CHEBI:16015
ChEBI
79551-86-3
CAS
C20H32O2
Arachidonic acid
304.24023
3.0
20559-16-4
CAS
SMILES
CN1\C(=C(/O)NC2=CC=CC=N2)C(=O)C2=C(C=CS2)S1(=O)=O
1.0
HMDB0061118
HMDB
HMDB0061119
HMDB
1.0
HMDB0061377
HMDB
C04805
KEGG Compound
14,15-Epoxy-5,8,11-eicosatrienoic acid
24778634
PubChem-compound
NADPH
1.0
Leukotriene B4
C22H46NO7P
LysoPC(14:0/0:0)
467.30118
Cytochrome P450 4A11
Leukotriene A4
HMDB0003252
HMDB
5,6-Epoxy-8,11,14-eicosatrienoic acid
P07203
UniProt
1.0
BTO:0000759
BRENDA TISSUE ONTOLOGY
1.0
C00219
KEGG Compound
1.0
60203-57-8
CAS
C00696
KEGG Compound
59804-37-4
CAS
CHEBI:16474
ChEBI
Q8TBF2
UniProt
SMILES
CCCCC\C=C/C[C@@H](OO)\C=C\C=C/C\C=C/CCCC(O)=O
SMILES
CCCCC\C=C/C\C=C/C\C=C/C=C/C(CCCC(O)=O)OO
SMILES
CCCCC\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O
SMILES
CCCCC[C@H](O)\C=C\[C@H]1[C@@H](O)CC(O)C1C\C=C/CCCC(O)=O
SMILES
C[C@H](O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
SMILES
CCCCC\C=C/C\C=C/C=C/[C@@H](O)C\C=C/CCCC(O)=O
SMILES
CCCC[C@@H](O)\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
HMDB0001085
HMDB
SMILES
CCCCC[C@H](O)\C=C\C(O)C(O)C\C=C/C\C=C/CCCC(O)=O
SMILES
[H][C@](O)(CCCCC)\C=C\[C@@]1([H])C(=O)C[C@]([H])(O)[C@]1([H])C\C=C/CCCC(O)=O
P16152
UniProt
SMILES
CCCCC\C=C/C[C@H]1O[C@H]1C\C=C/C\C=C/CCCC(O)=O
HMDB0061111
HMDB
C01312
KEGG Compound
SMILES
CCCCC\C=C/C\C=C/C=C/[C@H](C\C=C/CCCC(O)=O)OO
SMILES
CCCCCC1OC1\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O
77667-09-5
CAS
1.0
SMILES
CCCCCC(O)C(O)\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O
58962-34-8
CAS
6-Ketoprostaglandin E1
5283154
PubChem-compound
5283155
PubChem-compound
HMDB0002190
HMDB
5283156
PubChem-compound
124886
PubChem-compound
L-Glutamic acid
2.0
P51589
UniProt
5283157
PubChem-compound
5283159
PubChem-compound
1.0
1.0
HMDB0007883
HMDB
9548884
PubChem-compound
9548883
PubChem-compound
C00007
KEGG Compound
C00006
KEGG Compound
9548885
PubChem-compound
5283142
PubChem-compound
1.0
CHEBI:18009
ChEBI
5283144
PubChem-compound
C00001
KEGG Compound
NADP
C00005
KEGG Compound
9548880
PubChem-compound
1.0
C20H34O6
6-Keto-prostaglandin F1a
370.23553
NADP
Aldo-keto reductase family 1 member C3
5283146
PubChem-compound
5283147
PubChem-compound
5283171
PubChem-compound
11954058
PubChem-compound
ReactionCatalysis2192
ACTIVATION
11954059
PubChem-compound
C05949
KEGG Compound
C04853
KEGG Compound
17395793
PubChem-compound
CHEBI:28269
ChEBI
17395792
PubChem-compound
Cytochrome P450 2E1
1.0
1.0
1.0
SMILES
CCCCC[C@H](O)\C=C\C1=CCC(=O)[C@@H]1C\C=C/CCCC(O)=O
SMILES
CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O
HMDB0061378
HMDB
11954060
PubChem-compound
SMILES
CCCCC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/CCCC(O)=O
5283162
PubChem-compound
SMILES
CCCCC\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O
C05958
KEGG Compound
C20H32O4
Leukotriene B4
336.23007
C05957
KEGG Compound
2.0
C05959
KEGG Compound
C05954
KEGG Compound
C05953
KEGG Compound
C05956
KEGG Compound
C05955
KEGG Compound
C05950
KEGG Compound
C00025
KEGG Compound
C05951
KEGG Compound
12-KETE
1.0
SMILES
CCCCC\C=C/CC(=O)\C=C\C=C/C\C=C/CCCC(O)=O
1.0
1.0
ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
BioCyc
Arachidonic acid
Cytosolic phospholipase A2 beta
15(S)-HPETE
87893-54-7
CAS
C20H32O3
8,9-Epoxyeicosatrienoic acid
320.23514
C05965
KEGG Compound
C05964
KEGG Compound
O75342
UniProt
C05966
KEGG Compound
C42H76NO8P
PC(14:0/20:4(5Z,8Z,11Z,14Z))
753.5309
SMILES
CCCCC[C@H](OO)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O
C05961
KEGG Compound
C05963
KEGG Compound
C05962
KEGG Compound
SMILES
CCCCCC1OC1C\C=C/C\C=C/C\C=C/CCCC(O)=O
HMDB0002314
HMDB
PC(14:0/20:4(5Z,8Z,11Z,14Z))
HMDB0002311
HMDB
Prostamide/prostaglandin F synthase
HMDB0001220
HMDB
1.0
Leukotriene C4 synthase
SMILES
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC(C[C@H]12)=CCCCC(O)=O
1.0
C20H32O3
20-Hydroxyeicosatetraenoic acid
320.23514
460604
PubChem-compound
C20H34O4
14,15-DiHETrE
338.2457
Reaction2296
false
Arachidonic acid + NADPH + Oxygen → 20-Hydroxyeicosatetraenoic acid + NADP + Water
LEFT_TO_RIGHT
1.0
C00051
KEGG Compound
HMDB0000148
HMDB
1.0
SMILES
CCCCC\C=C/C\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O
C20H34O5
Prostaglandin F2a
354.24063
67675-13-2
CAS
SMP0000706
SMPDB
1.0
Prostaglandin F2a
Leukotriene A4
12-Keto-leukotriene B4
Prostacyclin synthase
1.0
5283137
PubChem-compound
BiologicalState10
Homo sapiens, Liver
1.0
C20H32O3
15(S)-HETE
320.23514
1.0
Prostaglandin E2
SMILES
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CC(=O)CCCCC(O)=O
SMILES
CCCCC[C@H](O)\C=C\[C@H]1OC(=O)C[C@H](O)[C@@H]1C\C=C\CCCC(O)=O
SMILES
CCCCC\C=C/C[C@H](OO)\C=C\C=C/C\C=C/CCCC(O)=O
1.0
SMILES
CCCCC[C@H](O)C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O
8-Isoprostane
HMDB0002343
HMDB
Oxidized glutathione
P20813
UniProt
962
PubChem-compound
11-Epi-PGF2a
1.0
C20H30O6
20-Carboxy-leukotriene B4
366.20422
SMILES
O=O
C20H34O4
8,9-DiHETrE
338.2457
C20H34O4
11,12-DiHETrE
338.2457
Prostaglandin I2
SMILES
CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O
SMILES
CCCCC[C@H](O)\C=C\[C@H]1[C@H]2C[C@H](OO2)[C@@H]1C\C=C/CCCC(O)=O
HMDB0002111
HMDB
5,6-Epoxy-8,11,14-eicosatrienoic acid
81246-85-7
CAS
4471584
ChemSpider
Leukotriene C4 synthase
CHEBI:34306
ChEBI
SMILES
[H][C@@]1(CCCCCCC)CCC[C@]1([H])CCCCCCCC
Arachidonate 15-lipoxygenase
C25H40N2O6S
Leukotriene D4
496.2607
20-Hydroxy-leukotriene B4
HMDB0001043
HMDB
506-32-1
CAS
Prostaglandin G2
977
PubChem-compound
1.0
C04230
KEGG Compound
SMILES
CCCCC[C@H](O)\C=C\C1OC1C\C=C/C\C=C/CCCC(O)=O
HMDB0003235
HMDB
Glutathione peroxidase 1
1.0
CHEBI:28099
ChEBI
73836-78-9
CAS
4444399
ChemSpider
30572
ChemSpider
17215925
ChemSpider
PROSTAGLANDIN-H2
BioCyc
Cytochrome P450 2U1
Thromboxane A2
CHEBI:34487
ChEBI
Cytochrome P450 2E1
6-Keto-prostaglandin F1a
CHEBI:34486
ChEBI
11,12-Epoxyeicosatrienoic acid
19(S)-HETE
HMDB0002710
HMDB
Cytochrome P450 4F8
C20H32O5
Thromboxane A2
352.22498
Prostaglandin G/H synthase 1
4446324
ChemSpider
4446326
ChemSpider
74581-83-2
CAS
4446323
ChemSpider
Cytochrome P450 2B6
CHEBI:34230
ChEBI
LysoPC(14:0/0:0)
SMILES
O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C\C=C/CCCCC(O)=O
Water
5282411
PubChem-compound
CHEBI:34229
ChEBI
4444133
ChemSpider
4444132
ChemSpider
4444137
ChemSpider
1.0
Cytochrome P450 4F8
C20H34O4
5,6-DHET
338.2457
Cytochrome P450 2J2
SMILES
CCCCCCCCCCCCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC
Cytochrome P450 2C8
HMDB0001403
HMDB
1.0
5.3.99.5
false
5.3.99.5
Prostaglandin H2 → Thromboxane A2
LEFT_TO_RIGHT
P35354
UniProt
20-Hydroxy-leukotriene B4
Leukotriene C4
Cytochrome P450 4A11
1.0
5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY
BioCyc
8(S)-HPETE
HMDB0013633
HMDB
5280493
PubChem-compound
Prostaglandin-H2 D-isomerase
551-11-1
CAS
5280492
PubChem-compound
SMILES
CCCCCC(O)C(O)C\C=C/C\C=C/C\C=C/CCCC(O)=O
CHEBI:34450
ChEBI
CPD-8892
BioCyc
SMILES
OCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
2,3-Dinor-8iso prostaglandin F1α
SMILES
CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
5280497
PubChem-compound
1.0
1.0
C00909
KEGG Compound
Tenoxicam inhibition of Prostaglandin G/H synthase 2
InhibitorySubPathway
Tenoxicam inhibition of Prostaglandin G/H synthase 1
InhibitorySubPathway
NADPH
BioCyc
Leukotriene A4
CHEBI:16856
ChEBI
CHEBI:64095
ChEBI
SMILES
CCCCC\C=C/C\C=C/C\C=C/CC(O)C(O)CCCC(O)=O
HMDB0010379
HMDB
CPD-6641
BioCyc
Bifunctional epoxide hydrolase 2
Thromboxane-A synthase
C20H32O5
20-Hydroxy-leukotriene B4
352.22498
CHEBI:553047
ChEBI
HMDB0002752
HMDB
42935-17-1
CAS
1.0
1.0
Prostaglandin G/H synthase 2
Prostaglandin-c2
16(R)-HETE
NADPH
Liver
C10H17N3O6S
Glutathione
307.0838
11-Dehydro-thromboxane B2
97008
ChemSpider
CHEBI:607727
ChEBI
2.0
Cytochrome P450 2U1
448457
PubChem-compound
Leukotriene A-4 hydrolase
C18H30O5
2,3-Dinor-8iso prostaglandin F2α
326.20932
SMILES
CCCCC\C=C/CC(O)C(O)C\C=C/C\C=C/CCCC(O)=O
C18H32O5
2,3-Dinor-8iso prostaglandin F1α
328.22498
SMILES
CCCCC\C=C/C\C=C/CC(O)C(O)C\C=C/CCCC(O)=O
1.0
Aldo-keto reductase family 1 member C3
Thromboxane A2
1.0
1.0
1.0
CHEBI:34490
ChEBI
1.0
1.0
79516-82-8
CAS
HMDB0003876
HMDB
HMDB0000125
HMDB
Arachidonic acid
GO:0005737
GENE ONTOLOGY
15(S)-HPETE
4510033
ChemSpider
HMDB0001452
HMDB
70-18-8
CAS
4444314
ChemSpider
1.0
1.0
81276-03-1
CAS
5280884
PubChem-compound
CHEBI:27555
ChEBI
14,15-DiHETrE
5280885
PubChem-compound
5280882
PubChem-compound
5280883
PubChem-compound
5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
BioCyc
5280880
PubChem-compound
1.0
392692
ChemSpider
1.14.99.1
false
1.14.99.1
Prostaglandin G2 → Prostaglandin H2 + Water
LEFT_TO_RIGHT
5280888
PubChem-compound
5280889
PubChem-compound
11954043
PubChem-compound
Prostaglandin E synthase
11954042
PubChem-compound
Glutathione peroxidase 1
Carbonyl reductase [NADPH] 1
1.0
SMILES
CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C\[C@@H](O)CCCC(O)=O
5675
ChemSpider
5280876
PubChem-compound
Water
12(R)-HPETE
5280877
PubChem-compound
Prostaglandin G/H synthase 1
5280878
PubChem-compound
4444307
ChemSpider
PW000683
PathWhiz
Thromboxane-A synthase
5288144
PubChem-compound
70981-96-3
CAS
SMILES
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
C13809
KEGG Compound
Cytosolic phospholipase A2 beta
8,9-DiHETrE
1.0
GO:0005789
GENE ONTOLOGY
Prostaglandin G/H synthase 1
SubPathwayInhibition
15(S)-HPETE
Reaction377
false
Arachidonic acid + Oxygen → 12(S)-HPETE
LEFT_TO_RIGHT
Reaction378
false
Arachidonic acid + Oxygen → 15(S)-HPETE
LEFT_TO_RIGHT
GO:0005783
GENE ONTOLOGY
3.3.2.6
false
3.3.2.6
Leukotriene A4 + Water → Leukotriene B4
LEFT_TO_RIGHT
C5H9NO4
L-Glutamic acid
147.05316
33032
PubChem-compound
CHEBI:15553
ChEBI
CHEBI:15552
ChEBI
CHEBI:15555
ChEBI
CHEBI:15554
ChEBI
1.0
CHEBI:15558
ChEBI
Prostacyclin synthase
CHEBI:15551
ChEBI
7782-44-7
CAS
5280893
PubChem-compound
5-HETE
SMILES
CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C
5280892
PubChem-compound
4.4.1.20
false
4.4.1.20
Glutathione + Leukotriene A4 → Leukotriene C4
LEFT_TO_RIGHT
Reaction385
false
Arachidonic acid + Oxygen → 8(S)-HPETE
LEFT_TO_RIGHT
9606
TAXONOMY
ReactionCatalysis476
ACTIVATION
ReactionCatalysis477
ACTIVATION
ReactionCatalysis474
ACTIVATION
P10632
UniProt
ReactionCatalysis475
ACTIVATION
ReactionCatalysis473
ACTIVATION
ReactionCatalysis470
ACTIVATION
ReactionCatalysis471
ACTIVATION
1.0
192461-96-4
CAS
SMILES
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C\CCCC(O)=O
C20H30O4
12-Keto-leukotriene B4
334.21442
C20H30O4
Prostaglandin B2
334.21442
CHEBI:28209
ChEBI
51982-36-6
CAS
ReactionCatalysis469
ACTIVATION
P19440
UniProt
CHEBI:27595
ChEBI
ReactionCatalysis467
ACTIVATION
ReactionCatalysis468
ACTIVATION
CHEBI:15377
ChEBI
ReactionCatalysis465
ACTIVATION
ReactionCatalysis466
ACTIVATION
CHEBI:15379
ChEBI
ReactionCatalysis463
ACTIVATION
70608-72-9
CAS
ReactionCatalysis464
ACTIVATION
ReactionCatalysis461
ACTIVATION
ReactionCatalysis462
ACTIVATION
Reaction326
false
8,9-Epoxyeicosatrienoic acid + Water → 8,9-DiHETrE
LEFT_TO_RIGHT
Reaction327
false
5,6-Epoxy-8,11,14-eicosatrienoic acid + Water → 5,6-DHET
LEFT_TO_RIGHT
Epoxide hydratase 2
SMILES
CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O
SMILES
CCCCC\C=C/C\C=C/CC1OC1C\C=C/CCCC(O)=O
C20H30O3
5-KETE
318.21948
C05356
KEGG Compound
Reaction325
false
14,15-Epoxy-5,8,11-eicosatrienoic acid + Water → 14,15-DiHETrE
LEFT_TO_RIGHT
111188
ChemSpider
ReactionCatalysis498
ACTIVATION
80434-82-8
CAS
ReactionCatalysis496
ACTIVATION
30776537
ChemSpider
ReactionCatalysis497
ACTIVATION
72025-60-6
CAS
ReactionCatalysis494
ACTIVATION
27025-41-8
CAS
ReactionCatalysis495
ACTIVATION
ReactionCatalysis492
ACTIVATION
ReactionCatalysis493
ACTIVATION
ReactionCatalysis490
ACTIVATION
1.0
ReactionCatalysis491
ACTIVATION
1.0
1.0
CHEBI:28666
ChEBI
CHEBI:28667
ChEBI
HMDB0006059
HMDB
ReactionCatalysis489
ACTIVATION
ReactionCatalysis487
ACTIVATION
ReactionCatalysis485
ACTIVATION
ReactionCatalysis486
ACTIVATION
ReactionCatalysis484
ACTIVATION
4444320
ChemSpider
ReactionCatalysis481
ACTIVATION
ReactionCatalysis482
ACTIVATION
ReactionCatalysis480
ACTIVATION
SMILES
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC(=O)CCCCC(O)=O
Prostaglandin G/H synthase 1
CHEBI:27562
ChEBI
ReactionCatalysis478
ACTIVATION
ReactionCatalysis479
ACTIVATION
57576-52-0
CAS
Tenoxicam Action Pathway
P09960
UniProt
5283078
PubChem-compound
937
ChemSpider
53477781
PubChem-compound
C20H32O5
Prostaglandin E2
352.22498
12(S)-HPETE
P41222
UniProt
HMDB0004699
HMDB
C14717
KEGG Compound
P0C869
UniProt
HMDB0004693
HMDB
HMDB0004692
HMDB
5353269
PubChem-compound
HMDB0004694
HMDB
3.0
1.0
Q02928
UniProt
71160-24-2
CAS
P34913
UniProt
Prostaglandin G/H synthase 2
SubPathwayInhibition
1.0
1.0
HMDB0001198
HMDB
Q7Z449
UniProt
67910-12-7
CAS
1.0
1.0
Prostaglandin D2
192461-95-3
CAS
952
ChemSpider
HMDB0004238
HMDB
950
ChemSpider
4450370
ChemSpider
HMDB0004236
HMDB
HMDB0004234
HMDB
C14732
KEGG Compound
Leukotriene-B(4) omega-hydroxylase 1
Leukotriene D4
C30H47N3O9S
Leukotriene C4
625.3033
11,14,15-THETA
C00584
KEGG Compound
1.0
Q08477
UniProt
O14684
UniProt
363-24-6
CAS
C14749
KEGG Compound
C14748
KEGG Compound
1.0
11H-14,15-EETA
HMDB0004242
HMDB
HMDB0004241
HMDB
1.0
HMDB0004244
HMDB
CHEBI:27485
ChEBI
1.0
HMDB0004243
HMDB
1.0
Cytosol
1.0
PHOSPHATIDYLCHOLINE
BioCyc
C00127
KEGG Compound
C14770
KEGG Compound
136696-10-1
CAS
11,12-DiHETrE
1.0
C20H32N6O12S2
Oxidized glutathione
612.152
SMILES
CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
CHEBI:28158
ChEBI
C14769
KEGG Compound
C14768
KEGG Compound
HMDB0004264
HMDB
ReactionCatalysis738
ACTIVATION
Oxygen
79551-85-2
CAS
C14781
KEGG Compound
Gamma-glutamyltranspeptidase 1
5-HPETE
11,12,15-THETA
444899
PubChem-compound
C20H32O6
Prostaglandin G2
368.21988
NAD(P)
BioCyc
SMILES
CCCCC\C=C/CC(=O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
SMILES
CCCCC[C@@H](O)\C=C\C1=C(C\C=C/CCCC(O)=O)C(=O)CC1
CHEBI:52449
ChEBI
Cytochrome P450 2J2
C14774
KEGG Compound
C14773
KEGG Compound
C14772
KEGG Compound
C14771
KEGG Compound
1.0
C14778
KEGG Compound
21467087
ChemSpider
C14777
KEGG Compound
C14776
KEGG Compound
C14775
KEGG Compound
P98187
UniProt
392800
ChemSpider
C20H34O6
Thromboxane B2
370.23553
C04742
KEGG Compound
SMILES
CCCCC\C=C/C\C=C/C\C=C/C=C/C(=O)CCCC(O)=O
CHEBI:28130
ChEBI
C14782
KEGG Compound
Reaction915
true
12(S)-HPETE → 12(S)-HETE
LEFT_TO_RIGHT
3.1.1.4
false
3.1.1.4
PC(14:0/20:4(5Z,8Z,11Z,14Z)) + Water ↔ Arachidonic acid + LysoPC(14:0/0:0)
REVERSIBLE
1.14.15.3
false
1.14.15.3
Arachidonic acid + Oxygen → 20-Hydroxyeicosatetraenoic acid + Water
LEFT_TO_RIGHT
Reaction914
true
12(S)-HPETE → 12-KETE
LEFT_TO_RIGHT
OXIDIZED-GLUTATHIONE
BioCyc
Reaction911
true
8-Isoprostane → 2,3-Dinor-8iso prostaglandin F1α
LEFT_TO_RIGHT
1.0
Reaction912
true
8-Isoprostane → 2,3-Dinor-8iso prostaglandin F2α
LEFT_TO_RIGHT
Reaction910
true
Arachidonic acid → 8-Isoprostane
LEFT_TO_RIGHT
4446295
ChemSpider
C00157
KEGG Compound
67786-53-2
CAS
4446283
ChemSpider
4446286
ChemSpider
4446280
ChemSpider
Tenoxicam
SubPathwayInhibitor
4446281
ChemSpider
5311211
PubChem-compound
4.0
Bifunctional epoxide hydrolase 2
87893-55-8
CAS
4446278
ChemSpider
4446279
ChemSpider
1.0
7732-18-5
CAS
13367-85-6
CAS
4446270
ChemSpider
126432-17-5
CAS
4446271
ChemSpider
Water
SMILES
CCCCC[C@H](O)\C=C\[C@H]1O[C@H]2C[C@H](O2)[C@@H]1C\C=C/CCCC(O)=O
56-86-0
CAS
Prostaglandin B2
Prostaglandin D2
4446266
ChemSpider
4446268
ChemSpider
4446261
ChemSpider
1.0
HMDB0001377
HMDB
Gamma-glutamyltranspeptidase 1
5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
BioCyc
HMDB0001139
HMDB
Prostaglandin H2
P09917
UniProt
Leukotriene B4
8-HETE
1.0
12(R)-HETE
SMILES
CCCCCC(O)\C=C\[C@H]1C(O)CC(O)[C@H]1CCCCC(O)=O
SMILES
CCCCCC(O)\C=C\[C@H]1C(O)CC(O)[C@H]1C\C=C/CC(O)=O
20-Hydroxyeicosatetraenoic acid
HMDB0004659
HMDB
5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
BioCyc
HMDB0001381
HMDB
SMILES
N[C@@H](CCC(O)=O)C(O)=O
Glutathione
HMDB0002232
HMDB
8,9-Epoxyeicosatrienoic acid
CHEBI:64489
ChEBI
12(S)-HETE
7827808
ChemSpider
7827807
ChemSpider
7827806
ChemSpider
C20H30O4
Prostaglandin J2
334.21442
HMDB0003337
HMDB
HMDB0005998
HMDB
395250
ChemSpider
2.0
7827803
ChemSpider
54845-95-3
CAS
20-Hydroxyeicosatetraenoic acid
Prostaglandin I2
Leukotriene C4 synthase
HMDB0004679
HMDB
22833512
PubChem-compound
81246-84-6
CAS
H2O
Water
18.010565
SMILES
OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
35121-78-9
CAS
HMDB0004673
HMDB
1.14.13.-
false
1.14.13.-
Arachidonic acid + Oxygen → 5,6-Epoxy-8,11,14-eicosatrienoic acid + Water
LEFT_TO_RIGHT
1.11.1.9
false
1.11.1.9
5-HPETE + 2 Glutathione → 5-HETE + Oxidized glutathione + Water
LEFT_TO_RIGHT
1.14.13.-
false
1.14.13.-
Arachidonic acid + Oxygen → 8,9-Epoxyeicosatrienoic acid + Water
LEFT_TO_RIGHT
1.13.11.34
false
1.13.11.34
5-HPETE + Oxygen → Leukotriene A4 + Water
LEFT_TO_RIGHT
Glutathione
1.13.11.34
false
1.13.11.34
Arachidonic acid + Oxygen → 5-HPETE + Water
LEFT_TO_RIGHT
219535-29-2
CAS
12(R)-HPETE
1.0
8,9-Epoxyeicosatrienoic acid
C02165
KEGG Compound
5,6-DHET
Reaction908
true
8(S)-HPETE → 8-HETE
LEFT_TO_RIGHT
C02166
KEGG Compound
Reaction909
true
12(R)-HPETE → 12(R)-HETE
LEFT_TO_RIGHT
Reaction906
false
Arachidonic acid + Oxygen → 19(S)-HETE + Water
LEFT_TO_RIGHT
1.13.11.-
false
1.13.11.-
Arachidonic acid + Oxygen → 12(R)-HPETE
LEFT_TO_RIGHT
1.0
ARACHIDONIC_ACID
BioCyc
SMILES
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
5283202
PubChem-compound
HMDB0004680
HMDB
5283203
PubChem-compound
5283205
PubChem-compound
HMDB0002265
HMDB
HMDB0004684
HMDB
Reaction878
true
δ-12-Prostaglandin J2 → 15-Deoxy-d-12,14-PGJ2
LEFT_TO_RIGHT
CHEBI:15843
ChEBI
Reaction879
true
6-Keto-prostaglandin F1a → 6-Ketoprostaglandin E1
LEFT_TO_RIGHT
Reaction876
true
15(S)-HPETE → 5,6-Epoxytetraene
LEFT_TO_RIGHT
1.11.1.9
false
1.11.1.9
15(S)-HPETE + 2 Glutathione → 15(S)-HETE + Oxidized glutathione + Water
LEFT_TO_RIGHT
6Z8E10E14Z-5S12R-512-DIHYDROXYI
BioCyc
445049
PubChem-compound
5280360
PubChem-compound
155976-51-5
CAS
SMILES
O
72059-45-1
CAS
Reaction874
false
Leukotriene C4 + Water → L-Glutamic acid + Leukotriene D4
LEFT_TO_RIGHT
Reaction875
true
5,6-Epoxytetraene → Leukotriene A4
LEFT_TO_RIGHT
Reaction872
false
Leukotriene B4 + NADPH + Oxygen → 20-Hydroxy-leukotriene B4 + NADP + Water
LEFT_TO_RIGHT
Reaction873
true
Leukotriene B4 → 12-Keto-leukotriene B4
LEFT_TO_RIGHT
Reaction871
true
20-Hydroxy-leukotriene B4 → 20-Carboxy-leukotriene B4
LEFT_TO_RIGHT
4446204
ChemSpider
Reaction889
true
Prostaglandin-c2 → Prostaglandin B2
LEFT_TO_RIGHT
Reaction887
true
Prostaglandin A2 → Prostaglandin-c2
LEFT_TO_RIGHT
LEUKOTRIENE-C4
BioCyc
Reaction888
true
Thromboxane A2 → Thromboxane B2
LEFT_TO_RIGHT
CHEBI:27814
ChEBI
Leukotriene-B(4) omega-hydroxylase 2
HMDB0001509
HMDB
Leukotriene-B(4) omega-hydroxylase 1
20-Carboxy-leukotriene B4
Leukotriene A-4 hydrolase
CHEBI:33023
ChEBI
C20H30O4
δ-12-Prostaglandin J2
334.21442
CHEBI:27820
ChEBI
15-Deoxy-d-12,14-PGJ2
P24557
UniProt
C20H32O6
6-Ketoprostaglandin E1
368.21988
HMDB0010217
HMDB
1.0
C20H32O6
11-Dehydro-thromboxane B2
368.21988
Reaction885
false
NADPH + Prostaglandin E2 → NADP + Prostaglandin F2a
LEFT_TO_RIGHT
Reaction886
true
Prostaglandin E2 → Prostaglandin A2
LEFT_TO_RIGHT
Reaction883
true
Prostaglandin D2 → Prostaglandin J2
LEFT_TO_RIGHT
Reaction884
false
NADPH + Prostaglandin D2 → 11-Epi-PGF2a + NADP
LEFT_TO_RIGHT
Reaction881
true
Prostaglandin J2 → δ-12-Prostaglandin J2
LEFT_TO_RIGHT
Reaction882
true
Prostaglandin I2 → 6-Keto-prostaglandin F1a
LEFT_TO_RIGHT
877878-78-9
CAS
Reaction880
true
5-HETE → 5-KETE
LEFT_TO_RIGHT
53-59-8
CAS
1.14.13.-
false
1.14.13.-
Arachidonic acid + Oxygen → 11,12-Epoxyeicosatrienoic acid + Water
LEFT_TO_RIGHT
Arachidonic acid
Reaction899
false
11,12-Epoxyeicosatrienoic acid + Water → 11,12-DiHETrE
LEFT_TO_RIGHT
108437-64-5
CAS
5280383
PubChem-compound
C20H30O4
Prostaglandin A2
334.21442
1.0
1.0
C02198
KEGG Compound
1.0
1.0
GO:0005829
GENE ONTOLOGY
1.0
1.14.14.1
false
1.14.14.1
Arachidonic acid + Oxygen → 16(R)-HETE + Water
LEFT_TO_RIGHT
1.14.13.-
false
1.14.13.-
Arachidonic acid + Oxygen → 14,15-Epoxy-5,8,11-eicosatrienoic acid + Water
LEFT_TO_RIGHT
1.14.14.1
false
1.14.14.1
15H-11,12-EETA + Oxygen → 11,12,15-THETA + Water
LEFT_TO_RIGHT
1.14.14.1
false
1.14.14.1
11H-14,15-EETA + Oxygen → 11,14,15-THETA + Water
LEFT_TO_RIGHT
1.14.14.1
false
1.14.14.1
15(S)-HPETE + Oxygen → 15H-11,12-EETA + Water
LEFT_TO_RIGHT
Reaction890
true
Thromboxane B2 → 11-Dehydro-thromboxane B2
LEFT_TO_RIGHT
Q16647
UniProt
1.14.14.1
false
1.14.14.1
15(S)-HPETE + Oxygen → 11H-14,15-EETA + Water
LEFT_TO_RIGHT
Carbonyl reductase [NADPH] 1
11,12-Epoxyeicosatrienoic acid
Prostamide/prostaglandin F synthase
SubPathwayControl954
InhibitorySubPathwayControl
SubPathway954Control
1.0
SubPathwayControl955
InhibitorySubPathwayControl
SubPathway955Control
1.0
2.0
54397-83-0
CAS
C20H32O3
5,6-Epoxy-8,11,14-eicosatrienoic acid
320.23514
C21H30N7O17P3
NADPH
745.0911
C21H28N7O17P3
NADP
743.07544
1.0
HMDB0014612
HMDB
CHEBI:34162
ChEBI
CHEBI:15647
ChEBI
CHEBI:16978
ChEBI
24766559
ChemSpider
CHEBI:15646
ChEBI
5-KETE
ReactionCatalysis191
ACTIVATION
ReactionCatalysis192
ACTIVATION
SMILES
CCCCC[C@H](O)\C=C\[C@H]1C=CC(=O)[C@@H]1C\C=C/CCCC(O)=O
4444074
ChemSpider
1.0
Prostaglandin J2
Prostaglandin E2
HMDB0000217
HMDB
1.0
Prostaglandin A2
213382-49-1
CAS
CHEBI:15651
ChEBI
Oxygen
ReactionCatalysis188
ACTIVATION
CHEBI:34151
ChEBI
ReactionCatalysis187
ACTIVATION
Arachidonate 15-lipoxygenase
Arachidonate 12-lipoxygenase, 12S-type
CHEBI:34157
ChEBI
Arachidonate 15-lipoxygenase B
Prostaglandin G/H synthase 1
Prostaglandin G/H synthase 2
Arachidonate 5-lipoxygenase
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
HMDB0002886
HMDB
Arachidonate 12-lipoxygenase, 12R-type
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
SMILES
CCCCC\C=C/C\C=C/C\C=C/CC1OC1CCCC(O)=O
C20H32O4
15H-11,12-EETA
336.23007
5,6-Epoxytetraene
GLT
BioCyc
53-57-6
CAS
1.0
Oxygen
4444059
ChemSpider
C20H32O4
12(S)-HPETE
336.23007
C20H32O4
15(S)-HPETE
336.23007
CHEBI:34146
ChEBI
ReactionCatalysis73
ACTIVATION
Prostaglandin-H2 D-isomerase
13345-50-1
CAS
ReactionCatalysis76
ACTIVATION
CHEBI:34145
ChEBI
ReactionCatalysis77
ACTIVATION
Prostaglandin E2
CHEBI:34144
ChEBI
P23219
UniProt
δ-12-Prostaglandin J2
SMILES
CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O
C20H32O3
14,15-Epoxy-5,8,11-eicosatrienoic acid
320.23514
1.0
Prostaglandin E synthase
Cytochrome P450 2B6
126873-49-2
CAS
14,15-Epoxy-5,8,11-eicosatrienoic acid
C20H32O5
Prostaglandin I2
352.22498
HMDB0011137
HMDB
HMDB0011136
HMDB
405289
ChemSpider
HMDB0011135
HMDB
HMDB0011134
HMDB
O15296
UniProt
C20H30O3
Leukotriene A4
318.21948
1.0
54397-85-2
CAS
HMDB0001335
HMDB
HMDB0001337
HMDB
CHEBI:15627
ChEBI
CHEBI:15626
ChEBI
CHEBI:15628
ChEBI
98462-03-4
CAS
1.0
HMDB0003080
HMDB
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
SMILES
[H][C@@](CCCCC)(OO)\C=C\[C@@]1([H])[C@@]2([H])C[C@]([H])(OO2)[C@]1([H])C\C=C/CCCC(O)=O
C20H34O5
11,12,15-THETA
354.24063
C20H32O4
5-HPETE
336.23007
C20H32O3
19(S)-HETE
320.23514
5255796
PubChem-compound
C20H32O3
5-HETE
320.23514
C20H32O4
12(R)-HPETE
336.23007
C20H34O5
11-Epi-PGF2a
354.24063
1.0
C20H32O3
11,12-Epoxyeicosatrienoic acid
320.23514
C20H32O3
8-HETE
320.23514
Glutathione peroxidase 1
C20H32O3
16(R)-HETE
320.23514
C20H30O4
5,6-Epoxytetraene
334.21442
C20H32O5
Prostaglandin D2
352.22498
4470730
ChemSpider
C20H30O4
Prostaglandin-c2
334.21442
C20H32O3
12(S)-HETE
320.23514
53480669
PubChem-compound
1.0
C20H32O3
12(R)-HETE
320.23514
1.0
SMILES
CCCCC[C@H](O)\C=C\[C@H]1OC(O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
1.0
Arachidonate 12-lipoxygenase, 12S-type
Cytoplasm
C20H32O4
11H-14,15-EETA
336.23007
C20H34O5
11,14,15-THETA
354.24063
10128355
ChemSpider
NADPH
10128354
ChemSpider
C20H32O4
8(S)-HPETE
336.23007
10128353
ChemSpider
4444411
ChemSpider
Cytochrome P450 2C8
4444412
ChemSpider
SMILES
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
CHEBI:34185
ChEBI
HMDB0060095
HMDB
Homo sapiens
Arachidonate 12-lipoxygenase, 12R-type
O2
Oxygen
31.98983
C20H28O3
15-Deoxy-d-12,14-PGJ2
316.20386
C20H32O5
Prostaglandin H2
352.22498
P78329
UniProt
Arachidonate 15-lipoxygenase B
P18054
UniProt
4444415
ChemSpider
4444416
ChemSpider
4444400
ChemSpider
4444401
ChemSpider
CHEBI:17858
ChEBI
HMDB0005050
HMDB
CHEBI:28728
ChEBI
107873
PubChem-compound
15H-11,12-EETA
C20H40
8-Isoprostane
280.313
CHEBI:27647
ChEBI
4444407
ChemSpider
4444408
ChemSpider
4444403
ChemSpider
4444405
ChemSpider
4444406
ChemSpider
4445566
ChemSpider
C00639
KEGG Compound
1.0
Thromboxane B2
5-HETE
1.0
Leukotriene-B(4) omega-hydroxylase 2
P16050
UniProt
5280724
PubChem-compound
15(S)-HETE
CHEBI:63970
ChEBI
Q16873
UniProt
12(S)-HPETE
8(S)-HPETE
5886
PubChem-compound
C20H30O3
12-KETE
318.21948
1.0
1.0
C14807
KEGG Compound
CHEBI:63969
ChEBI
CHEBI:63966
ChEBI
Leukotriene C4
HMDB0005079
HMDB
P05181
UniProt
41598-07-6
CAS
81276-02-0
CAS
C14815
KEGG Compound
5.3.99.4
false
5.3.99.4
Prostaglandin H2 → Prostaglandin I2
LEFT_TO_RIGHT
C13H11N3O4S2
Tenoxicam
337.0191
5.3.99.3
false
5.3.99.3
Prostaglandin H2 → Prostaglandin E2
LEFT_TO_RIGHT
1.0
C14814
KEGG Compound
P42330
UniProt
C14813
KEGG Compound
C14812
KEGG Compound
1.0
Prostaglandin H2
Prostaglandin E synthase
1.14.99.1
false
1.14.99.1
Arachidonic acid + 2 Oxygen → Prostaglandin G2
LEFT_TO_RIGHT
5.3.99.2
false
5.3.99.2
Prostaglandin H2 → Prostaglandin D2
LEFT_TO_RIGHT
CHEBI:63974
ChEBI
1.11.1.20
false
1.11.1.20
Prostaglandin H2 → Prostaglandin F2a
LEFT_TO_RIGHT
5280745
PubChem-compound
20-OH-LTB4
BioCyc
NADP
C00427
KEGG Compound
1.0
1.0
SMILES
NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O
5280733
PubChem-compound
C14823
KEGG Compound
10128338
ChemSpider
Arachidonate 5-lipoxygenase
10128337
ChemSpider
C14822
KEGG Compound
2,3-Dinor-8iso prostaglandin F2α