474PathwayTemocapril Metabolism PathwayBenazepril, brand name Lotensin, belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can also be used in the treatment of congestive heart failure and type II diabetes. Benazepril is a prodrug which, following oral administration, undergoes biotransformation in vivo into its active form benazeprilat via cleavage of its ester group by the liver. Angiotensin-converting enzyme (ACE) is a component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I into the active vasoconstrictor angiotensin II. ACE (or kininase II) also degrades the potent vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.Drug MetabolismPW000709CenterPathwayVisualizationContext97814001000#000099PathwayVisualization455474Temocapril PathwayBenazepril, brand name Lotensin, belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can also be used in the treatment of congestive heart failure and type II diabetes. Benazepril is a prodrug which, following oral administration, undergoes biotransformation in vivo into its active form benazeprilat via cleavage of its ester group by the liver. Angiotensin-converting enzyme (ACE) is a component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I into the active vasoconstrictor angiotensin II. ACE (or kininase II) also degrades the potent vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.Drug127970216797382MacKinnon M, Shurraw S, Akbari A, Knoll GA, Jaffey J, Clark HD: Combination therapy with an angiotensin receptor blocker and an ACE inhibitor in proteinuric renal disease: a systematic review of the efficacy and safety data. Am J Kidney Dis. 2006 Jul;48(1):8-20. doi: 10.1053/j.ajkd.2006.04.077.474Pathway1CellCL:00000007Epithelial CellCL:00000661Homo sapiens9606EukaryoteHuman11Extracellular SpaceGO:000561510Cell MembraneGO:00058861LiverBTO:00007597298Blood VesselBTO:0001102741126LungBTO:000076329111PW_BS00002915111PW_BS0000155181PW_BS0000516612617PW_BS00050814101PW_BS00001440728TemocaprilHMDB0061720Temocapril belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Temocapril is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, temocapril is involved in the temocapril metabolism pathway and the temocapril action pathway.111902-57-9443874391964DB08836CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]1CS[C@@H](CN(CC(O)=O)C1=O)C1=CC=CS1C23H28N2O5S2InChI=1S/C23H28N2O5S2/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27)/t17-,18-,20-/m0/s1FIQOFIRCTOWDOW-BJLQDIEVSA-N2-[(2S,6R)-6-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid476.609476.143963396-5.142[(2S,6R)-6-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid0-1PW_C040728Temcpl51522940729TemocaprilatHMDB0061721Temocaprilat, also known as RS 5139, belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Temocaprilat is considered to be a practically insoluble (in water) and relatively neutral molecule. In humans, temocaprilat is involved in the temocapril metabolism pathway and the temocapril action pathway.110221-53-9C11373443151391423OC(=O)CN1C[C@H](SC[C@H](N[C@@H](CCC2=CC=CC=C2)C(O)=O)C1=O)C1=CC=CS1C21H24N2O5S2InChI=1S/C21H24N2O5S2/c24-19(25)12-23-11-18(17-7-4-10-29-17)30-13-16(20(23)26)22-15(21(27)28)9-8-14-5-2-1-3-6-14/h1-7,10,15-16,18,22H,8-9,11-13H2,(H,24,25)(H,27,28)/t15-,16-,18-/m0/s1KZVWEOXAPZXAFB-BQFCYCMXSA-N(2S)-2-{[(2S,6R)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino}-4-phenylbutanoic acid448.556448.112663268-4.763temocaprilat0-1Rs 5139PW_C040729Temoc5153295154151560Angiotensin-converting enzymeP12821Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moietyHMDBP01710ACE17q23.3EU33284013.2.1.-; 3.4.15.1291015295951331729136161661136548142339truePW_R002339Right9047407281Compoundfalse9048407291Compoundfalse282PW_T000282321407291Compound2915Right118814072829157false19540010regular200190118824072929157false58540010regular200190118834072915157false200115010regular200190632115602false57512108subunitregular1507018544M395 495 C425 495 540 495 585 495 5false18trueM 160.06440098298674 48.6115180941069 L 175 50 L 168.73466109469183 36.37115087758208false18545M195 495 C165 495 151 33 175 50 5true18trueM 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345false18546M685 590 C685 772 297 998 300 1150 83false18trueM 620.0644009829867 573.6115180941069 L 635 575 L 628.7346610946918 561.3711508775821false18547M300 1150 C300 1120 611 558 635 575 83true1818548M400 1245 C453 1246 516 1243 575 1245 148false18falsetrueM 549.329739888295 1089.2403672165249 L 558 1077 L 566.670260111705 1064.75963278347513349455233929110801188118544Left110811188218545Right4612824559851188218546Left9861188318547Right21418548986321100172195301.61.6029200145100274307601.21.20211580250790M128 449 C128 399 178 349 228 349 C386 349 591 349 749 349 C799 349 849 399 849 449 C849 483 849 526 849 560 C849 610 799 660 749 660 C591 660 386 660 228 660 C178 660 128 610 128 560 C128 526 128 483 128 449 1true6721.0311.05152811817531389569544820382516296917661119774137344708254