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Pathway Description
Phytate Biosynthesis
Arabidopsis thaliana
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2017-02-21
Last Updated: 2019-09-12
Phytate biosynthesis is a pathway that occurs in the cytosol by which myo-inositol becomes D-myo-inositol (1,3,4)-trisphosphate becomes phytate, the principal storage form of phosphorus in many plant tissues . First, myo-inositol-1,3,4-trisphosphate 5/6-kinase uses ATP to catalyze the conversion of D-myo-inositol (1,3,4)-trisphosphate into either D-myo-inositol (1,3,4,6)-tetrakisphosphate or D-myo-inositol (1,3,4,5)-tetrakisphosphate. It requires magnesium ion as a cofactor. Second, inositol polyphosphate multiple-kinase uses ATP to catalyze the conversion of either D-myo-inositol (1,3,4,6)-tetrakisphosphate or D-myo-inositol (1,3,4,5)-tetrakisphosphate into D-myo-inositol 1,3,4,5,6-pentakisphosphate. Third, polyphosphate 2-kinase uses ATP to catalyze the conversion of D-myo-inositol 1,3,4,5,6-pentakisphosphate into phytate. It requires zinc ion as a cofactor.
References
Phytate Biosynthesis References
Sweetman D, Johnson S, Caddick SE, Hanke DE, Brearley CA: Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1). Biochem J. 2006 Feb 15;394(Pt 1):95-103. doi: 10.1042/BJ20051331.
Pubmed: 16223361
Stevenson-Paulik J, Odom AR, York JD: Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. J Biol Chem. 2002 Nov 8;277(45):42711-8. doi: 10.1074/jbc.M209112200. Epub 2002 Sep 10.
Pubmed: 12226109
Wilson MP, Majerus PW: Characterization of a cDNA encoding Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase. Biochem Biophys Res Commun. 1997 Mar 27;232(3):678-81. doi: 10.1006/bbrc.1997.6355.
Pubmed: 9126335
Tabata S, Kaneko T, Nakamura Y, Kotani H, Kato T, Asamizu E, Miyajima N, Sasamoto S, Kimura T, Hosouchi T, Kawashima K, Kohara M, Matsumoto M, Matsuno A, Muraki A, Nakayama S, Nakazaki N, Naruo K, Okumura S, Shinpo S, Takeuchi C, Wada T, Watanabe A, Yamada M, Yasuda M, Sato S, de la Bastide M, Huang E, Spiegel L, Gnoj L, O'Shaughnessy A, Preston R, Habermann K, Murray J, Johnson D, Rohlfing T, Nelson J, Stoneking T, Pepin K, Spieth J, Sekhon M, Armstrong J, Becker M, Belter E, Cordum H, Cordes M, Courtney L, Courtney W, Dante M, Du H, Edwards J, Fryman J, Haakensen B, Lamar E, Latreille P, Leonard S, Meyer R, Mulvaney E, Ozersky P, Riley A, Strowmatt C, Wagner-McPherson C, Wollam A, Yoakum M, Bell M, Dedhia N, Parnell L, Shah R, Rodriguez M, See LH, Vil D, Baker J, Kirchoff K, Toth K, King L, Bahret A, Miller B, Marra M, Martienssen R, McCombie WR, Wilson RK, Murphy G, Bancroft I, Volckaert G, Wambutt R, Dusterhoft A, Stiekema W, Pohl T, Entian KD, Terryn N, Hartley N, Bent E, Johnson S, Langham SA, McCullagh B, Robben J, Grymonprez B, Zimmermann W, Ramsperger U, Wedler H, Balke K, Wedler E, Peters S, van Staveren M, Dirkse W, Mooijman P, Lankhorst RK, Weitzenegger T, Bothe G, Rose M, Hauf J, Berneiser S, Hempel S, Feldpausch M, Lamberth S, Villarroel R, Gielen J, Ardiles W, Bents O, Lemcke K, Kolesov G, Mayer K, Rudd S, Schoof H, Schueller C, Zaccaria P, Mewes HW, Bevan M, Fransz P: Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature. 2000 Dec 14;408(6814):823-6. doi: 10.1038/35048507.
Pubmed: 11130714
Cheng CY, Krishnakumar V, Chan AP, Thibaud-Nissen F, Schobel S, Town CD: Araport11: a complete reannotation of the Arabidopsis thaliana reference genome. Plant J. 2017 Feb;89(4):789-804. doi: 10.1111/tpj.13415. Epub 2017 Feb 10.
Pubmed: 27862469
Xu J, Brearley CA, Lin WH, Wang Y, Ye R, Mueller-Roeber B, Xu ZH, Xue HW: A role of Arabidopsis inositol polyphosphate kinase, AtIPK2alpha, in pollen germination and root growth. Plant Physiol. 2005 Jan;137(1):94-103. doi: 10.1104/pp.104.045427. Epub 2004 Dec 23.
Pubmed: 15618435
Stevenson-Paulik J, Bastidas RJ, Chiou ST, Frye RA, York JD: Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12612-7. doi: 10.1073/pnas.0504172102. Epub 2005 Aug 17.
Pubmed: 16107538
Nakamura Y, Sato S, Kaneko T, Kotani H, Asamizu E, Miyajima N, Tabata S: Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence features of the regions of 1,191,918 bp covered by seventeen physically assigned P1 clones. DNA Res. 1997 Dec 31;4(6):401-14. doi: 10.1093/dnares/4.6.401.
Pubmed: 9501997
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