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Pathway Description
Operon: Nucleotide and Deoxyribonucleotide Catabolism Inactivation V
Escherichia coli
Category:
Protein Pathway
Sub-Categories:
Gene Regulatory
Cellular Response
Created: 2015-11-12
Last Updated: 2019-08-16
The nucleotide and deoxyribonucleotide operon is a polycistronic operon consisting of the genes DeoC, DeoA, DeoB and DeoD. This operon's transcription is activated by Fis DNA-binding transcriptional dual regulator binding to a -102 bp site off the promoter. This operon can also be activated by having CRP-cAMP DNA-binding transcriptional dual regulator binding either to -93.5 or -40.5. The repression of the operon's transcription can be controlled by multiple sites upsteam the promoter: - DeoR (DeoR DNA-binding transcriptional repressor) -887, -309, -8 for promoter deop2 and -609, -8, and 269 for promoter deop1 - CRP-cAMP DNA-binding transcriptional dual regulator binding at -93.5 for promoter deop2 - CytR (CytR DNA-binding transcriptional repressor) -87.5, -70.5, -61 for promoter deop2 -ModE-MoO42- DNA-binding transcriptional dual regulator -35 for promoter deop2
References
Operon: Nucleotide and Deoxyribonucleotide Catabolism Inactivation V References
Albrechtsen H, Ahmad SI: Regulation of the synthesis of nucleoside catabolic enzymes in Escherichia coli: further analysis of a deo Oc mutant strain. Mol Gen Genet. 1980;179(2):457-60.
Pubmed: 6780756
Amouyal M, Mortensen L, Buc H, Hammer K: Single and double loop formation when deoR repressor binds to its natural operator sites. Cell. 1989 Aug 11;58(3):545-51.
Pubmed: 2667765
Brikun I, Suziedelis K, Stemmann O, Zhong R, Alikhanian L, Linkova E, Mironov A, Berg DE: Analysis of CRP-CytR interactions at the Escherichia coli udp promoter. J Bacteriol. 1996 Mar;178(6):1614-22.
Pubmed: 8626289
Chahla M, Wooll J, Laue TM, Nguyen N, Senear DF: Role of protein-protein bridging interactions on cooperative assembly of DNA-bound CRP-CytR-CRP complex and regulation of the Escherichia coli CytR regulon. Biochemistry. 2003 Apr 8;42(13):3812-25. doi: 10.1021/bi0271143.
Pubmed: 12667072
Gavigan SA, Nguyen T, Nguyen N, Senear DF: Role of multiple CytR binding sites on cooperativity, competition, and induction at the Escherichia coli udp promoter. J Biol Chem. 1999 Jun 4;274(23):16010-9.
Pubmed: 10347150
Gerlach P, Sogaard-Andersen L, Pedersen H, Martinussen J, Valentin-Hansen P, Bremer E: The cyclic AMP (cAMP)-cAMP receptor protein complex functions both as an activator and as a corepressor at the tsx-p2 promoter of Escherichia coli K-12. J Bacteriol. 1991 Sep;173(17):5419-30.
Pubmed: 1715855
Svenningsen BA: Regulated in vitro synthesis of the enzymes of the deo operon of Escerichia coli. properties of the DNA directed system. Mol Gen Genet. 1975;137(4):289-304.
Pubmed: 810659
Walkenhorst HM, Hemschemeier SK, Eichenlaub R: Molecular analysis of the molybdate uptake operon, modABCD, of Escherichia coli and modR, a regulatory gene. Microbiol Res. 1995 Nov;150(4):347-61. doi: 10.1016/S0944-5013(11)80016-9.
Pubmed: 8564363
Grunden AM, Ray RM, Rosentel JK, Healy FG, Shanmugam KT: Repression of the Escherichia coli modABCD (molybdate transport) operon by ModE. J Bacteriol. 1996 Feb;178(3):735-44. doi: 10.1128/jb.178.3.735-744.1996.
Pubmed: 8550508
Oshima T, Aiba H, Baba T, Fujita K, Hayashi K, Honjo A, Ikemoto K, Inada T, Itoh T, Kajihara M, Kanai K, Kashimoto K, Kimura S, Kitagawa M, Makino K, Masuda S, Miki T, Mizobuchi K, Mori H, Motomura K, Nakamura Y, Nashimoto H, Nishio Y, Saito N, Horiuchi T, et al.: A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. DNA Res. 1996 Jun 30;3(3):137-55. doi: 10.1093/dnares/3.3.137.
Pubmed: 8905232
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