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Serine/threonine-
protein kinase
mTOR
Hypoxia-
inducible
factor 1-alpha
inhibitor
Myc
proto-oncogene
protein
Mitochondrial
pyruvate
carrier 1
Neutral amino
acid
transporter A
Sodium-coupled
neutral amino
acid
transporter 5
C-Myc-binding
protein
Monocarboxylate
transporter 1
Y+L amino acid
transporter 1
Oxoglutarate
dehydrogenase
complex
Succinyl-CoA
ligase
Pyruvate
carboxylase,
mitochondrial
Pyruvate
dehydrogenase
complex
Aconitate
hydratase,
mitochondrial
Aconitate
hydratase,
mitochondrial
Glutaminase
liver isoform,
mitochondrial
Uncharacterized
aminotransferase
yfdZ
Uncharacterized
aminotransferase
yfbQ
NADP-dependent
malic enzyme
L-lactate
dehydrogenase A
chain
Isocitrate
dehydrogenase
[NADP],
mitochondrial
ATP-citrate
synthase
Malate
dehydrogenase,
cytoplasmic
Fumarate
hydratase,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
flavoprotein
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
iron-sulfur
subunit,
mitochondrial
Succinate
dehydrogenase
cytochrome b560
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
cytochrome b
small subunit,
mitochondrial
citrate
synthase
Isocitrate
dehydrogenase
[NADP]
cytoplasmic
Glutamate
dehydrogenase
1,
mitochondrial
Aspartate
aminotransferase,
mitochondrial
ATP-citrate
synthase
Pyruvic acid
FADH
2
Pyruvic acid
L-Glutamine
L-Glutamine
L-Lactic acid
L-Lactic acid
L-Glutamine
L-Glutamine
L-Leucine
L-Leucine
Oxoglutaric acid
NAD
CoA
Succinyl-CoA
NADH
H
+
CO
2
P
i
GDP
CoA
GTP
ATP
Pyruvic acid
HCO
3
-
ADP
P
i
Oxalacetic acid
CoA
NAD
Acetyl-CoA
CO
2
NADH
Citric acid
cis-Aconitic acid
H
2
O
H
2
O
Isocitric acid
L-Glutamic acid
NH
3
Pyruvic acid
Oxoglutaric acid
L-Alanine
L-Malic acid
NADP
NADPH
H
+
CO
2
Pyruvic acid
NADH
H
+
NAD
CO
2
Citric acid
CoA
ATP
Oxalacetic acid
ADP
Acetyl-CoA
H
+
NADPH
NAD
Fumaric acid
H
2
O
Q
FAD
QH
2
NAD
H
+
NADH
H
+
CO
2
NAD
NADH
H
+
L-Aspartic acid
Oxaloacetate
CoA
ATP
Oxalacetic acid
ADP
Oxygen
Thiamine
pyrophosphate
Lipoamide
FAD
Biotin
Manganese
Thiamine
pyrophosphate
Lipoamide
FAD
Succinic acid
Aconitate
hydratase,
mitochondrial
Glycolysis
Mitochondrial
Electron
Transport Chain
Manganese
FAD
Pyridoxal
5'-phosphate
4Fe-4S
4Fe-4S
4Fe-4S
2Fe-2S
Mitochondrial matrix
Inner mitochondrial membrane
Outer mitochondrial membrane
Inner mitochondrial membrane
Mitochondrial intermembrane
space
Cytosol
Mitochondrion
Intracellular Space
Pseudo-Hypoxia
Mutant Aconitase
Mutant Aconitase
Lipid Synthesis
Extracellular Space