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<bp:SmallMolecule rdf:ID="Compound/PW_C000936_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Guanosine diphosphate</bp:displayName>
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<bp:ChemicalStructure rdf:ID="ChemicalStructure/PW_C000693">
 <bp:structureFormat rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">SMILES</bp:structureFormat>
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<bp:SmallMolecule rdf:ID="Compound/Generic295_Cytoplasm">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">1,2-Diacyl-sn-glycerol</bp:displayName>
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<bp:Complex rdf:ID="ProteinComplex/270">
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<bp:SmallMolecule rdf:ID="Compound/PW_C000693">
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<bp:ChemicalStructure rdf:ID="ChemicalStructure/PW_C001420">
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<bp:SmallMolecule rdf:ID="Compound/PW_C000353_Cytoplasm">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Calcium</bp:displayName>
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<bp:UnificationXref rdf:ID="Reference/UniProt_P05771">
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<bp:UnificationXref rdf:ID="Reference/KEGG_Compound_C00044">
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<bp:SmallMolecule rdf:ID="Compound/PW_C001420_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Water</bp:displayName>
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</bp:SmallMolecule>

<bp:Protein rdf:ID="Protein/1740_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Guanine nucleotide-binding protein G(q) subunit alpha</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:entityReference rdf:resource="#ProteinReference/1740" />
</bp:Protein>

<bp:Pathway rdf:ID="SubPathways/53241">
 <bp:pathwayOrder rdf:resource="#SubPathwayInteractionSteps/SubPathway53241" />
 <bp:pathwayComponent rdf:resource="#SubPathwayInteractions/53241" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Mast Cells Release Histamine</bp:displayName>
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">SubPathway</bp:name>
</bp:Pathway>

<bp:Stoichiometry rdf:ID="Compound/PW_C001420_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#Compound/PW_C001420_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:ChemicalStructure rdf:ID="ChemicalStructure/PW_C001155">
 <bp:structureFormat rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">SMILES</bp:structureFormat>
 <bp:structureData rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O</bp:structureData>
</bp:ChemicalStructure>

<bp:Protein rdf:ID="Protein/2116_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Histamine H1 receptor</bp:displayName>
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 <bp:entityReference rdf:resource="#ProteinReference/2116" />
</bp:Protein>

<bp:Catalysis rdf:ID="TransportCatalysis/922">
 <bp:controller rdf:resource="#ProteinComplex/270" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">TransportCatalysis922</bp:displayName>
 <bp:controlled rdf:resource="#Transports/1035" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Catalysis>

<bp:Stoichiometry rdf:ID="Protein/2126/Stoichiometry/4.0">
 <bp:physicalEntity rdf:resource="#Protein/2126" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">4.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:CellularLocationVocabulary rdf:ID="CellularLocation/Cytoplasm">
 <bp:xref rdf:resource="#Reference/GENE_ONTOLOGY_GO_0005737" />
 <bp:term rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Cytoplasm</bp:term>
</bp:CellularLocationVocabulary>

<bp:SmallMoleculeReference rdf:ID="CompoundReference/PW_C009653">
 <bp:xref rdf:resource="#Reference/KEGG_Compound_C07172" />
 <bp:xref rdf:resource="#Reference/HMDB_HMDB0015376" />
 <bp:xref rdf:resource="#Reference/ChemSpider_5373" />
 <bp:xref rdf:resource="#Reference/CAS_84-96-8" />
 <bp:xref rdf:resource="#Reference/ChEBI_CHEBI_157833" />
 <bp:xref rdf:resource="#Reference/PubChem-compound_5574" />
 <bp:chemicalFormula rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">C18H22N2S</bp:chemicalFormula>
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Alimemazine</bp:displayName>
 <bp:molecularWeight rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">298.15036</bp:molecularWeight>
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<bp:Stoichiometry rdf:ID="Compound/PW_C000986_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#Compound/PW_C000986_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:PathwayStep rdf:ID="PathwaySubPathway/53241">
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</bp:PathwayStep>

<bp:UnificationXref rdf:ID="Reference/UniProt_P59768">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">P59768</bp:id>
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</bp:UnificationXref>

<bp:BioSource rdf:ID="Species/1">
 <bp:xref rdf:resource="#Reference/TAXONOMY_9606" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Homo sapiens</bp:displayName>
</bp:BioSource>

<bp:BiochemicalReaction rdf:ID="Reactions/101579">
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 <bp:participantStoichiometry rdf:resource="#BoundComplex/27_Cell_Membrane/Stoichiometry/1.0" />
 <bp:participantStoichiometry rdf:resource="#BoundComplex/26_Cell_Membrane/Stoichiometry/1.0" />
 <bp:participantStoichiometry rdf:resource="#BoundComplex/24_Cell_Membrane/Stoichiometry/1.0" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Reaction101579</bp:displayName>
 <bp:right rdf:resource="#BoundComplex/27_Cell_Membrane" />
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 <bp:right rdf:resource="#ProteinComplex/6637_Cell_Membrane" />
 <bp:spontaneous rdf:datatype = "http://www.w3.org/2001/XMLSchema#boolean">false</bp:spontaneous>
 <bp:left rdf:resource="#BoundComplex/24_Cell_Membrane" />
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Histamine H1 receptor (Homo sapiens) + G&#945;q (Homo sapiens) + Guanosine diphosphate + G&#946;&#947; (Homo sapiens) &amp;rarr; Guanosine triphosphate + G&#945;q (Homo sapiens) + G&#946;&#947; + Histamine + Histamine H1 receptor (Homo sapiens)</bp:name>
 <bp:conversionDirection rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">LEFT_TO_RIGHT</bp:conversionDirection>
</bp:BiochemicalReaction>

<bp:Pathway rdf:about="http://identifiers.org/smpdb/SMP0059689">
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 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Alimemazine H1-Antihistamine Action</bp:displayName>
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<bp:BiochemicalReaction rdf:ID="Reactions/100922">
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 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Reaction100922</bp:displayName>
 <bp:right rdf:resource="#Compound/Generic295_Cell_Membrane" />
 <bp:right rdf:resource="#Compound/PW_C001155_Cell_Membrane" />
 <bp:spontaneous rdf:datatype = "http://www.w3.org/2001/XMLSchema#boolean">false</bp:spontaneous>
 <bp:left rdf:resource="#Compound/PW_C001420_Cell_Membrane" />
 <bp:left rdf:resource="#Compound/Generic344_Cell_Membrane" />
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Water + phosphatidylinositol 4,5-bisphosphate &amp;rarr; 1,2-Diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate</bp:name>
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</bp:BiochemicalReaction>

<bp:Protein rdf:ID="Protein/1591_Cell_Membrane">
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 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:entityReference rdf:resource="#ProteinReference/1591" />
</bp:Protein>

<bp:UnificationXref rdf:ID="Reference/CAS_7732-18-5">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">7732-18-5</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CAS</bp:db>
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<bp:UnificationXref rdf:ID="Reference/ChEBI_CHEBI_16595">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CHEBI:16595</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChEBI</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/UniProt_Q9NQ66">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Q9NQ66</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">UniProt</bp:db>
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<bp:UnificationXref rdf:ID="Reference/PubChem-compound_439456">
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</bp:UnificationXref>

<bp:Stoichiometry rdf:ID="Protein/2116_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#Protein/2116_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:Stoichiometry rdf:ID="ProteinComplex/6637_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#ProteinComplex/6637_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
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<bp:PathwayStep rdf:ID="PathwayInteraction/280">
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<bp:UnificationXref rdf:ID="Reference/CAS_85166-31-0">
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<bp:UnificationXref rdf:ID="Reference/GENE_ONTOLOGY_GO_0005783">
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 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">GENE ONTOLOGY</bp:db>
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<bp:MolecularInteraction rdf:ID="Interactions/241">
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 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Interaction241</bp:displayName>
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Guanosine triphosphate + G&#945;q (Homo sapiens) activates Phospholipase C, beta 1</bp:name>
 <bp:participant rdf:resource="#BoundComplex/26_Cell_Membrane" />
 <bp:participant rdf:resource="#Protein/216_Cell_Membrane" />
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<bp:UnificationXref rdf:ID="Reference/PubChem-compound_774">
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<bp:MolecularInteraction rdf:ID="Interactions/240">
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 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Interaction240</bp:displayName>
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Histamine activates Histamine H1 receptor (Homo sapiens) + G&#945;q (Homo sapiens) + Guanosine diphosphate + G&#946;&#947; (Homo sapiens)</bp:name>
 <bp:participant rdf:resource="#BoundComplex/24_Cell_Membrane" />
 <bp:participant rdf:resource="#Compound/PW_C000693_Cell_Membrane" />
</bp:MolecularInteraction>

<bp:MolecularInteraction rdf:ID="Interactions/243">
 <bp:interactionType rdf:resource="#InteractionVocabulary/direct_interaction" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Interaction243</bp:displayName>
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">1,2-Diacyl-sn-glycerol activates protein kinase C beta</bp:name>
 <bp:participant rdf:resource="#Compound/Generic295_Cytoplasm" />
 <bp:participant rdf:resource="#Protein/1279_Cytoplasm" />
</bp:MolecularInteraction>

<bp:MolecularInteraction rdf:ID="Interactions/242">
 <bp:interactionType rdf:resource="#InteractionVocabulary/direct_interaction" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Interaction242</bp:displayName>
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1</bp:name>
 <bp:participant rdf:resource="#ProteinComplex/270_Endoplasmic_Reticulum" />
 <bp:participant rdf:resource="#Compound/PW_C001155_Endoplasmic_Reticulum" />
</bp:MolecularInteraction>

<bp:MolecularInteraction rdf:ID="Interactions/245">
 <bp:interactionType rdf:resource="#InteractionVocabulary/direct_interaction" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Interaction245</bp:displayName>
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">protein kinase C beta activates Nuclear factor NF-kappa-B p105 subunit</bp:name>
 <bp:participant rdf:resource="#Protein/1279_Nucleus" />
 <bp:participant rdf:resource="#Protein/1808_Nucleus" />
</bp:MolecularInteraction>

<bp:MolecularInteraction rdf:ID="Interactions/244">
 <bp:interactionType rdf:resource="#InteractionVocabulary/direct_interaction" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Interaction244</bp:displayName>
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Calcium activates protein kinase C beta</bp:name>
 <bp:participant rdf:resource="#Protein/1279_Cytoplasm" />
 <bp:participant rdf:resource="#Compound/PW_C000353_Cytoplasm" />
</bp:MolecularInteraction>

<bp:UnificationXref rdf:ID="Reference/UniProt_P19838">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">P19838</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">UniProt</bp:db>
</bp:UnificationXref>

<bp:Protein rdf:ID="Protein/1808_Nucleus">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Nuclear factor NF-kappa-B p105 subunit</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Nucleus" />
 <bp:entityReference rdf:resource="#ProteinReference/1808" />
</bp:Protein>

<bp:Protein rdf:ID="Protein/2126">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Inositol 1,4,5-trisphosphate receptor type 1</bp:displayName>
 <bp:entityReference rdf:resource="#ProteinReference/2126" />
</bp:Protein>

<bp:ProteinReference rdf:ID="ProteinReference/1740">
 <bp:xref rdf:resource="#Reference/UniProt_P50148" />
 <bp:organism rdf:resource="#Species/1" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Guanine nucleotide-binding protein G(q) subunit alpha</bp:displayName>
</bp:ProteinReference>

<bp:UnificationXref rdf:ID="Reference/PubChem-compound_8977">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">8977</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">PubChem-compound</bp:db>
</bp:UnificationXref>

<bp:SmallMolecule rdf:ID="Compound/PW_C001155_Endoplasmic_Reticulum">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Inositol 1,4,5-trisphosphate</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Endoplasmic_Reticulum" />
 <bp:entityReference rdf:resource="#CompoundReference/PW_C001155" />
</bp:SmallMolecule>

<bp:UnificationXref rdf:ID="Reference/PubChem-compound_6830">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">6830</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">PubChem-compound</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/HMDB_HMDB0015376">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB0015376</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB</bp:db>
</bp:UnificationXref>

<bp:Catalysis rdf:ID="ReactionCatalysis/91035">
 <bp:controller rdf:resource="#Protein/216_Cell_Membrane" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ReactionCatalysis91035</bp:displayName>
 <bp:controlled rdf:resource="#Reactions/100922" />
 <bp:controlType rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ACTIVATION</bp:controlType>
</bp:Catalysis>

<bp:ProteinReference rdf:ID="ProteinReference/216">
 <bp:xref rdf:resource="#Reference/UniProt_Q9NQ66" />
 <bp:organism rdf:resource="#Species/1" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1</bp:displayName>
</bp:ProteinReference>

<bp:SmallMoleculeReference rdf:ID="CompoundReference/PW_C000936">
 <bp:xref rdf:resource="#Reference/HMDB_HMDB0001201" />
 <bp:xref rdf:resource="#Reference/BioCyc_GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE" />
 <bp:xref rdf:resource="#Reference/CAS_146-91-8" />
 <bp:xref rdf:resource="#Reference/PubChem-compound_8977" />
 <bp:xref rdf:resource="#Reference/ChEBI_CHEBI_17552" />
 <bp:xref rdf:resource="#Reference/ChemSpider_8630" />
 <bp:xref rdf:resource="#Reference/KEGG_Compound_C00035" />
 <bp:chemicalFormula rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">C10H15N5O11P2</bp:chemicalFormula>
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Guanosine diphosphate</bp:displayName>
 <bp:molecularWeight rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">443.02432</bp:molecularWeight>
 <bp:structure rdf:resource="#ChemicalStructure/PW_C000936" />
</bp:SmallMoleculeReference>

<bp:UnificationXref rdf:ID="Reference/HMDB_HMDB0001498">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB0001498</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/PathWhiz_PW060631">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">PW060631</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">PathWhiz</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/ChemSpider_266">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">266</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChemSpider</bp:db>
</bp:UnificationXref>

<bp:ChemicalStructure rdf:ID="ChemicalStructure/PW_C009653">
 <bp:structureFormat rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">SMILES</bp:structureFormat>
 <bp:structureData rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CC(CN(C)C)CN1C2=CC=CC=C2SC2=CC=CC=C12</bp:structureData>
</bp:ChemicalStructure>

<bp:Stoichiometry rdf:ID="Compound/PW_C001155_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#Compound/PW_C001155_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:Protein rdf:ID="Protein/2126_Endoplasmic_Reticulum">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Inositol 1,4,5-trisphosphate receptor type 1</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Endoplasmic_Reticulum" />
 <bp:entityReference rdf:resource="#ProteinReference/2126" />
</bp:Protein>

<bp:Stoichiometry rdf:ID="BoundComplex/24_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#BoundComplex/24_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:UnificationXref rdf:ID="Reference/TAXONOMY_9606">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">9606</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">TAXONOMY</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/PubChem-compound_962">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">962</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">PubChem-compound</bp:db>
</bp:UnificationXref>

<bp:Stoichiometry rdf:ID="Protein/2126_Endoplasmic_Reticulum/Stoichiometry/4.0">
 <bp:physicalEntity rdf:resource="#Protein/2126_Endoplasmic_Reticulum" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">4.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:SmallMoleculeReference rdf:ID="CompoundReference/PW_C000986">
 <bp:xref rdf:resource="#Reference/ChEBI_CHEBI_15996" />
 <bp:xref rdf:resource="#Reference/ChemSpider_6569" />
 <bp:xref rdf:resource="#Reference/KEGG_Compound_C00044" />
 <bp:xref rdf:resource="#Reference/PubChem-compound_6830" />
 <bp:xref rdf:resource="#Reference/HMDB_HMDB0001273" />
 <bp:xref rdf:resource="#Reference/CAS_86-01-1" />
 <bp:xref rdf:resource="#Reference/BioCyc_GTP" />
 <bp:chemicalFormula rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">C10H16N5O14P3</bp:chemicalFormula>
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Guanosine triphosphate</bp:displayName>
 <bp:molecularWeight rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">522.99066</bp:molecularWeight>
 <bp:structure rdf:resource="#ChemicalStructure/PW_C000986" />
</bp:SmallMoleculeReference>

<bp:SmallMolecule rdf:ID="Compound/PW_C000986_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Guanosine triphosphate</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:entityReference rdf:resource="#CompoundReference/PW_C000986" />
</bp:SmallMolecule>

<bp:UnificationXref rdf:ID="Reference/UniProt_P62873">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">P62873</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">UniProt</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/KEGG_Compound_C00076">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">C00076</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">KEGG Compound</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/ChemSpider_8630">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">8630</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChemSpider</bp:db>
</bp:UnificationXref>

<bp:ProteinReference rdf:ID="ProteinReference/1591">
 <bp:xref rdf:resource="#Reference/UniProt_P59768" />
 <bp:organism rdf:resource="#Species/1" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">G&#947;</bp:displayName>
</bp:ProteinReference>

<bp:BiochemicalPathwayStep rdf:ID="PathwayEnzymeReaction/1108457">
 <bp:stepConversion rdf:resource="#Reactions/100922" />
 <bp:stepProcess rdf:resource="#ReactionCatalysis/91035" />
</bp:BiochemicalPathwayStep>

<bp:BiochemicalPathwayStep rdf:ID="PathwayEnzymeReaction/1108458">
 <bp:stepConversion rdf:resource="#Reactions/101579" />
</bp:BiochemicalPathwayStep>

<bp:UnificationXref rdf:ID="Reference/BioCyc_CA%2b2">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CA%2b2</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">BioCyc</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/GENE_ONTOLOGY_GO_0005886">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">GO:0005886</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">GENE ONTOLOGY</bp:db>
</bp:UnificationXref>

<bp:Complex rdf:ID="BoundComplex/24_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Histamine H1 receptor (Homo sapiens)_G&#945;q (Homo sapiens)_Guanosine diphosphate_G&#946;&#947; (Homo sapiens)</bp:displayName>
 <bp:componentStoichiometry rdf:resource="#Protein/2116_Cell_Membrane/Stoichiometry/1.0" />
 <bp:componentStoichiometry rdf:resource="#ProteinComplex/6637_Cell_Membrane/Stoichiometry/1.0" />
 <bp:componentStoichiometry rdf:resource="#Compound/PW_C000936_Cell_Membrane/Stoichiometry/1.0" />
 <bp:componentStoichiometry rdf:resource="#Protein/1740_Cell_Membrane/Stoichiometry/1.0" />
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:component rdf:resource="#Compound/PW_C000936_Cell_Membrane" />
 <bp:component rdf:resource="#Protein/2116_Cell_Membrane" />
 <bp:component rdf:resource="#Protein/1740_Cell_Membrane" />
 <bp:component rdf:resource="#ProteinComplex/6637_Cell_Membrane" />
</bp:Complex>

<bp:SmallMoleculeReference rdf:ID="CompoundReference/PW_C000353">
 <bp:xref rdf:resource="#Reference/HMDB_HMDB0000464" />
 <bp:xref rdf:resource="#Reference/BioCyc_CA%2b2" />
 <bp:xref rdf:resource="#Reference/ChemSpider_266" />
 <bp:xref rdf:resource="#Reference/ChEBI_CHEBI_29108" />
 <bp:xref rdf:resource="#Reference/CAS_14127-61-8" />
 <bp:xref rdf:resource="#Reference/KEGG_Compound_C00076" />
 <bp:xref rdf:resource="#Reference/PubChem-compound_271" />
 <bp:chemicalFormula rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Ca</bp:chemicalFormula>
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Calcium</bp:displayName>
 <bp:molecularWeight rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">39.96259</bp:molecularWeight>
 <bp:structure rdf:resource="#ChemicalStructure/PW_C000353" />
</bp:SmallMoleculeReference>

<bp:SmallMolecule rdf:ID="Compound/PW_C000693_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Histamine</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:entityReference rdf:resource="#CompoundReference/PW_C000693" />
</bp:SmallMolecule>

<bp:Stoichiometry rdf:ID="Compound/Generic344_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#Compound/Generic344_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:UnificationXref rdf:ID="Reference/HMDB_HMDB0002111">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB0002111</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/BioCyc_inositol_1,4,5-trisphosphate">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">inositol_1,4,5-trisphosphate</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">BioCyc</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/CAS_84-96-8">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">84-96-8</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CAS</bp:db>
</bp:UnificationXref>

<bp:SmallMoleculeReference rdf:ID="GenericCompoundReference/295">
 <bp:xref rdf:resource="#Reference/KEGG_Compound_C00641" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">1,2-Diacyl-sn-glycerol</bp:displayName>
</bp:SmallMoleculeReference>

<bp:CellularLocationVocabulary rdf:ID="CellularLocation/Cell_Membrane">
 <bp:xref rdf:resource="#Reference/GENE_ONTOLOGY_GO_0005886" />
 <bp:term rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Cell Membrane</bp:term>
</bp:CellularLocationVocabulary>

<bp:UnificationXref rdf:ID="Reference/ChEBI_CHEBI_15377">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CHEBI:15377</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChEBI</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/UniProt_P35367">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">P35367</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">UniProt</bp:db>
</bp:UnificationXref>

<bp:SmallMolecule rdf:ID="Compound/PW_C009653_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Alimemazine</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:entityReference rdf:resource="#CompoundReference/PW_C009653" />
</bp:SmallMolecule>

<bp:UnificationXref rdf:ID="Reference/ChemSpider_6569">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">6569</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChemSpider</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/KEGG_Compound_C00001">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">C00001</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">KEGG Compound</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/BioCyc_HISTAMINE">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HISTAMINE</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">BioCyc</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/PubChem-compound_271">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">271</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">PubChem-compound</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/ChEBI_CHEBI_17552">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CHEBI:17552</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChEBI</bp:db>
</bp:UnificationXref>

<bp:ChemicalStructure rdf:ID="ChemicalStructure/PW_C000936">
 <bp:structureFormat rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">SMILES</bp:structureFormat>
 <bp:structureData rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1</bp:structureData>
</bp:ChemicalStructure>

<bp:Stoichiometry rdf:ID="BoundComplex/26_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#BoundComplex/26_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:UnificationXref rdf:ID="Reference/BioCyc_GTP">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">GTP</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">BioCyc</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/KEGG_Compound_C00641">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">C00641</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">KEGG Compound</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/ChemSpider_388562">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">388562</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChemSpider</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/HMDB_HMDB0000464">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB0000464</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/BioCyc_GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">BioCyc</bp:db>
</bp:UnificationXref>

<bp:Protein rdf:ID="Protein/1279_Cytoplasm">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Protein kinase C beta type</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Cytoplasm" />
 <bp:entityReference rdf:resource="#ProteinReference/1279" />
</bp:Protein>

<bp:SmallMolecule rdf:ID="Compound/Generic295_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">1,2-Diacyl-sn-glycerol</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:entityReference rdf:resource="#GenericCompoundReference/295" />
</bp:SmallMolecule>

<bp:UnificationXref rdf:ID="Reference/UniProt_P50148">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">P50148</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">UniProt</bp:db>
</bp:UnificationXref>

<bp:ProteinReference rdf:ID="ProteinReference/1808">
 <bp:xref rdf:resource="#Reference/UniProt_P19838" />
 <bp:organism rdf:resource="#Species/1" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Nuclear factor NF-kappa-B p105 subunit</bp:displayName>
</bp:ProteinReference>

<bp:UnificationXref rdf:ID="Reference/GENE_ONTOLOGY_GO_0005634">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">GO:0005634</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">GENE ONTOLOGY</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/HMDB_HMDB0001273">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB0001273</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB</bp:db>
</bp:UnificationXref>

<bp:PathwayStep rdf:ID="SubPathwayInteractionSteps/SubPathway53241">
 <bp:stepProcess rdf:resource="#SubPathwayInteractions/53241" />
</bp:PathwayStep>

<bp:Protein rdf:ID="Protein/216_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:entityReference rdf:resource="#ProteinReference/216" />
</bp:Protein>

<bp:Stoichiometry rdf:ID="Protein/1740_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#Protein/1740_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:Transport rdf:ID="Transports/1035">
 <bp:participantStoichiometry rdf:resource="#Compound/PW_C000353_Cytoplasm/Stoichiometry/1.0" />
 <bp:participantStoichiometry rdf:resource="#Compound/PW_C000353_Endoplasmic_Reticulum/Stoichiometry/1.0" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Transport1035</bp:displayName>
 <bp:right rdf:resource="#Compound/PW_C000353_Cytoplasm" />
 <bp:spontaneous rdf:datatype = "http://www.w3.org/2001/XMLSchema#boolean">false</bp:spontaneous>
 <bp:left rdf:resource="#Compound/PW_C000353_Endoplasmic_Reticulum" />
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Calcium (&amp;rarr;) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm</bp:name>
 <bp:conversionDirection rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">LEFT_TO_RIGHT</bp:conversionDirection>
</bp:Transport>

<bp:Stoichiometry rdf:ID="BoundComplex/27_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#BoundComplex/27_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:ChemicalStructure rdf:ID="ChemicalStructure/PW_C000986">
 <bp:structureFormat rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">SMILES</bp:structureFormat>
 <bp:structureData rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1</bp:structureData>
</bp:ChemicalStructure>

<bp:UnificationXref rdf:ID="Reference/ChEBI_CHEBI_18295">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CHEBI:18295</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChEBI</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/ChEBI_CHEBI_157833">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CHEBI:157833</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChEBI</bp:db>
</bp:UnificationXref>

<bp:Complex rdf:ID="ProteinComplex/6637_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">G&#946;&#947;</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:component rdf:resource="#Protein/3618_Cell_Membrane" />
 <bp:component rdf:resource="#Protein/1591_Cell_Membrane" />
</bp:Complex>

<bp:UnificationXref rdf:ID="Reference/HMDB_HMDB0001201">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB0001201</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/HMDB_HMDB0000870">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB0000870</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">HMDB</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/ChemSpider_753">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">753</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChemSpider</bp:db>
</bp:UnificationXref>

<bp:SmallMoleculeReference rdf:ID="CompoundReference/PW_C001420">
 <bp:xref rdf:resource="#Reference/PubChem-compound_962" />
 <bp:xref rdf:resource="#Reference/ChEBI_CHEBI_15377" />
 <bp:xref rdf:resource="#Reference/KEGG_Compound_C00001" />
 <bp:xref rdf:resource="#Reference/ChemSpider_937" />
 <bp:xref rdf:resource="#Reference/HMDB_HMDB0002111" />
 <bp:xref rdf:resource="#Reference/CAS_7732-18-5" />
 <bp:chemicalFormula rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">H2O</bp:chemicalFormula>
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Water</bp:displayName>
 <bp:molecularWeight rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">18.010565</bp:molecularWeight>
 <bp:structure rdf:resource="#ChemicalStructure/PW_C001420" />
</bp:SmallMoleculeReference>

<bp:UnificationXref rdf:ID="Reference/CAS_14127-61-8">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">14127-61-8</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CAS</bp:db>
</bp:UnificationXref>

<bp:ChemicalStructure rdf:ID="ChemicalStructure/PW_C000353">
 <bp:structureFormat rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">SMILES</bp:structureFormat>
 <bp:structureData rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">[Ca++]</bp:structureData>
</bp:ChemicalStructure>

<bp:PathwayStep rdf:ID="PathwayInteraction/240">
 <bp:stepProcess rdf:resource="#Interactions/240" />
</bp:PathwayStep>

<bp:UnificationXref rdf:ID="Reference/KEGG_Compound_C07172">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">C07172</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">KEGG Compound</bp:db>
</bp:UnificationXref>

<bp:PathwayStep rdf:ID="PathwayInteraction/241">
 <bp:stepProcess rdf:resource="#Interactions/241" />
</bp:PathwayStep>

<bp:SmallMoleculeReference rdf:ID="CompoundReference/PW_C000693">
 <bp:xref rdf:resource="#Reference/HMDB_HMDB0000870" />
 <bp:xref rdf:resource="#Reference/ChemSpider_753" />
 <bp:xref rdf:resource="#Reference/PubChem-compound_774" />
 <bp:xref rdf:resource="#Reference/BioCyc_HISTAMINE" />
 <bp:xref rdf:resource="#Reference/CAS_51-45-6" />
 <bp:xref rdf:resource="#Reference/ChEBI_CHEBI_18295" />
 <bp:xref rdf:resource="#Reference/KEGG_Compound_C00388" />
 <bp:chemicalFormula rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">C5H9N3</bp:chemicalFormula>
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Histamine</bp:displayName>
 <bp:molecularWeight rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">111.07965</bp:molecularWeight>
 <bp:structure rdf:resource="#ChemicalStructure/PW_C000693" />
</bp:SmallMoleculeReference>

<bp:PathwayStep rdf:ID="PathwayInteraction/242">
 <bp:stepProcess rdf:resource="#Interactions/242" />
</bp:PathwayStep>

<bp:PathwayStep rdf:ID="PathwayInteraction/243">
 <bp:stepProcess rdf:resource="#Interactions/243" />
</bp:PathwayStep>

<bp:SmallMolecule rdf:ID="Compound/Generic344_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">phosphatidylinositol 4,5-bisphosphate</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:entityReference rdf:resource="#GenericCompoundReference/344" />
</bp:SmallMolecule>

<bp:UnificationXref rdf:ID="Reference/CAS_86-01-1">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">86-01-1</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CAS</bp:db>
</bp:UnificationXref>

<bp:PathwayStep rdf:ID="PathwayInteraction/244">
 <bp:stepProcess rdf:resource="#Interactions/244" />
</bp:PathwayStep>

<bp:Complex rdf:ID="BoundComplex/26_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Guanosine triphosphate_G&#945;q (Homo sapiens)</bp:displayName>
 <bp:componentStoichiometry rdf:resource="#Compound/PW_C000986_Cell_Membrane/Stoichiometry/1.0" />
 <bp:componentStoichiometry rdf:resource="#Protein/1740_Cell_Membrane/Stoichiometry/1.0" />
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:component rdf:resource="#Compound/PW_C000986_Cell_Membrane" />
 <bp:component rdf:resource="#Protein/1740_Cell_Membrane" />
</bp:Complex>

<bp:PathwayStep rdf:ID="PathwayInteraction/245">
 <bp:stepProcess rdf:resource="#Interactions/245" />
</bp:PathwayStep>

<bp:CellularLocationVocabulary rdf:ID="CellularLocation/Nucleus">
 <bp:xref rdf:resource="#Reference/GENE_ONTOLOGY_GO_0005634" />
 <bp:term rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Nucleus</bp:term>
</bp:CellularLocationVocabulary>

<bp:MolecularInteraction rdf:ID="Interactions/280">
 <bp:interactionType rdf:resource="#InteractionVocabulary/direct_interaction" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Interaction280</bp:displayName>
 <bp:name rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Alimemazine inhibits Histamine + Histamine H1 receptor (Homo sapiens)</bp:name>
 <bp:participant rdf:resource="#Compound/PW_C009653_Cell_Membrane" />
 <bp:participant rdf:resource="#BoundComplex/27_Cell_Membrane" />
</bp:MolecularInteraction>

<bp:ProteinReference rdf:ID="ProteinReference/2116">
 <bp:xref rdf:resource="#Reference/UniProt_P35367" />
 <bp:organism rdf:resource="#Species/1" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Histamine H1 receptor</bp:displayName>
</bp:ProteinReference>

<bp:UnificationXref rdf:ID="Reference/ChEBI_CHEBI_15996">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CHEBI:15996</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChEBI</bp:db>
</bp:UnificationXref>

<bp:Stoichiometry rdf:ID="Compound/Generic295_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#Compound/Generic295_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:Protein rdf:ID="Protein/3618_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">G&#946;</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:entityReference rdf:resource="#ProteinReference/3618" />
</bp:Protein>

<bp:SmallMolecule rdf:ID="Compound/PW_C000353_Endoplasmic_Reticulum">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Calcium</bp:displayName>
 <bp:cellularLocation rdf:resource="#CellularLocation/Endoplasmic_Reticulum" />
 <bp:entityReference rdf:resource="#CompoundReference/PW_C000353" />
</bp:SmallMolecule>

<bp:Complex rdf:ID="ProteinComplex/270_Endoplasmic_Reticulum">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Inositol 1,4,5-trisphosphate receptor type 1</bp:displayName>
 <bp:componentStoichiometry rdf:resource="#Protein/2126_Endoplasmic_Reticulum/Stoichiometry/4.0" />
 <bp:cellularLocation rdf:resource="#CellularLocation/Endoplasmic_Reticulum" />
 <bp:component rdf:resource="#Protein/2126_Endoplasmic_Reticulum" />
</bp:Complex>

<bp:UnificationXref rdf:ID="Reference/ChemSpider_5373">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">5373</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChemSpider</bp:db>
</bp:UnificationXref>

<bp:Stoichiometry rdf:ID="Compound/PW_C000353_Endoplasmic_Reticulum/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#Compound/PW_C000353_Endoplasmic_Reticulum" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:UnificationXref rdf:ID="Reference/KEGG_Compound_C00388">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">C00388</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">KEGG Compound</bp:db>
</bp:UnificationXref>

<bp:SmallMoleculeReference rdf:ID="CompoundReference/PW_C001155">
 <bp:xref rdf:resource="#Reference/HMDB_HMDB0001498" />
 <bp:xref rdf:resource="#Reference/PubChem-compound_439456" />
 <bp:xref rdf:resource="#Reference/CAS_85166-31-0" />
 <bp:xref rdf:resource="#Reference/BioCyc_inositol_1,4,5-trisphosphate" />
 <bp:xref rdf:resource="#Reference/KEGG_Compound_C01245" />
 <bp:xref rdf:resource="#Reference/ChEBI_CHEBI_16595" />
 <bp:xref rdf:resource="#Reference/ChemSpider_388562" />
 <bp:chemicalFormula rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">C6H15O15P3</bp:chemicalFormula>
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Inositol 1,4,5-trisphosphate</bp:displayName>
 <bp:molecularWeight rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">419.96237</bp:molecularWeight>
 <bp:structure rdf:resource="#ChemicalStructure/PW_C001155" />
</bp:SmallMoleculeReference>

<bp:BiochemicalPathwayStep rdf:ID="PathwayTransport/1108459">
 <bp:stepConversion rdf:resource="#Transports/1035" />
 <bp:stepProcess rdf:resource="#TransportCatalysis/922" />
</bp:BiochemicalPathwayStep>

<bp:Stoichiometry rdf:ID="Compound/PW_C000936_Cell_Membrane/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#Compound/PW_C000936_Cell_Membrane" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:UnificationXref rdf:ID="Reference/ChEBI_CHEBI_29108">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CHEBI:29108</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">ChEBI</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/GENE_ONTOLOGY_GO_0005737">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">GO:0005737</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">GENE ONTOLOGY</bp:db>
</bp:UnificationXref>

<bp:UnificationXref rdf:ID="Reference/CAS_146-91-8">
 <bp:id rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">146-91-8</bp:id>
 <bp:db rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">CAS</bp:db>
</bp:UnificationXref>

<bp:Complex rdf:ID="BoundComplex/27_Cell_Membrane">
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">Histamine_Histamine H1 receptor (Homo sapiens)</bp:displayName>
 <bp:componentStoichiometry rdf:resource="#Protein/2116_Cell_Membrane/Stoichiometry/1.0" />
 <bp:componentStoichiometry rdf:resource="#Compound/PW_C000693_Cell_Membrane/Stoichiometry/1.0" />
 <bp:cellularLocation rdf:resource="#CellularLocation/Cell_Membrane" />
 <bp:component rdf:resource="#Protein/2116_Cell_Membrane" />
 <bp:component rdf:resource="#Compound/PW_C000693_Cell_Membrane" />
</bp:Complex>

<bp:Stoichiometry rdf:ID="Compound/PW_C000353_Cytoplasm/Stoichiometry/1.0">
 <bp:physicalEntity rdf:resource="#Compound/PW_C000353_Cytoplasm" />
 <bp:stoichiometricCoefficient rdf:datatype = "http://www.w3.org/2001/XMLSchema#float">1.0</bp:stoichiometricCoefficient>
</bp:Stoichiometry>

<bp:SmallMoleculeReference rdf:ID="GenericCompoundReference/344">
 <bp:xref rdf:resource="#Reference/KEGG_Compound_C04637" />
 <bp:displayName rdf:datatype = "http://www.w3.org/2001/XMLSchema#string">phosphatidylinositol 4,5-bisphosphate</bp:displayName>
</bp:SmallMoleculeReference>
</rdf:RDF>