Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Leukotriene-
B(4) omega-
hydroxylase 1
Leukotriene A-4
hydrolase
Leukotriene C4
synthase
Gamma-
glutamyltranspeptidase
1
Glutathione
peroxidase 1
Prostacyclin
synthase
Prostaglandin-
H2 D-isomerase
Aldo-keto
reductase
family 1 member
C3
Thromboxane-A
synthase
Prostaglandin E
synthase
Prostamide/prostaglandin
F synthase
Carbonyl
reductase
[NADPH] 1
Arachidonate
15-lipoxygenase
Cytochrome P450
2C8
Cytochrome P450
2C8
Cytochrome P450
2C8
Cytochrome P450
2C8
Cytochrome P450
2C8
Cytochrome P450
2B6
Epoxide
hydratase 2
Cytochrome P450
2B6
Epoxide
hydratase 2
Arachidonate
5-lipoxygenase
Arachidonate
5-lipoxygenase
Glutathione
peroxidase 1
Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Cytochrome P450
2B6
Epoxide
hydratase 2
Cytochrome P450
2B6
Epoxide
hydratase 2
Arachidonate
15-lipoxygenase
B
Cytochrome P450
2E1
Arachidonate
12-
lipoxygenase,
12R-type
Cytochrome P450
2J2
Cytochrome P450
2U1
Cytochrome P450
4A11
Cytochrome P450
2U1
Arachidonate
12-
lipoxygenase,
12S-type
Cytosolic
phospholipase
A2 beta
Cytochrome P450
4F8
Leukotriene-
B(4) omega-
hydroxylase 2
Nepafenac
Heme
Heme
20-Hydroxy-leukotriene B4
20-Carboxy-leukotriene B4
Leukotriene B4
NADPH
O2
NADP
H2O
Leukotriene A4
H2O
12-Keto-leukotriene B4
Glutathione
Leukotriene C4
H2O
Leukotriene D4
L-Glutamic acid
5,6-Epoxytetraene
15(S)-HPETE
Glutathione
15(S)-HETE
Oxidized glutathione
H2O
δ-12-Prostaglandin J2
15-Deoxy-d-12,14-PGJ2
6-Keto-prostaglandin F1a
6-Ketoprostaglandin E1
5-HETE
5-KETE
Prostaglandin J2
Prostaglandin I2
Prostaglandin D2
Prostaglandin H2
NADPH
11-Epi-PGF2a
NADP
Thromboxane A2
Prostaglandin E2
Prostaglandin F2a
NADPH
NADP
Prostaglandin A2
Prostaglandin-c2
Thromboxane B2
Prostaglandin B2
11-Dehydro-thromboxane B2
Arachidonic acid
O2
O2
11H-14,15-EETA
H2O
O2
11,14,15-THETA
H2O
O2
15H-11,12-EETA
H2O
O2
11,12,15-THETA
H2O
O2
16(R)-HETE
H2O
O2
14,15-Epoxy-5,8,11-
eicosatrienoic acid
H2O
H2O
14,15-DiHETrE
O2
11,12-Epoxyeicosatrienoic acid
H2O
H2O
11,12-DiHETrE
5-HPETE
O2
H2O
O2
H2O
Glutathione
Oxidized glutathione
H2O
Prostaglandin G2
H2O
O2
O2
8,9-Epoxyeicosatrienoic acid
H2O
H2O
8,9-DiHETrE
O2
5,6-Epoxy-8,11,14-
eicosatrienoic acid
H2O
H2O
5,6-DHET
O2
8(S)-HPETE
O2
19(S)-HETE
H2O
O2
12(R)-HPETE
8-HETE
Arachidonic acid
8-Isoprostane
O2
H2O
O2
H2O
O2
20-Hydroxyeicosatetraenoic
acid
H2O
O2
H2O
O2
12(S)-HPETE
12(R)-HETE
12-KETE
12(S)-HETE
PC(14:0/20:4(5Z,8Z,11Z,14Z))
H2O
LysoPC(14:0/0:0)
NADPH
O2
NADP
H2O
2,3-Dinor-8iso prostaglandin
F1α
2,3-Dinor-8iso prostaglandin
F2α
Zinc (II) ion
Heme
Glutathione
Fe3+
Fe3+
Calcium
Heme
Heme
Heme
Heme
Heme
Fe3+
Heme
Fe3+
Heme
Fe3+
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Magnesium
Heme
Magnesium
Calcium
Heme
Magnesium
Magnesium
Heme
Heme
Heme
Calcium
Heme
Heme
Heme
Fe3+
Cytosol
Lumen
Lumen
Cytosol
Lumen
Cytosol
Lumen
Cytosol
Lumen
Smooth Endoplasmic Reticulum
Extracellular Space
Intracellular Space