.0
Thrombin
Phenindione Action Pathway
P00734
UniProt
Coagulation factor XIII A and B activate to Coagulation factor XIIIa
ActivatingSubPathway
SubPathwayInteraction888
SubPathway888Reaction
SubPathwayReaction
Coagulation factor XIIa
SubPathwayActivation
SubPathwayActivator
Vitamin K-dependent gamma-carboxylase
SubPathwayControl235
SubPathway235Control
ActivatingSubPathwayControl
1.0
Plasma kallikrein
SubPathwayActivator
CHEBI:8066
ChEBI
CHEBI:18067
ChEBI
P00747
UniProt
Reduced Vitamin K (phylloquinone)
P00748
UniProt
Coagulation factor XIa
C31H48O2
Reduced Vitamin K (phylloquinone)
452.36542
P00740
UniProt
P00742
UniProt