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Proton-coupled
folate
transporter
Dihydrofolate
reductase
Dihydrofolate
reductase
C-1-
tetrahydrofolate
synthase,
cytoplasmic
Cytosolic 10-
formyltetrahydrofolate
dehydrogenase
Formimidoyltransferase-
cyclodeaminase
C-1-
tetrahydrofolate
synthase,
cytoplasmic
5-
formyltetrahydrofolate
cyclo-ligase
C-1-
tetrahydrofolate
synthase,
cytoplasmic
Methylenetetrahydrofolate
reductase
Formimidoyltransferase-
cyclodeaminase
Folylpolyglutamate
synthase,
mitochondrial
Folylpolyglutamate
synthase,
mitochondrial
Gamma-glutamyl
hydrolase
Monofunctional
C1-
tetrahydrofolate
synthase,
mitochondrial
Bifunctional
methylenetetrahydrofolate
dehydrogenase/cyclohydrolase,
mitochondrial
Bifunctional
methylenetetrahydrofolate
dehydrogenase/cyclohydrolase,
mitochondrial
Methionyl-tRNA
formyltransferase,
mitochondrial
Tetrahydrofolic acid
Dihydrofolic acid
L-Glutamic acid
5-Formiminotetrahydrofolic
acid
5,10-Methylene-THF
5-Methyltetrahydrofolic acid
10-Formyltetrahydrofolate
Tetrahydrofolic acid
5,10-Methylene-THF
Folic acid
Folic acid
NADP
NADPH
NADP
NADPH
ATP
Formic acid
ADP
P
i
NADP
H
2
O
CO
2
NADPH
N5-Formyl-THF
N-Formyl-L-glutamic acid
H
+
5,10-Methenyltetrahydrofolic
acid
H
2
O
ATP
ADP
P
i
NADPH
NADP
NADH
NAD
NH
3
L-Glutamic acid
ATP
Tetrahydrofolyl-[Glu](2)
ADP
P
i
ATP
L-Glutamic acid
Tetrahydrofolyl-[Glu](n)
ADP
P
i
H
2
O
L-Glutamic acid
ATP
Formic acid
ADP
10-Formyltetrahydrofolate
P
i
H
+
5,10-Methenyltetrahydrofolic
acid
H
2
O
NADH
NAD
Pyridoxal
5'-phosphate
Magnesium
Pyridoxal
5'-phosphate
Calcium
Magnesium
Magnesium
L-
Methionyl-
tRNA(Met)
N-
formylmethionyl-
tRNA(fMet)
Histidine
Metabolism
Purine
Metabolism
Methionine
Metabolism
Glycine and
Serine
Metabolism
Pyrimidine
Metabolism
Glutamate
Metabolism
Histidine
Metabolism
Glycine and
Serine
Metabolism
Pyrimidine
Metabolism
Methionine
Metabolism
Purine
Metabolism
Glycine and
Serine
Metabolism
Glycine and
Serine
Metabolism
FAD
Calcium
Mitochondria
Lysosome
Extracellular Space
Intracellular Space
Mitochondrial matrix
Mitochondria
SLC46A1
DHFR
DHFR
MTHFD1
ALDH1L1
FTCD
MTHFD1
MTHFS
MTHFD1
MTHFR
FTCD
FPGS
FPGS
GGH
MTHFD1L
MTHFD2
MTHFD2
MTFMT
Tetrahydrofolic
acid
Dihydrofolic
acid
L-Glutamic acid
5-
Formiminotetrahydrofolic
acid
5,10-
Methylene-THF
5-
Methyltetrahydrofolic
acid
10-
Formyltetrahydrofolate
Tetrahydrofolic
acid
5,10-
Methylene-THF
Folic acid
Folic acid
NADP
NADPH
NADP
NADPH
Adenosine
triphosphate
Formic acid
Adenosine
diphosphate
Phosphate
NADP
Water
Carbon dioxide
NADPH
N5-Formyl-THF
N-Formyl-L-
glutamic acid
Hydrogen Ion
5,10-
Methenyltetrahydrofolic
acid
Water
Adenosine
triphosphate
Adenosine
diphosphate
Phosphate