Gβ
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState777

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reaction217703
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000457/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium ← Potassium
conversion direction: RIGHT_TO_LEFT

Protein/1340 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase subunit beta
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Stomach
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001307

Gβ
type: Protein
cellular location: Basolateral cell membrane
entity reference: Gβ

ChemicalStructure/PW C000693
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC=N1

direct_interaction
type: InteractionVocabulary

Reference/HMDB HMDB0000895
type: UnificationXref
id: HMDB0000895
db: HMDB

Reference/UniProt P00915
type: UnificationXref
id: P00915
db: UniProt

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

TransportCatalysis114
type: Catalysis
controller: Chloride intracellular channel protein 2
controlled: Transport54
control type: ACTIVATION

Reference/UniProt P20648
type: UnificationXref
id: P20648
db: UniProt

Apical cell membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016324

Acetylcholine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15355
xref: Reference/CAS 51-84-3
xref: Reference/HMDB HMDB0000895
xref: Reference/ChemSpider 182
xref: Reference/KEGG Compound C01996
xref: Reference/BioCyc ACETYLCHOLINE
xref: Reference/PubChem-compound 187
chemical formula: C7H16NO2
molecular weight: 146.1181
structure: ChemicalStructure/PW C000714

Histamine H2 receptor
type: Protein
cellular location: Cell Membrane
entity reference: Histamine H2 receptor
name: SubPathwayInput
name: SubPathwayActivation

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: Reference/UniProt Q9UBI6
organism: BiologicalState777

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 31759
type: UnificationXref
id: CHEBI:31759
db: ChEBI

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Muscarinic acetylcholine receptor M3
type: Protein
entity reference: Muscarinic acetylcholine receptor M3
name: SubPathwayInput
name: SubPathwayActivation

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/PathWhiz PW000728
type: UnificationXref
id: PW000728
db: PathWhiz

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/HMDB HMDB0240216
type: UnificationXref
id: HMDB0240216
db: HMDB

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C00698
type: UnificationXref
id: C00698
db: KEGG Compound

Acetylcholine
type: SmallMolecule
entity reference: Acetylcholine
name: SubPathwayActivator

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Compound/PW C000457 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbon dioxide

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/UniProt P20309
type: UnificationXref
id: P20309
db: UniProt

Chloride ion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17996
xref: Reference/BioCyc CPD-4521
xref: Reference/PubChem-compound 312
xref: Reference/KEGG Compound C00698
xref: Reference/HMDB HMDB0000492
xref: Reference/ChemSpider 306
xref: Reference/CAS 16887-00-6
chemical formula: Cl
molecular weight: 34.968853
structure: ChemicalStructure/PW C000374

Reference/BioCyc ACETYLCHOLINE
type: UnificationXref
id: ACETYLCHOLINE
db: BioCyc

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Reference/UniProt P01350
type: UnificationXref
id: P01350
db: UniProt

Reference/ChemSpider 4445337
type: UnificationXref
id: 4445337
db: ChemSpider

Compound/PW C000463 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Compound/PW C000374 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Somatostatin receptor type 2
type: Protein
cellular location: Apical cell membrane
entity reference: Somatostatin receptor type 2
name: SubPathwayOutput

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Potassium-transporting ATPase subunit beta
type: ProteinReference
xref: Reference/UniProt P51164
organism: Homo sapiens

Compound/PW C000936 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Protein/1354 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase alpha chain 1
stoichiometric coefficient: 1.0

H(+)/K(+) ATPase subunit
type: Complex
component stoichiometry: Protein/1340 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1354 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Potassium-transporting ATPase subunit beta
component: Potassium-transporting ATPase alpha chain 1
name: SubPathwayOutput

SSTR2
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116642
pathway component: SubPathwayInteraction116642
name: SubPathway

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Hydrogen Ion

Gastrin/cholecystokinin type B receptor
type: Protein
cellular location: Cell Membrane
entity reference: Gastrin/cholecystokinin type B receptor
name: SubPathwayActivation

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Potassium-transporting ATPase alpha chain 1
type: ProteinReference
xref: Reference/UniProt P20648
organism: Homo sapiens

Chloride intracellular channel protein 2
type: ProteinReference
xref: Reference/UniProt O15247

Potassium voltage-gated channel subfamily E member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily E member 2

Protein/1816 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histamine H2 receptor
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000374
type: ChemicalStructure
structure format: SMILES
structure data: [Cl-]

Compound/PW C000463/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Potassium voltage-gated channel subfamily KQT member 1
type: Protein
entity reference: Potassium voltage-gated channel subfamily KQT member 1

Chloride ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Chloride ion

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Parietal Cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000162

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/PubChem-compound 312
type: UnificationXref
id: 312
db: PubChem-compound

Reference/UniProt P30874
type: UnificationXref
id: P30874
db: UniProt

ReactionCatalysis1409
type: Catalysis
controller: Carbonic anhydrase 1
controlled: 4.2.1.1
control type: ACTIVATION

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt P61278
type: UnificationXref
id: P61278
db: UniProt

Lafutidine
type: SmallMoleculeReference
xref: Reference/ChemSpider 4445337
xref: Reference/ChEBI CHEBI 31759
xref: Reference/PubChem-compound 5282136
xref: Reference/HMDB HMDB0240216
xref: Reference/CAS 118288-08-7
chemical formula: C22H29N3O4S
molecular weight: 431.18787
structure: ChemicalStructure/PW C096732

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Transport54
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
right: Chloride ion
spontaneous: false
left: Chloride ion
name: Chloride ion (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Lafutidine H2 Anti-Histamine Action Pathway
type: Pathway
pathway order: PathwaySubPathway/488
pathway order: PathwaySubPathway/485
pathway order: PathwaySubPathway/483
pathway order: PathwaySubPathway/484
pathway order: PathwaySubPathway/482
pathway order: PathwaySubPathway/489
pathway order: PathwayEnzymeReaction/1943
pathway order: PathwayTransport/1941
pathway order: PathwayEnzymeReaction/2499366
pathway order: PathwaySubPathway/116642
pathway order: PathwayInteraction/3465
pathway order: PathwayTransport/2123649
pathway order: PathwayEnzymeReaction/211633
pathway component: SubPathwayControl483
pathway component: Reaction217703
pathway component: SubPathwayControl484
pathway component: SubPathwayControl485
pathway component: Interaction3465
pathway component: ReactionCatalysis1409
pathway component: SubPathwayControl489
pathway component: Transport10327
pathway component: Transport54
pathway component: 4.2.1.1
pathway component: ReactionCatalysis207262
pathway component: 3.6.3.10
pathway component: ReactionCoupledTransportCatalysis13
pathway component: TransportCatalysis114
pathway component: SSTR2
pathway component: G-Protein Signaling Cascade
xref: Reference/SMPDB SMP0051038
xref: Reference/PathWhiz PW051946
organism: Homo sapiens

Protein/1601 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Protein/3625 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
stoichiometric coefficient: 1.0

Potassium
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Potassium

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: Protein
cellular location: Basolateral cell membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gastrin
type: ProteinReference
xref: Reference/UniProt P01350
organism: Homo sapiens

Muscarinic acetylcholine receptor M3
type: ProteinReference
xref: Reference/UniProt P20309

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Gastrin/cholecystokinin type B receptor
type: Protein
entity reference: Gastrin/cholecystokinin type B receptor
name: SubPathwayActivator

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Histamine H2 receptor
type: ProteinReference
xref: Reference/UniProt P25021
organism: BiologicalState777

SubPathwayInteraction488
type: Interaction
name: SubPathwayReaction
name: SubPathway488Reaction
participant: H(+)/K(+) ATPase subunit
participant: Muscarinic acetylcholine receptor M3

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00388
type: UnificationXref
id: C00388
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/SMPDB SMP0000751
type: UnificationXref
id: SMP0000751
db: SMPDB

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

SubPathwayInteraction482
type: Interaction
name: SubPathwayReaction
name: SubPathway482Reaction
participant: Histamine H2 receptor
participant: H(+)/K(+) ATPase subunit

Compound/PW C000457/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Interaction3465
type: MolecularInteraction
interaction type: direct_interaction
name: Lafutidine inhibits Histamine H2 receptor (Homo sapiens) + Guanine nucleotide-binding protein alpha (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens) + Guanosine diphosphate
participant: Lafutidine
participant: BoundComplex/527 Basolateral cell membrane

Potassium
type: SmallMolecule
entity reference: Potassium

Reference/SMPDB SMP0051038
type: UnificationXref
id: SMP0051038
db: SMPDB

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Transport10327
type: Transport
participant stoichiometry: Compound/PW C000463/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Cytoplasm/Stoichiometry/1.0
right: Hydrogen carbonate
spontaneous: false
left: Hydrogen carbonate
name: Hydrogen carbonate (→) Transport: Homo sapiens, Stomach, Parietal Cell, Cytoplasm to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/CAS 51-45-6
type: UnificationXref
id: 51-45-6
db: CAS

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Basolateral cell membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016323

Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/UniProt P51787
type: UnificationXref
id: P51787
db: UniProt

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000492
type: UnificationXref
id: HMDB0000492
db: HMDB

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/ChEBI CHEBI 17996
type: UnificationXref
id: CHEBI:17996
db: ChEBI

Potassium voltage-gated channel subfamily KQT member 1
type: ProteinReference
xref: Reference/UniProt P51787
organism: BiologicalState778

Potassium voltage-gated channel subfamily E member 2
type: ProteinReference
xref: Reference/UniProt Q9Y6J6
organism: BiologicalState778

Somatostatin receptor type 2
type: ProteinReference
xref: Reference/UniProt P30874
organism: BiologicalState777

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: ProteinReference
xref: Reference/UniProt P63092
organism: BiologicalState777

Reference/PathWhiz PW051946
type: UnificationXref
id: PW051946
db: PathWhiz

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Reference/CAS 16887-00-6
type: UnificationXref
id: 16887-00-6
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

SubPathwayInteraction116642
type: Interaction
name: SubPathway116642Reaction
name: SubPathwayReaction
participant: Somatostatin
participant: Somatostatin receptor type 2

Reference/UniProt P63092
type: UnificationXref
id: P63092
db: UniProt

Reference/PubChem-compound 5282136
type: UnificationXref
id: 5282136
db: PubChem-compound

Histamine Activation of Histamine H2 Receptor
type: Pathway
name: ActivatingSubPathway

Gastrin Activation of Gastrin/cholecystokinin type B receptor
type: Pathway
name: ActivatingSubPathway

Guanosine diphosphate
type: SmallMolecule
cellular location: Basolateral cell membrane
entity reference: Guanosine diphosphate

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Acetylcholine activation of Muscarinic acetylcholine receptor M3
type: Pathway
name: ActivatingSubPathway

Reference/CAS 51-84-3
type: UnificationXref
id: 51-84-3
db: CAS

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen carbonate

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Lafutidine
type: SmallMolecule
cellular location: Basolateral cell membrane
entity reference: Lafutidine

4.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Hydrogen carbonate
spontaneous: false
EC number: 4.2.1.1
left: Carbon dioxide
left: Water
name: Carbon dioxide + Water → Hydrogen Ion + Hydrogen carbonate
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Somatostatin
type: Protein
cellular location: Extracellular Space
entity reference: Somatostatin
name: SubPathwayInput

Carbonic anhydrase 1
type: Protein
cellular location: Cytoplasm
entity reference: Carbonic anhydrase 1

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Protein/3618 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβ
stoichiometric coefficient: 1.0

Gastrin/cholecystokinin type B receptor
type: ProteinReference
xref: Reference/UniProt P32239
organism: Homo sapiens

Reference/PubChem-compound 774
type: UnificationXref
id: 774
db: PubChem-compound

Reference/UniProt P32239
type: UnificationXref
id: P32239
db: UniProt

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/UniProt P25021
type: UnificationXref
id: P25021
db: UniProt

Reference/ChemSpider 306
type: UnificationXref
id: 306
db: ChemSpider

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ChemicalStructure/PW C000714
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OCC[N+](C)(C)C

Compound/PW C040034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/UniProt Q9Y6J6
type: UnificationXref
id: Q9Y6J6
db: UniProt

KCNE2/KCNQ1 Channel
type: Complex
component: Potassium voltage-gated channel subfamily KQT member 1
component: Potassium voltage-gated channel subfamily E member 2

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Basolateral cell membrane
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/CELL TYPE ONTOLOGY CL 0000162
type: UnificationXref
id: CL:0000162
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/UniProt O15247
type: UnificationXref
id: O15247
db: UniProt

ReactionCoupledTransportCatalysis13
type: Catalysis
controller: H(+)/K(+) ATPase subunit
controlled: 3.6.3.10
control type: ACTIVATION

Histamine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Histamine
name: SubPathwayActivator

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

G-Protein Signaling Cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway488
pathway order: SubPathwayInteractionSteps/SubPathway482
pathway component: SubPathwayInteraction488
pathway component: SubPathwayInteraction482
xref: Reference/SMPDB SMP0000751
xref: Reference/PathWhiz PW000728
name: SubPathway

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

H(+)/K(+) ATPase subunit
type: Complex
component stoichiometry: Protein/1340/Stoichiometry/1.0
component stoichiometry: Protein/1354/Stoichiometry/1.0
component: Potassium-transporting ATPase subunit beta
component: Potassium-transporting ATPase alpha chain 1
name: SubPathwayOutput
name: SubPathwayActivation

Histamine H2 receptor
type: Protein
cellular location: Basolateral cell membrane
entity reference: Histamine H2 receptor

Somatostatin
type: ProteinReference
xref: Reference/UniProt P61278
organism: BiologicalState778

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Carbonic anhydrase 1
type: ProteinReference
xref: Reference/UniProt P00915
organism: Homo sapiens

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc HISTAMINE
type: UnificationXref
id: HISTAMINE
db: BioCyc

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Chloride ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Chloride ion

Protein/1354/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase alpha chain 1
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0001307
type: UnificationXref
id: BTO:0001307
db: BRENDA TISSUE ONTOLOGY

BoundComplex/527 Basolateral cell membrane
type: Complex
display name: Histamine H2 receptor (Homo sapiens)_Guanine nucleotide-binding protein alpha (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)_Guanosine diphosphate
component stoichiometry: Protein/3618 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/1601 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000936 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/3625 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/1816 Basolateral cell membrane/Stoichiometry/1.0
cellular location: Basolateral cell membrane
component: Histamine H2 receptor
component: Guanosine diphosphate
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
component: Gβ

Reference/BioCyc CPD-4521
type: UnificationXref
id: CPD-4521
db: BioCyc

SubPathwayControl483
type: Interaction
name: SubPathway483Control
name: ActivatingSubPathwayControl
participant: Histamine H2 receptor
participant: Histamine Activation of Histamine H2 Receptor
participant: Histamine

SubPathwayControl484
type: Interaction
name: SubPathway484Control
name: ActivatingSubPathwayControl
participant: Gastrin Activation of Gastrin/cholecystokinin type B receptor
participant: Gastrin/cholecystokinin type B receptor
participant: Gastrin

SubPathwayControl485
type: Interaction
name: SubPathway485Control
name: ActivatingSubPathwayControl
participant: H(+)/K(+) ATPase subunit
participant: G-Protein Signaling Cascade
participant: Gastrin/cholecystokinin type B receptor

Reference/GENE ONTOLOGY GO 0016323
type: UnificationXref
id: GO:0016323
db: GENE ONTOLOGY

SubPathwayControl489
type: Interaction
name: SubPathway489Control
name: ActivatingSubPathwayControl
participant: Muscarinic acetylcholine receptor M3
participant: Acetylcholine
participant: Acetylcholine activation of Muscarinic acetylcholine receptor M3

Reference/GENE ONTOLOGY GO 0016324
type: UnificationXref
id: GO:0016324
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 18295
type: UnificationXref
id: CHEBI:18295
db: ChEBI

Reference/PubChem-compound 187
type: UnificationXref
id: 187
db: PubChem-compound

Reference/HMDB HMDB0000870
type: UnificationXref
id: HMDB0000870
db: HMDB

Reference/ChemSpider 753
type: UnificationXref
id: 753
db: ChemSpider

Potassium-transporting ATPase subunit beta
type: Protein
entity reference: Potassium-transporting ATPase subunit beta

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ReactionCatalysis207262
type: Catalysis
controller: KCNE2/KCNQ1 Channel
controlled: Reaction217703
control type: ACTIVATION

Histamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000870
xref: Reference/ChemSpider 753
xref: Reference/PubChem-compound 774
xref: Reference/BioCyc HISTAMINE
xref: Reference/CAS 51-45-6
xref: Reference/ChEBI CHEBI 18295
xref: Reference/KEGG Compound C00388
chemical formula: C5H9N3
molecular weight: 111.07965
structure: ChemicalStructure/PW C000693

Reference/UniProt P51164
type: UnificationXref
id: P51164
db: UniProt

Gastrin
type: Protein
cellular location: Cell Membrane
entity reference: Gastrin
name: SubPathwayActivator

Reference/ChEBI CHEBI 15355
type: UnificationXref
id: CHEBI:15355
db: ChEBI

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Potassium-transporting ATPase alpha chain 1
type: Protein
cellular location: Cell Membrane
entity reference: Potassium-transporting ATPase alpha chain 1

ChemicalStructure/PW C096732
type: ChemicalStructure
structure format: SMILES
structure data: O=C(CS(=O)CC1=CC=CO1)NC\C=C/COC1=NC=CC(CN2CCCCC2)=C1

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Reference/KEGG Compound C01996
type: UnificationXref
id: C01996
db: KEGG Compound

Reference/CAS 118288-08-7
type: UnificationXref
id: 118288-08-7
db: CAS

BiologicalState778
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Stomach
tissue: Stomach

BiologicalState777
type: BioSource
cell type: Parietal Cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Stomach, Parietal Cell
tissue: Stomach

Protein/1340/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase subunit beta
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

Potassium-transporting ATPase subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: Potassium-transporting ATPase subunit beta

Hydrogen carbonate
type: SmallMolecule
entity reference: Hydrogen carbonate

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Chloride intracellular channel protein 2
type: Protein
entity reference: Chloride intracellular channel protein 2

3.6.3.10
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000457 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Hydrogen Ion
right: Potassium
spontaneous: false
EC number: 3.6.3.10
left: Hydrogen Ion
left: Adenosine triphosphate
left: Water
left: Potassium
name: Adenosine triphosphate + Hydrogen Ion + Potassium + Water → Adenosine diphosphate + Hydrogen Ion + Phosphate + Potassium
conversion direction: LEFT_TO_RIGHT

Potassium-transporting ATPase alpha chain 1
type: Protein
entity reference: Potassium-transporting ATPase alpha chain 1

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/ChemSpider 182
type: UnificationXref
id: 182
db: ChemSpider

Reference/UniProt Q9UBI6
type: UnificationXref
id: Q9UBI6
db: UniProt