PI3-K activation of PKB
ActivatingSubPathway
PKB inhibition of TSC
InhibitorySubPathway
CHEBI:15603
ChEBI
P06213
UniProt
P06730
UniProt
1.0
1.0
Insulin receptor substrate 1
1.0
1.0
Reaction2220
true
Insulin receptor substrate 1 with Phosphorylation + Insulin receptor substrate 2 with Phosphorylation + Phosphatidylinositol 4,5-bisphosphate 3-kinase → Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
LEFT_TO_RIGHT
Ribosomal protein S6 kinase beta-1
SubPathwayActivation
2.7.10.1
false
2.7.10.1
Insulin receptor substrate 2 → Insulin receptor substrate 2 with Phosphorylation
LEFT_TO_RIGHT
2.7.10.1
false
2.7.10.1
Insulin receptor substrate 1 → Insulin receptor substrate 1 with Phosphorylation
LEFT_TO_RIGHT
Serine/threonine-protein kinase mTOR
P35568
UniProt
Ribosomal protein S6 kinase beta-1
Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
SubPathwayActivator
Leucine Stimulation on Insulin Signaling
GTP-binding protein Rheb
SubPathwayInhibition
SubPathwayActivation
SubPathwayActivator
RAC-alpha serine/threonine-protein kinase
Q9Y4H2
UniProt
Eukaryotic translation initiation factor 4E
SubPathwayInhibition
TSC inhibition of Rheb
InhibitorySubPathway
Leucine activation of Rheb
ActivatingSubPathway
Rheb activation of mTOR
ActivatingSubPathway
mTOR activation of p70S6K
ActivatingSubPathway
4EBP1 inhibition of eIF4E
InhibitorySubPathway
2.7.11.1
false
2.7.11.1
Eukaryotic translation initiation factor 4E-binding protein → Eukaryotic translation initiation factor 4E-binding protein with Phosphorylation
LEFT_TO_RIGHT
Insulin receptor activation
ActivatingSubPathway
RAC-alpha serine/threonine-protein kinase
SubPathwayInhibitor
SubPathwayActivation
Eukaryotic translation initiation factor 4E-binding protein 1
Eukaryotic translation initiation factor 4E
Hamartin
Tuberin
Homo sapiens
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Insulin receptor substrate 2
Insulin
Eukaryotic translation initiation factor 4E-binding protein 1
SubPathwayInhibitor
GO:0005829
GENE ONTOLOGY
Insulin
Serine/threonine-protein kinase mTOR
SubPathwayActivation
SubPathwayActivator
Insulin receptor
SubPathwayActivation
Q13541
UniProt
1.0
1.0
GTP-binding protein Rheb
Large neutral amino acids transporter small subunit 1
HMDB0000687
HMDB
L-Leucine
TransportCatalysis226
ACTIVATION
C6H13NO2
L-Leucine
131.09464
9606
TAXONOMY
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
1.0
Tuberin
61-90-5
CAS
Cytosol
Insulin receptor substrate 2
6106
PubChem-compound
Q92574
UniProt
Phosphoinositide 3-kinase regulatory subunit 6
Insulin receptor substrate 1
5880
ChemSpider
P48736
UniProt
PW000659
PathWhiz
GO:0005886
GENE ONTOLOGY
SMP0000682
SMPDB
Transport278
false
L-Leucine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
1.0
Cell Membrane
Q15382
UniProt
LEU
BioCyc
C00123
KEGG Compound
Phosphoinositide 3-kinase regulatory subunit 6
SMILES
CC(C)C[C@H](N)C(O)=O
L-Leucine
SubPathwayActivator
Insulin receptor
Insulin
SubPathwayActivator
Hamartin
SubPathwayControl880
SubPathway880Control
InhibitorySubPathwayControl
Insulin receptor substrate 1
SubPathwayControl881
SubPathway881Control
ActivatingSubPathwayControl
2.0
SubPathwayControl882
SubPathway882Control
ActivatingSubPathwayControl
SubPathwayControl883
SubPathway883Control
ActivatingSubPathwayControl
SubPathwayControl884
SubPathway884Control
InhibitorySubPathwayControl
SubPathwayControl885
SubPathway885Control
ActivatingSubPathwayControl
Insulin receptor
Tuberous sclerosis complex
SubPathwayInhibition
SubPathwayInhibitor
1.0
Extracellular Space
ReactionCatalysis2236
ACTIVATION
P01308
UniProt
Large neutral amino acids transporter small subunit 1
1.0
ReactionCatalysis2082
ACTIVATION
ReactionCatalysis2083
ACTIVATION
Phosphatidylinositol 4,5-bisphosphate 3-kinase
Q5UE93
UniProt
SubPathwayControl878
SubPathway878Control
ActivatingSubPathwayControl
SubPathwayControl879
SubPathway879Control
InhibitorySubPathwayControl
P31749
UniProt
P49815
UniProt
1.0
Q01650
UniProt
GO:0005615
GENE ONTOLOGY
P42345
UniProt
P23443
UniProt
1.0