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<super-pathway-visualization>
  <named-for-id type="integer">60479</named-for-id>
  <named-for-type>Pathway</named-for-type>
  <cached-name>Alimemazine H1-Antihistamine Action</cached-name>
  <cached-description>Alimemazine (trimeprazine) is a first-generation phenothiazine H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. Furthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release. First-generation antihistamines readily cross the blood-brain barrier and cause sedation and other adverse central nervous system (CNS) effects (e.g. nervousness and insomnia). Second-generation antihistamines are more selective for H1-receptors of the peripheral nervous system (PNS) and do not cross the blood-brain barrier. Consequently, these newer drugs elicit fewer adverse drug reactions.</cached-description>
  <cached-subject>Drug Action</cached-subject>
  <pw-id>PW060631</pw-id>
  <pathway-visualization-contexts>
    <pathway-visualization-context>
      <position>Center</position>
      <id>PathwayVisualizationContext60909</id>
      <pathway-visualization>
        <height type="integer">1288</height>
        <width type="integer">2350</width>
        <background-color>#FFFFFF</background-color>
        <id>PathwayVisualization60379</id>
        <pathway>
          <id type="integer">60479</id>
          <name>Alimemazine H1-Antihistamine Action</name>
          <description>Alimemazine (trimeprazine) is a first-generation phenothiazine H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. Furthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release. First-generation antihistamines readily cross the blood-brain barrier and cause sedation and other adverse central nervous system (CNS) effects (e.g. nervousness and insomnia). Second-generation antihistamines are more selective for H1-receptors of the peripheral nervous system (PNS) and do not cross the blood-brain barrier. Consequently, these newer drugs elicit fewer adverse drug reactions.</description>
          <subject>Drug</subject>
          <species-id type="integer">1</species-id>
          <sub-pathways>
            <sub-pathway>
              <id type="integer">53241</id>
              <reference-pathway-id type="integer" nil="true"/>
              <altext>Mast Cells Release Histamine</altext>
              <sub-pathway-type>SubPathway</sub-pathway-type>
              <sub-pathway-outputs>
                <sub-pathway-output>
                  <id type="integer">51079</id>
                  <element-id type="integer">693</element-id>
                  <element-type>Compound</element-type>
                  <biological-state-id type="integer">1</biological-state-id>
                </sub-pathway-output>
              </sub-pathway-outputs>
            </sub-pathway>
          </sub-pathways>
          <references>
            <reference>
              <id type="integer">211064</id>
              <pubmed-id>22035879</pubmed-id>
              <text>Simons FE, Simons KJ: Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol. 2011 Dec;128(6):1139-1150.e4. doi: 10.1016/j.jaci.2011.09.005. Epub 2011 Oct 27.</text>
              <element-id type="integer">60479</element-id>
              <element-type>Pathway</element-type>
            </reference>
          </references>
          <references>
            <reference>
              <id type="integer">211065</id>
              <pubmed-id>7913608</pubmed-id>
              <text>Simons FE: H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994 May;10(5):350-80.</text>
              <element-id type="integer">60479</element-id>
              <element-type>Pathway</element-type>
            </reference>
          </references>
          <references>
            <reference>
              <id type="integer">211066</id>
              <pubmed-id>2174351</pubmed-id>
              <text>Mignery GA, Sudhof TC: The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor. EMBO J. 1990 Dec;9(12):3893-8.</text>
              <element-id type="integer">60479</element-id>
              <element-type>Pathway</element-type>
            </reference>
          </references>
        </pathway>
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            <name>Cell</name>
            <ontology-id>CL:0000000</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">5</id>
            <name>Hepatocyte</name>
            <ontology-id>CL:0000182</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">4</id>
            <name>Cardiomyocyte </name>
            <ontology-id>CL:0000746</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">3</id>
            <name>Neuron</name>
            <ontology-id>CL:0000540</ontology-id>
          </cell-type>
          <cell-type>
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            <name>Epithelial Cell</name>
            <ontology-id>CL:0000066</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">2</id>
            <name>Platelet </name>
            <ontology-id>CL:0000233</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">8</id>
            <name>Beta cell</name>
            <ontology-id>CL:0000639</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">6</id>
            <name>Myocyte</name>
            <ontology-id>CL:0000187</ontology-id>
          </cell-type>
          <cell-type>
            <id type="integer">14</id>
            <name>Parietal Cell</name>
            <ontology-id>CL:0000162</ontology-id>
          </cell-type>
        </cell-types>
        <species>
          <species>
            <id type="integer">1</id>
            <name>Homo sapiens</name>
            <taxonomy-id>9606</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Human</common-name>
          </species>
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            <id type="integer">2</id>
            <name>Bacteria</name>
            <taxonomy-id>2</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name>Bacteria</common-name>
          </species>
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            <id type="integer">3</id>
            <name>Escherichia coli</name>
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            <classification>Prokaryote</classification>
            <common-name></common-name>
          </species>
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            <id type="integer">12</id>
            <name>Mus musculus</name>
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            <classification>Eukaryote</classification>
            <common-name>Mouse</common-name>
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            <name>Bos taurus</name>
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            <classification>Eukaryote</classification>
            <common-name>Cattle</common-name>
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            <name>Rattus norvegicus</name>
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            <classification>Eukaryote</classification>
            <common-name>Rat</common-name>
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            <name>Schizosaccharomyces pombe</name>
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            <classification>Eukaryote</classification>
            <common-name></common-name>
          </species>
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            <id type="integer">24</id>
            <name>Solanum lycopersicum</name>
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            <classification>Eukaryote</classification>
            <common-name>Tomato</common-name>
          </species>
          <species>
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            <name>Arabidopsis thaliana</name>
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            <classification>Eukaryote</classification>
            <common-name>Thale cress</common-name>
          </species>
          <species>
            <id type="integer">18</id>
            <name>Saccharomyces cerevisiae</name>
            <taxonomy-id>4932</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Yeast</common-name>
          </species>
          <species>
            <id type="integer">21</id>
            <name>Xenopus laevis</name>
            <taxonomy-id>8355</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>African clawed frog</common-name>
          </species>
          <species>
            <id type="integer">6</id>
            <name>Caenorhabditis elegans</name>
            <taxonomy-id>6239</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Roundworm</common-name>
          </species>
          <species>
            <id type="integer">25</id>
            <name>Escherichia coli (strain K12)</name>
            <taxonomy-id>83333</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
          </species>
          <species>
            <id type="integer">49</id>
            <name>Bathymodiolus platifrons</name>
            <taxonomy-id>220390</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Deep sea mussel</common-name>
          </species>
          <species>
            <id type="integer">10</id>
            <name>Drosophila melanogaster</name>
            <taxonomy-id>7227</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Fruit fly</common-name>
          </species>
          <species>
            <id type="integer">23</id>
            <name>Pseudomonas aeruginosa</name>
            <taxonomy-id>287</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name></common-name>
          </species>
          <species>
            <id type="integer">60</id>
            <name>Nitzschia sp.</name>
            <taxonomy-id>0001</taxonomy-id>
            <classification>Eukaryote</classification>
            <common-name>Nitzschia4</common-name>
          </species>
          <species>
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            <name>Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)</name>
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            <classification>Prokaryote</classification>
            <common-name nil="true"/>
          </species>
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            <name>Andro</name>
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            <classification>Eukaryote</classification>
            <common-name nil="true"/>
          </species>
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            <name>Acinetobacter baumannii </name>
            <taxonomy-id>107673</taxonomy-id>
            <classification>Prokaryote</classification>
            <common-name nil="true"/>
          </species>
        </species>
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            <name>Cytoplasm</name>
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            <name>Lysosome</name>
            <ontology-id>GO:0005764</ontology-id>
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            <ontology-id>GO:0005777</ontology-id>
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            <name>Mitochondrial Matrix</name>
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            <name>Mitochondrion</name>
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            <name>Extracellular Space</name>
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            <name>Endoplasmic Reticulum Membrane</name>
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            <name>Melanosome Membrane</name>
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            <name>Mitochondrial Inner Membrane</name>
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            <name>Endocytic Vesicle</name>
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          <biological-state>
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          <biological-state>
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          <biological-state>
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            <subcellular-location-id type="integer">15</subcellular-location-id>
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          <biological-state>
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          <biological-state>
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          <biological-state>
            <id type="integer">516</id>
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          <biological-state>
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          </biological-state>
          <biological-state>
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          <biological-state>
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          </biological-state>
          <biological-state>
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          </biological-state>
          <biological-state>
            <id type="integer">71</id>
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            <subcellular-location-id type="integer">11</subcellular-location-id>
            <species-id type="integer">1</species-id>
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          <biological-state>
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            <tissue-id type="integer">18</tissue-id>
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          <biological-state>
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          <biological-state>
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          <biological-state>
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          <biological-state>
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          <biological-state>
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            <subcellular-location-id type="integer">37</subcellular-location-id>
            <species-id type="integer">1</species-id>
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          <biological-state>
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            <species-id type="integer">1</species-id>
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          <biological-state>
            <id type="integer">787</id>
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            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">3</cell-type-id>
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          <biological-state>
            <id type="integer">898</id>
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            <subcellular-location-id type="integer">37</subcellular-location-id>
            <species-id type="integer">157</species-id>
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          <biological-state>
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            <tissue-id type="integer">28</tissue-id>
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            <species-id type="integer">157</species-id>
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          <biological-state>
            <id type="integer">204</id>
            <tissue-id type="integer">7</tissue-id>
            <subcellular-location-id type="integer">33</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">3</cell-type-id>
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          <biological-state>
            <id type="integer">804</id>
            <tissue-id type="integer">7</tissue-id>
            <subcellular-location-id type="integer">33</subcellular-location-id>
            <species-id type="integer">157</species-id>
            <cell-type-id type="integer">3</cell-type-id>
            <pwbs-id>PW_BS000548</pwbs-id>
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          <biological-state>
            <id type="integer">654</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">13</subcellular-location-id>
            <species-id type="integer">62</species-id>
            <cell-type-id type="integer">1</cell-type-id>
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          <biological-state>
            <id type="integer">870</id>
            <tissue-id type="integer" nil="true"/>
            <subcellular-location-id type="integer">54</subcellular-location-id>
            <species-id type="integer">1</species-id>
            <cell-type-id type="integer">3</cell-type-id>
            <pwbs-id>PW_BS000552</pwbs-id>
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        </biological-states>
        <bounds>
          <bound>
            <id type="integer">24</id>
            <pwb-id>PW_B000024</pwb-id>
            <bound-elements>
              <bound-element>
                <id type="integer">56</id>
                <element-id type="integer">6635</element-id>
                <element-type>ProteinComplex</element-type>
                <stoichiometry type="integer">1</stoichiometry>
              </bound-element>
              <bound-element>
                <id type="integer">57</id>
                <element-id type="integer">6636</element-id>
                <element-type>ProteinComplex</element-type>
                <stoichiometry type="integer">1</stoichiometry>
              </bound-element>
              <bound-element>
                <id type="integer">58</id>
                <element-id type="integer">936</element-id>
                <element-type>Compound</element-type>
                <stoichiometry type="integer">1</stoichiometry>
              </bound-element>
              <bound-element>
                <id type="integer">59</id>
                <element-id type="integer">6637</element-id>
                <element-type>ProteinComplex</element-type>
                <stoichiometry type="integer">1</stoichiometry>
              </bound-element>
            </bound-elements>
            <element-states>
              <element-state>
                <id type="integer">69312</id>
                <biological-state-id type="integer">308</biological-state-id>
              </element-state>
            </element-states>
          </bound>
          <bound>
            <id type="integer">26</id>
            <pwb-id>PW_B000026</pwb-id>
            <bound-elements>
              <bound-element>
                <id type="integer">63</id>
                <element-id type="integer">986</element-id>
                <element-type>Compound</element-type>
                <stoichiometry type="integer">1</stoichiometry>
              </bound-element>
              <bound-element>
                <id type="integer">64</id>
                <element-id type="integer">6636</element-id>
                <element-type>ProteinComplex</element-type>
                <stoichiometry type="integer">1</stoichiometry>
              </bound-element>
            </bound-elements>
            <element-states>
              <element-state>
                <id type="integer">69318</id>
                <biological-state-id type="integer">8</biological-state-id>
              </element-state>
            </element-states>
          </bound>
          <bound>
            <id type="integer">27</id>
            <pwb-id>PW_B000027</pwb-id>
            <bound-elements>
              <bound-element>
                <id type="integer">65</id>
                <element-id type="integer">693</element-id>
                <element-type>Compound</element-type>
                <stoichiometry type="integer">1</stoichiometry>
              </bound-element>
              <bound-element>
                <id type="integer">66</id>
                <element-id type="integer">6635</element-id>
                <element-type>ProteinComplex</element-type>
                <stoichiometry type="integer">1</stoichiometry>
              </bound-element>
            </bound-elements>
            <element-states>
              <element-state>
                <id type="integer">70003</id>
                <biological-state-id type="integer">308</biological-state-id>
              </element-state>
            </element-states>
          </bound>
        </bounds>
        <compounds>
          <compound>
            <id type="integer">936</id>
            <name>Guanosine diphosphate</name>
            <hmdb-id>HMDB0001201</hmdb-id>
            <description>Guanosine 5'-(trihydrogen diphosphate). A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. It is an ester of pyrophosphoric acid with the nucleoside guanosine. GDP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase guanine. GDP is the product of GTP dephosphorylation by GTPases, e.g. the G-proteins that are involved in signal transduction.</description>
            <cas>146-91-8</cas>
            <kegg-id>C00035</kegg-id>
            <pubchem-cid>8977</pubchem-cid>
            <chebi-id>17552</chebi-id>
            <biocyc-id>GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE</biocyc-id>
            <chemspider-id>8630</chemspider-id>
            <drugbank-id nil="true"/>
            <moldb-smiles>NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1</moldb-smiles>
            <moldb-formula>C10H15N5O11P2</moldb-formula>
            <moldb-inchi>InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1</moldb-inchi>
            <moldb-inchikey>QGWNDRXFNXRZMB-UUOKFMHZSA-N</moldb-inchikey>
            <moldb-iupac>[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid</moldb-iupac>
            <moldb-average-mass>443.2005</moldb-average-mass>
            <moldb-mono-mass>443.024329371</moldb-mono-mass>
            <moldb-alogps-logs>-2.00</moldb-alogps-logs>
            <moldb-donor-count>7</moldb-donor-count>
            <moldb-traditional-iupac>{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxyphosphonic acid</moldb-traditional-iupac>
            <moldb-formal-charge type="integer">0</moldb-formal-charge>
            <moldb-physiological-charge type="integer">-3</moldb-physiological-charge>
            <drugbank-metabolite-id nil="true"/>
            <foodb-id>FDB022487</foodb-id>
            <synonyms>5'-gdp;Gdp;Guanosine 5'-(trihydrogen pyrophosphate);Guanosine 5'-diphosphate;Guanosine 5'-pyrophosphate;Guanosine mono(trihydrogen diphosphate);Guanosine pyrophosphate;Guanosine-5'-diphosphate;Guanosine-diphosphate;Ppg;Guanosine diphosphate;Guanosine 5'-diphosphoric acid</synonyms>
            <pwc-id>PW_C000936</pwc-id>
            <short-name>GDP</short-name>
            <element-states>
              <element-state>
                <id type="integer">83</id>
                <biological-state-id type="integer">8</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">238</id>
                <biological-state-id type="integer">4</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">1762</id>
                <biological-state-id type="integer">14</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">2391</id>
                <biological-state-id type="integer">2</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">4154</id>
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                <biological-state-id type="integer">222</biological-state-id>
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                <biological-state-id type="integer">115</biological-state-id>
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                <id type="integer">11771</id>
                <biological-state-id type="integer">211</biological-state-id>
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                <biological-state-id type="integer">198</biological-state-id>
              </element-state>
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                <id type="integer">12727</id>
                <biological-state-id type="integer">290</biological-state-id>
              </element-state>
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                <id type="integer">13395</id>
                <biological-state-id type="integer">151</biological-state-id>
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                <id type="integer">69322</id>
                <biological-state-id type="integer">1</biological-state-id>
              </element-state>
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                <id type="integer">77142</id>
                <biological-state-id type="integer">133</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">77546</id>
                <biological-state-id type="integer">111</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">77952</id>
                <biological-state-id type="integer">132</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">80023</id>
                <biological-state-id type="integer">368</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">80080</id>
                <biological-state-id type="integer">308</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">80122</id>
                <biological-state-id type="integer">164</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">89115</id>
                <biological-state-id type="integer">253</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">119983</id>
                <biological-state-id type="integer">406</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">120068</id>
                <biological-state-id type="integer">122</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">121205</id>
                <biological-state-id type="integer">124</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">121847</id>
                <biological-state-id type="integer">405</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">122766</id>
                <biological-state-id type="integer">120</biological-state-id>
              </element-state>
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                <id type="integer">122820</id>
                <biological-state-id type="integer">135</biological-state-id>
              </element-state>
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                <id type="integer">123775</id>
                <biological-state-id type="integer">118</biological-state-id>
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                <id type="integer">124400</id>
                <biological-state-id type="integer">376</biological-state-id>
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                <id type="integer">125363</id>
                <biological-state-id type="integer">479</biological-state-id>
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                <id type="integer">125445</id>
                <biological-state-id type="integer">297</biological-state-id>
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                <id type="integer">126905</id>
                <biological-state-id type="integer">501</biological-state-id>
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                <id type="integer">126984</id>
                <biological-state-id type="integer">205</biological-state-id>
              </element-state>
            </element-states>
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            <id type="integer">986</id>
            <name>Guanosine triphosphate</name>
            <hmdb-id>HMDB0001273</hmdb-id>
            <description>Guanosine triphosphate (GTP) is a guanine nucleotide containing three phosphate groups esterified to the sugar moiety. GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.</description>
            <cas>86-01-1</cas>
            <kegg-id>C00044</kegg-id>
            <pubchem-cid>6830</pubchem-cid>
            <chebi-id>15996</chebi-id>
            <biocyc-id>GTP</biocyc-id>
            <chemspider-id>6569</chemspider-id>
            <drugbank-id nil="true"/>
            <moldb-smiles>NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1</moldb-smiles>
            <moldb-formula>C10H16N5O14P3</moldb-formula>
            <moldb-inchi>InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1</moldb-inchi>
            <moldb-inchikey>XKMLYUALXHKNFT-UUOKFMHZSA-N</moldb-inchikey>
            <moldb-iupac>({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid</moldb-iupac>
            <moldb-average-mass>523.1804</moldb-average-mass>
            <moldb-mono-mass>522.990659781</moldb-mono-mass>
            <moldb-alogps-logs>-1.70</moldb-alogps-logs>
            <moldb-donor-count>8</moldb-donor-count>
            <moldb-traditional-iupac>triphosphate, guanosine</moldb-traditional-iupac>
            <moldb-formal-charge type="integer">0</moldb-formal-charge>
            <moldb-physiological-charge type="integer">-3</moldb-physiological-charge>
            <drugbank-metabolite-id nil="true"/>
            <foodb-id>FDB022527</foodb-id>
            <synonyms>5'-gtp;Gtg;Gtp;Guanosine 5'-(tetrahydrogen triphosphate);Guanosine 5'-triphosphate;Guanosine 5'-triphosphorate;Guanosine 5'-triphosphoric acid;Guanosine triphosphate;Guanosine mono(tetrahydrogen triphosphate) (ester);H4gtp;Guanosine-5'-triphosphate</synonyms>
            <pwc-id>PW_C000986</pwc-id>
            <short-name>GTP</short-name>
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                <id type="integer">81</id>
                <biological-state-id type="integer">8</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">240</id>
                <biological-state-id type="integer">4</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">1939</id>
                <biological-state-id type="integer">2</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">4091</id>
                <biological-state-id type="integer">14</biological-state-id>
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                <id type="integer">4153</id>
                <biological-state-id type="integer">73</biological-state-id>
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              <element-state>
                <id type="integer">5006</id>
                <biological-state-id type="integer">85</biological-state-id>
              </element-state>
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                <id type="integer">5384</id>
                <biological-state-id type="integer">103</biological-state-id>
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              <element-state>
                <id type="integer">6043</id>
                <biological-state-id type="integer">155</biological-state-id>
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              <element-state>
                <id type="integer">6103</id>
                <biological-state-id type="integer">161</biological-state-id>
              </element-state>
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                <id type="integer">6490</id>
                <biological-state-id type="integer">178</biological-state-id>
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                <id type="integer">7478</id>
                <biological-state-id type="integer">222</biological-state-id>
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              <element-state>
                <id type="integer">11753</id>
                <biological-state-id type="integer">115</biological-state-id>
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              <element-state>
                <id type="integer">11769</id>
                <biological-state-id type="integer">198</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">11981</id>
                <biological-state-id type="integer">151</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">12725</id>
                <biological-state-id type="integer">290</biological-state-id>
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              <element-state>
                <id type="integer">69327</id>
                <biological-state-id type="integer">1</biological-state-id>
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              <element-state>
                <id type="integer">76962</id>
                <biological-state-id type="integer">225</biological-state-id>
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                <id type="integer">77144</id>
                <biological-state-id type="integer">133</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">77544</id>
                <biological-state-id type="integer">111</biological-state-id>
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              <element-state>
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                <biological-state-id type="integer">132</biological-state-id>
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                <id type="integer">80025</id>
                <biological-state-id type="integer">368</biological-state-id>
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              <element-state>
                <id type="integer">80088</id>
                <biological-state-id type="integer">308</biological-state-id>
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              <element-state>
                <id type="integer">80121</id>
                <biological-state-id type="integer">164</biological-state-id>
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              <element-state>
                <id type="integer">89113</id>
                <biological-state-id type="integer">253</biological-state-id>
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                <id type="integer">119985</id>
                <biological-state-id type="integer">406</biological-state-id>
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                <id type="integer">120066</id>
                <biological-state-id type="integer">122</biological-state-id>
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                <id type="integer">121204</id>
                <biological-state-id type="integer">124</biological-state-id>
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                <id type="integer">122768</id>
                <biological-state-id type="integer">120</biological-state-id>
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                <id type="integer">122818</id>
                <biological-state-id type="integer">135</biological-state-id>
              </element-state>
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                <id type="integer">123774</id>
                <biological-state-id type="integer">118</biological-state-id>
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                <id type="integer">125365</id>
                <biological-state-id type="integer">479</biological-state-id>
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                <id type="integer">125443</id>
                <biological-state-id type="integer">297</biological-state-id>
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                <id type="integer">126480</id>
                <biological-state-id type="integer">299</biological-state-id>
              </element-state>
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                <id type="integer">126907</id>
                <biological-state-id type="integer">501</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">126982</id>
                <biological-state-id type="integer">205</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">128051</id>
                <biological-state-id type="integer">388</biological-state-id>
              </element-state>
            </element-states>
          </compound>
          <compound>
            <id type="integer">693</id>
            <name>Histamine</name>
            <hmdb-id>HMDB0000870</hmdb-id>
            <description>Histamine, also known as eramin or ceplene, belongs to the class of organic compounds known as 2-arylethylamines. These are primary amines that have the general formula RCCNH2, where R is an organic group. Histamine exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). Histamine has been found throughout most human tissues, and has also been detected in most biofluids, including feces, saliva, urine, and blood. Within the cell, histamine is primarily located in the myelin sheath. In humans, histamine is involved in the phenbenzamine H1-antihistamine action pathway, the omeprazole action pathway, the levocetirizine H1-antihistamine action pathway, and the propiomazine H1-antihistamine action pathway. Histamine is also involved in several metabolic disorders, some of which include the thiazinamium H1-antihistamine action pathway, the metiamide action pathway, the quetiapine H1-antihistamine action pathway, and the histidinemia pathway. Outside of the human body, histamine can be found in a number of food items such as daikon radish, jicama, caraway, and japanese walnut. This makes histamine a potential biomarker for the consumption of these food products. Histamine is an amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.</description>
            <cas>51-45-6</cas>
            <kegg-id>C00388</kegg-id>
            <pubchem-cid>774</pubchem-cid>
            <chebi-id>18295</chebi-id>
            <biocyc-id>HISTAMINE</biocyc-id>
            <chemspider-id>753</chemspider-id>
            <drugbank-id nil="true"/>
            <moldb-smiles>NCCC1=CNC=N1</moldb-smiles>
            <moldb-formula>C5H9N3</moldb-formula>
            <moldb-inchi>InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)</moldb-inchi>
            <moldb-inchikey>NTYJJOPFIAHURM-UHFFFAOYSA-N</moldb-inchikey>
            <moldb-iupac>2-(1H-imidazol-4-yl)ethan-1-amine</moldb-iupac>
            <moldb-average-mass>111.1451</moldb-average-mass>
            <moldb-mono-mass>111.079647303</moldb-mono-mass>
            <moldb-alogps-logs>0.18</moldb-alogps-logs>
            <moldb-donor-count>2</moldb-donor-count>
            <moldb-traditional-iupac>histamine</moldb-traditional-iupac>
            <moldb-formal-charge type="integer">0</moldb-formal-charge>
            <moldb-physiological-charge type="integer">1</moldb-physiological-charge>
            <drugbank-metabolite-id nil="true"/>
            <foodb-id>FDB012596</foodb-id>
            <synonyms>1h-imidazole-4-ethanamine;2-(1h-imidazol-4-yl)ethanamine;2-(1h-imidazol-4-yl)ethylamine;2-(1h-imidazol-5-yl)ethanamine;2-(1h-imidazol-5-yl)ethylamine;2-(4-imidazolyl)ethanamine;2-(4-imidazolyl)ethylamine;2-imidazol-4-yl-ethylamine;2-imidazol-4-ylethylamine;4-(2-aminoethyl)-1h-imidazole;4-(2-aminoethyl)imidazole;4-imidazoleethylamine;5-imidazoleethylamine;Eramin;Ergamine;Ergotidine;Free histamine;Hsm;Histamine;L-histamin base;L-histamine;Theramine;B-imidazolyl-4-ethylamine;Beta-aminoethylglyoxaline;Beta-aminoethylimidazole;Beta-aminothethylglyoxaline;Beta-imidazolyl-4-ethylamine</synonyms>
            <pwc-id>PW_C000693</pwc-id>
            <short-name>Hsm</short-name>
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              <element-state>
                <id type="integer">1310</id>
                <biological-state-id type="integer">8</biological-state-id>
              </element-state>
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                <id type="integer">3153</id>
                <biological-state-id type="integer">14</biological-state-id>
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              <element-state>
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              <element-state>
                <id type="integer">4159</id>
                <biological-state-id type="integer">2</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">67311</id>
                <biological-state-id type="integer">1</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">70008</id>
                <biological-state-id type="integer">308</biological-state-id>
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              <element-state>
                <id type="integer">78132</id>
                <biological-state-id type="integer">111</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">121026</id>
                <biological-state-id type="integer">122</biological-state-id>
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                <id type="integer">123591</id>
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            <name>Water</name>
            <hmdb-id>HMDB0002111</hmdb-id>
            <description>Water is a chemical substance that is essential to all known forms of life. It appears colorless to the naked eye in small quantities, though it is actually slightly blue in color. It covers 71% of Earth's surface. Current estimates suggest that there are 1.4 billion cubic kilometers (330 million m3) of it available on Earth, and it exists in many forms. It appears mostly in the oceans (saltwater) and polar ice caps, but it is also present as clouds, rain water, rivers, freshwater aquifers, lakes, and sea ice. Water in these bodies perpetually moves through a cycle of evaporation, precipitation, and runoff to the sea. Clean water is essential to human life. In many parts of the world, it is in short supply. From a biological standpoint, water has many distinct properties that are critical for the proliferation of life that set it apart from other substances. It carries out this role by allowing organic compounds to react in ways that ultimately allow replication. All known forms of life depend on water. Water is vital both as a solvent in which many of the body's solutes dissolve and as an essential part of many metabolic processes within the body. Metabolism is the sum total of anabolism and catabolism. In anabolism, water is removed from molecules (through energy requiring enzymatic chemical reactions) in order to grow larger molecules (e.g. starches, triglycerides and proteins for storage of fuels and information). In catabolism, water is used to break bonds in order to generate smaller molecules (e.g. glucose, fatty acids and amino acids to be used for fuels for energy use or other purposes). Water is thus essential and central to these metabolic processes. Water is also central to photosynthesis and respiration. Photosynthetic cells use the sun's energy to split off water's hydrogen from oxygen. Hydrogen is combined with CO2 (absorbed from air or water) to form glucose and release oxygen. All living cells use such fuels and oxidize the hydrogen and carbon to capture the sun's energy and reform water and CO2 in the process (cellular respiration). Water is also central to acid-base neutrality and enzyme function. An acid, a hydrogen ion (H+, that is, a proton) donor, can be neutralized by a base, a proton acceptor such as hydroxide ion (OH-) to form water. Water is considered to be neutral, with a pH (the negative log of the hydrogen ion concentration) of 7. Acids have pH values less than 7 while bases have values greater than 7. Stomach acid (HCl) is useful to digestion. However, its corrosive effect on the esophagus during reflux can temporarily be neutralized by ingestion of a base such as aluminum hydroxide to produce the neutral molecules water and the salt aluminum chloride. Human biochemistry that involves enzymes usually performs optimally around a biologically neutral pH of 7.4. (Wikipedia).</description>
            <cas>7732-18-5</cas>
            <kegg-id>C00001</kegg-id>
            <pubchem-cid>962</pubchem-cid>
            <chebi-id>15377</chebi-id>
            <biocyc-id nil="true"/>
            <chemspider-id>937</chemspider-id>
            <drugbank-id nil="true"/>
            <moldb-smiles>O</moldb-smiles>
            <moldb-formula>H2O</moldb-formula>
            <moldb-inchi>InChI=1S/H2O/h1H2</moldb-inchi>
            <moldb-inchikey>XLYOFNOQVPJJNP-UHFFFAOYSA-N</moldb-inchikey>
            <moldb-iupac>water</moldb-iupac>
            <moldb-average-mass>18.0153</moldb-average-mass>
            <moldb-mono-mass>18.010564686</moldb-mono-mass>
            <moldb-alogps-logs nil="true"/>
            <moldb-donor-count>1</moldb-donor-count>
            <moldb-traditional-iupac>water</moldb-traditional-iupac>
            <moldb-formal-charge type="integer">0</moldb-formal-charge>
            <moldb-physiological-charge type="integer">0</moldb-physiological-charge>
            <drugbank-metabolite-id nil="true"/>
            <foodb-id>FDB013390</foodb-id>
            <synonyms>Dihydrogen oxide;Steam;[oh2];Acqua;Agua;Aqua;Bound water;Dihydridooxygen;Eau;H2o;Hoh;Hydrogen hydroxide;Wasser</synonyms>
            <pwc-id>PW_C001420</pwc-id>
            <short-name>H2O</short-name>
            <element-states>
              <element-state>
                <id type="integer">55</id>
                <biological-state-id type="integer">8</biological-state-id>
              </element-state>
              <element-state>
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                <biological-state-id type="integer">9</biological-state-id>
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              <element-state>
                <id type="integer">109</id>
                <biological-state-id type="integer">5</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">139</id>
                <biological-state-id type="integer">4</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">151</id>
                <biological-state-id type="integer">3</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">162</id>
                <biological-state-id type="integer">14</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">481</id>
                <biological-state-id type="integer">13</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">526</id>
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            <name>Inositol 1,4,5-trisphosphate</name>
            <hmdb-id>HMDB0001498</hmdb-id>
            <description>Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. (PubChem). Inositol 1,4,5-trisphosphate (InsP3) is traditionally considered to be the messenger that initiates the increase and spreading of the activating Ca2+ wave. In line with this hypothesis, recent evidence suggests that the penetrating sperm delivers into mammalian eggs a novel isoform of phospholipase C (PLC), which promotes the formation of InsP3. The mechanism by which the interacting sperm triggers the production of NAADP and subsequently that of InsP3 remains obscure. (PMID: 15362223).</description>
            <cas>85166-31-0</cas>
            <kegg-id>C01245</kegg-id>
            <pubchem-cid>439456</pubchem-cid>
            <chebi-id>16595</chebi-id>
            <biocyc-id>inositol_1,4,5-trisphosphate</biocyc-id>
            <chemspider-id>388562</chemspider-id>
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            <moldb-smiles>O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O</moldb-smiles>
            <moldb-formula>C6H15O15P3</moldb-formula>
            <moldb-inchi>InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/t1-,2+,3+,4-,5-,6-/m1/s1</moldb-inchi>
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            <moldb-iupac>{[(1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4,6-bis(phosphonooxy)cyclohexyl]oxy}phosphonic acid</moldb-iupac>
            <moldb-average-mass>420.0956</moldb-average-mass>
            <moldb-mono-mass>419.962379346</moldb-mono-mass>
            <moldb-alogps-logs>-1.45</moldb-alogps-logs>
            <moldb-donor-count>9</moldb-donor-count>
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            <foodb-id>FDB022657</foodb-id>
            <synonyms>1d-myo-inositol 1,4,5-trisphosphate;D-myo-inositol 1,4,5-trisphosphate;Inositol 1,4,5-trisphosphate;1,4,5-insp3;D-myo-inositol-1,4,5-triphosphate;Ins(1,4,5)p3;Insp3;Ip3;1d-myo-inositol 1,4,5-trisphosphoric acid;D-myo-inositol 1,4,5-trisphosphoric acid;D-myo-inositol-1,4,5-triphosphoric acid;Inositol 1,4,5-trisphosphoric acid</synonyms>
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            <short-name>Inotp</short-name>
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            <name>Calcium</name>
            <hmdb-id>HMDB0000464</hmdb-id>
            <description>Calcium is essential for the normal growth and maintenance of bones and teeth, and calcium requirements must be met throughout life. Requirements are greatest during periods of growth, such as childhood, during pregnancy and when breast-feeding. Long-term calcium deficiency can lead to osteoporosis, in which the bone deteriorates and there is an increased risk of fractures. Adults need between 1,000 and 1,300 mg of calcium in their daily diet. Calcium is essential for living organisms, particularly in cell physiology, and is the most common metal in many animals. Physiologically, it exists as an ion in the body. Calcium combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Calcium is an important component of a healthy diet. A deficit can affect bone and tooth formation, while overretention can cause kidney stones. Vitamin D is needed to absorb calcium. Dairy products, such as milk and cheese, are a well-known source of calcium. However, some individuals are allergic to dairy products and even more people, particularly those of non-European descent, are lactose-intolerant, leaving them unable to consume dairy products. Fortunately, many other good sources of calcium exist. These include: seaweeds such as kelp, wakame and hijiki; nuts and seeds (like almonds and sesame); beans; amaranth; collard greens; okra; rutabaga; broccoli; kale; and fortified products such as orange juice and soy milk. Calcium has also been found to assist in the production of lymphatic fluids.</description>
            <cas>14127-61-8</cas>
            <kegg-id>C00076</kegg-id>
            <pubchem-cid>271</pubchem-cid>
            <chebi-id>29108</chebi-id>
            <biocyc-id>CA%2b2</biocyc-id>
            <chemspider-id>266</chemspider-id>
            <drugbank-id>DB01373</drugbank-id>
            <moldb-smiles>[Ca++]</moldb-smiles>
            <moldb-formula>Ca</moldb-formula>
            <moldb-inchi>InChI=1S/Ca/q+2</moldb-inchi>
            <moldb-inchikey>BHPQYMZQTOCNFJ-UHFFFAOYSA-N</moldb-inchikey>
            <moldb-iupac>calcium(2+) ion</moldb-iupac>
            <moldb-average-mass>40.078</moldb-average-mass>
            <moldb-mono-mass>39.962591155</moldb-mono-mass>
            <moldb-alogps-logs nil="true"/>
            <moldb-donor-count>0</moldb-donor-count>
            <moldb-traditional-iupac>calcium(2+) ion</moldb-traditional-iupac>
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            <moldb-physiological-charge type="integer">2</moldb-physiological-charge>
            <drugbank-metabolite-id nil="true"/>
            <foodb-id>FDB003513</foodb-id>
            <synonyms>Ca;Calcium element;Ca(2+);Ca2+;Calcium ion;Calcium, doubly charged positive ion</synonyms>
            <pwc-id>PW_C000353</pwc-id>
            <short-name>Ca2+</short-name>
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            <foodb-id nil="true"/>
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            <short-name>Alimem</short-name>
            <element-states>
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</description>
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            <description>Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems</description>
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            <name>Protein kinase C beta type</name>
            <uniprot-id>P05771</uniprot-id>
            <description>Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser- 652', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage:in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters</description>
            <hmdbp-id>HMDBP01372</hmdbp-id>
            <gene-name>PRKCB</gene-name>
            <locus>16p11.2</locus>
            <drugbank-id nil="true"/>
            <genbank-id>FJ907246</genbank-id>
            <species-id type="integer">1</species-id>
            <ec-numbers>2.7.11.13</ec-numbers>
            <synonyms nil="true"/>
            <element-states>
              <element-state>
                <id type="integer">69388</id>
                <biological-state-id type="integer">8</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">80052</id>
                <biological-state-id type="integer">164</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">80414</id>
                <biological-state-id type="integer">74</biological-state-id>
              </element-state>
            </element-states>
          </protein>
          <protein>
            <id type="integer">1808</id>
            <name>Nuclear factor NF-kappa-B p105 subunit</name>
            <uniprot-id>P19838</uniprot-id>
            <description>NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post- translationally. p50 binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105</description>
            <hmdbp-id>HMDBP02145</hmdbp-id>
            <gene-name>NFKB1</gene-name>
            <locus>4q24</locus>
            <drugbank-id nil="true"/>
            <genbank-id>BC051765</genbank-id>
            <species-id type="integer">1</species-id>
            <ec-numbers></ec-numbers>
            <synonyms nil="true"/>
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                <id type="integer">4145</id>
                <biological-state-id type="integer">2</biological-state-id>
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              <element-state>
                <id type="integer">4147</id>
                <biological-state-id type="integer">23</biological-state-id>
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              <element-state>
                <id type="integer">80356</id>
                <biological-state-id type="integer">8</biological-state-id>
              </element-state>
              <element-state>
                <id type="integer">115939</id>
                <biological-state-id type="integer">27</biological-state-id>
              </element-state>
            </element-states>
          </protein>
        </proteins>
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          <protein-complex>
            <id type="integer">6635</id>
            <name>Histamine H1 receptor</name>
            <species-id type="integer">1</species-id>
            <pwp-id>PW_P006635</pwp-id>
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              <protein-complex-protein>
                <id type="integer">14376</id>
                <protein-id type="integer">2116</protein-id>
                <stoichiometry type="integer" nil="true"/>
              </protein-complex-protein>
            </protein_complex-proteins>
          </protein-complex>
          <protein-complex>
            <id type="integer">6636</id>
            <name>Gαq</name>
            <species-id type="integer">1</species-id>
            <pwp-id>PW_P006636</pwp-id>
            <protein_complex-proteins>
              <protein-complex-protein>
                <id type="integer">14377</id>
                <protein-id type="integer">1740</protein-id>
                <stoichiometry type="integer" nil="true"/>
              </protein-complex-protein>
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            <element-states>
              <element-state>
                <id type="integer">69304</id>
                <biological-state-id type="integer">1</biological-state-id>
              </element-state>
            </element-states>
          </protein-complex>
          <protein-complex>
            <id type="integer">6637</id>
            <name>Gβγ</name>
            <species-id type="integer">1</species-id>
            <pwp-id>PW_P006637</pwp-id>
            <protein_complex-proteins>
              <protein-complex-protein>
                <id type="integer">14378</id>
                <protein-id type="integer">3618</protein-id>
                <stoichiometry type="integer" nil="true"/>
              </protein-complex-protein>
              <protein-complex-protein>
                <id type="integer">14379</id>
                <protein-id type="integer">1591</protein-id>
                <stoichiometry type="integer" nil="true"/>
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            <element-states>
              <element-state>
                <id type="integer">69311</id>
                <biological-state-id type="integer">1</biological-state-id>
              </element-state>
            </element-states>
          </protein-complex>
          <protein-complex>
            <id type="integer">1140</id>
            <name>Phospholipase C, beta 1</name>
            <species-id type="integer">1</species-id>
            <pwp-id>PW_P001140</pwp-id>
            <protein_complex-proteins>
              <protein-complex-protein>
                <id type="integer">1302</id>
                <protein-id type="integer">216</protein-id>
                <stoichiometry type="integer">1</stoichiometry>
              </protein-complex-protein>
            </protein_complex-proteins>
            <protein_complex-cofactors>
              <protein-complex-cofactor>
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                <stoichiometry type="integer">1</stoichiometry>
              </protein-complex-cofactor>
            </protein_complex-cofactors>
          </protein-complex>
          <protein-complex>
            <id type="integer">270</id>
            <name>Inositol 1,4,5-trisphosphate receptor type 1</name>
            <species-id type="integer">1</species-id>
            <pwp-id>PW_P000270</pwp-id>
            <protein_complex-proteins>
              <protein-complex-protein>
                <id type="integer">289</id>
                <protein-id type="integer">2126</protein-id>
                <stoichiometry type="integer">4</stoichiometry>
              </protein-complex-protein>
            </protein_complex-proteins>
          </protein-complex>
          <protein-complex>
            <id type="integer">6638</id>
            <name>protein kinase C beta</name>
            <species-id type="integer">1</species-id>
            <pwp-id>PW_P006638</pwp-id>
            <protein_complex-proteins>
              <protein-complex-protein>
                <id type="integer">14380</id>
                <protein-id type="integer">1279</protein-id>
                <stoichiometry type="integer" nil="true"/>
              </protein-complex-protein>
            </protein_complex-proteins>
            <protein_complex-cofactors>
              <protein-complex-cofactor>
                <id type="integer">744</id>
                <compound-id type="integer">353</compound-id>
                <stoichiometry type="integer">3</stoichiometry>
              </protein-complex-cofactor>
            </protein_complex-cofactors>
            <element-states>
              <element-state>
                <id type="integer">69387</id>
                <biological-state-id type="integer">8</biological-state-id>
              </element-state>
            </element-states>
          </protein-complex>
          <protein-complex>
            <id type="integer">988</id>
            <name>Nuclear factor NF-kappa-B p105 subunit</name>
            <species-id type="integer">1</species-id>
            <pwp-id>PW_P000988</pwp-id>
            <protein_complex-proteins>
              <protein-complex-protein>
                <id type="integer">1117</id>
                <protein-id type="integer">1808</protein-id>
                <stoichiometry type="integer">1</stoichiometry>
              </protein-complex-protein>
            </protein_complex-proteins>
          </protein-complex>
        </protein-complexes>
        <reactions>
          <reaction>
            <id type="integer">100922</id>
            <spontaneous type="boolean" nil="true"/>
            <pwr-id>PW_R100922</pwr-id>
            <direction>Right</direction>
            <reaction-left-elements>
              <reaction-left-element>
                <id type="integer">363368</id>
                <element-id type="integer">344</element-id>
                <stoichiometry type="integer">1</stoichiometry>
                <element-type>ElementCollection</element-type>
                <currency type="boolean">false</currency>
              </reaction-left-element>
              <reaction-left-element>
                <id type="integer">363369</id>
                <element-id type="integer">1420</element-id>
                <stoichiometry type="integer">1</stoichiometry>
                <element-type>Compound</element-type>
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            <reaction-right-elements>
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                <element-type>ElementCollection</element-type>
                <currency type="boolean">false</currency>
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                <id type="integer">363371</id>
                <element-id type="integer">1155</element-id>
                <stoichiometry type="integer">1</stoichiometry>
                <element-type>Compound</element-type>
                <currency type="boolean">false</currency>
              </reaction-right-element>
            </reaction-right-elements>
            <reaction-enzymes>
              <reaction-enzyme>
                <id type="integer">91035</id>
                <protein-complex-id type="integer">1140</protein-complex-id>
                <enzyme-class nil="true"/>
              </reaction-enzyme>
            </reaction-enzymes>
          </reaction>
          <reaction>
            <id type="integer">101579</id>
            <spontaneous type="boolean" nil="true"/>
            <pwr-id>PW_R101579</pwr-id>
            <direction>Right</direction>
            <reaction-left-elements>
              <reaction-left-element>
                <id type="integer">365996</id>
                <element-id type="integer">24</element-id>
                <stoichiometry type="integer">1</stoichiometry>
                <element-type>Bound</element-type>
                <currency type="boolean">false</currency>
              </reaction-left-element>
            </reaction-left-elements>
            <reaction-right-elements>
              <reaction-right-element>
                <id type="integer">365997</id>
                <element-id type="integer">26</element-id>
                <stoichiometry type="integer">1</stoichiometry>
                <element-type>Bound</element-type>
                <currency type="boolean">false</currency>
              </reaction-right-element>
              <reaction-right-element>
                <id type="integer">365998</id>
                <element-id type="integer">27</element-id>
                <stoichiometry type="integer">1</stoichiometry>
                <element-type>Bound</element-type>
                <currency type="boolean">false</currency>
              </reaction-right-element>
              <reaction-right-element>
                <id type="integer">365999</id>
                <element-id type="integer">6637</element-id>
                <stoichiometry type="integer">1</stoichiometry>
                <element-type>ProteinComplex</element-type>
                <currency type="boolean">false</currency>
              </reaction-right-element>
            </reaction-right-elements>
          </reaction>
        </reactions>
        <reaction-coupled-transports>
        </reaction-coupled-transports>
        <transports>
          <transport>
            <id type="integer">1035</id>
            <pwt-id>PW_T001035</pwt-id>
            <transport-type nil="true"/>
            <transport-elements>
              <transport-element>
                <id type="integer">1259</id>
                <element-id type="integer">353</element-id>
                <stoichiometry type="integer">1</stoichiometry>
                <element-type>Compound</element-type>
                <left-biological-state-id type="integer">18</left-biological-state-id>
                <right-biological-state-id type="integer">8</right-biological-state-id>
                <direction>Right</direction>
              </transport-element>
            </transport-elements>
            <transport-transporters>
              <transport-transporter>
                <id type="integer">922</id>
                <protein-complex-id type="integer">270</protein-complex-id>
                <altext nil="true"/>
                <created-at type="dateTime">2017-09-13T12:02:00-06:00</created-at>
                <updated-at type="dateTime">2017-09-13T12:02:00-06:00</updated-at>
                <biological-state-id type="integer">49</biological-state-id>
              </transport-transporter>
            </transport-transporters>
          </transport>
        </transports>
        <interactions>
          <interaction>
            <id type="integer">240</id>
            <interaction-type>Activation</interaction-type>
            <pwi-id>PW_I000240</pwi-id>
            <interaction-left-elements>
              <interaction-left-element>
                <id type="integer">479</id>
                <element-id type="integer">693</element-id>
                <element-type>Compound</element-type>
                <stoichiometry type="integer">1</stoichiometry>
              </interaction-left-element>
            </interaction-left-elements>
            <interaction-right-elements>
              <interaction-right-element>
                <id type="integer">480</id>
                <element-id type="integer">24</element-id>
                <element-type>Bound</element-type>
                <stoichiometry type="integer">1</stoichiometry>
              </interaction-right-element>
            </interaction-right-elements>
          </interaction>
          <interaction>
            <id type="integer">241</id>
            <interaction-type>Activation</interaction-type>
            <pwi-id>PW_I000241</pwi-id>
            <interaction-left-elements>
              <interaction-left-element>
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                <element-type>Bound</element-type>
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              </interaction-left-element>
            </interaction-left-elements>
            <interaction-right-elements>
              <interaction-right-element>
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                <element-id type="integer">1140</element-id>
                <element-type>ProteinComplex</element-type>
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          <interaction>
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            <interaction-type>Activation</interaction-type>
            <pwi-id>PW_I000242</pwi-id>
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              <interaction-left-element>
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                <element-type>Compound</element-type>
                <stoichiometry type="integer">1</stoichiometry>
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          <interaction>
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            <interaction-type>Activation</interaction-type>
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              <interaction-left-element>
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                <element-id type="integer">295</element-id>
                <element-type>ElementCollection</element-type>
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              <interaction-right-element>
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                <element-type>ProteinComplex</element-type>
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          <interaction>
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            <interaction-type>Activation</interaction-type>
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              <interaction-left-element>
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                <element-id type="integer">353</element-id>
                <element-type>Compound</element-type>
                <stoichiometry type="integer">1</stoichiometry>
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            <interaction-right-elements>
              <interaction-right-element>
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                <element-id type="integer">6638</element-id>
                <element-type>ProteinComplex</element-type>
                <stoichiometry type="integer">1</stoichiometry>
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          <interaction>
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            <interaction-type>Activation</interaction-type>
            <pwi-id>PW_I000245</pwi-id>
            <interaction-left-elements>
              <interaction-left-element>
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                <element-id type="integer">6638</element-id>
                <element-type>ProteinComplex</element-type>
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            <interaction-right-elements>
              <interaction-right-element>
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                <element-type>ProteinComplex</element-type>
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            </interaction-right-elements>
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          <interaction>
            <id type="integer">280</id>
            <interaction-type>Inhibition</interaction-type>
            <pwi-id>PW_I000280</pwi-id>
            <interaction-left-elements>
              <interaction-left-element>
                <id type="integer">559</id>
                <element-id type="integer">9653</element-id>
                <element-type>Compound</element-type>
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            <interaction-right-elements>
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                <element-type>Bound</element-type>
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              <bound-protein-complex-visualization>
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              <bound-protein-complex-visualization>
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              <interaction-compound-visualization>
                <id type="integer">329</id>
                <compound-location-id type="integer">1484904</compound-location-id>
                <edge-id type="integer">2026888</edge-id>
                <side>Left</side>
              </interaction-compound-visualization>
            </interaction_compound_visualizations>
            <interaction_protein_complex_visualizations>
              <interaction-protein-complex-visualization>
                <id type="integer">1025</id>
                <protein-complex-visualization-id type="integer">451792</protein-complex-visualization-id>
                <edge-id type="integer">2026889</edge-id>
                <side>Right</side>
              </interaction-protein-complex-visualization>
            </interaction_protein_complex_visualizations>
          </interaction-visualization>
          <interaction-visualization>
            <id type="integer">863</id>
            <interaction-id type="integer">245</interaction-id>
            <pathway-visualization-id type="integer">60379</pathway-visualization-id>
            <biological-state-id type="integer">23</biological-state-id>
            <interaction_protein_complex_visualizations>
              <interaction-protein-complex-visualization>
                <id type="integer">1026</id>
                <protein-complex-visualization-id type="integer">451792</protein-complex-visualization-id>
                <edge-id type="integer">2026890</edge-id>
                <side>Left</side>
              </interaction-protein-complex-visualization>
              <interaction-protein-complex-visualization>
                <id type="integer">1027</id>
                <protein-complex-visualization-id type="integer">451793</protein-complex-visualization-id>
                <edge-id type="integer">2026891</edge-id>
                <side>Right</side>
              </interaction-protein-complex-visualization>
            </interaction_protein_complex_visualizations>
          </interaction-visualization>
          <interaction-visualization>
            <id type="integer">938</id>
            <interaction-id type="integer">280</interaction-id>
            <pathway-visualization-id type="integer">60379</pathway-visualization-id>
            <biological-state-id type="integer">308</biological-state-id>
            <interaction_bound_visualizations>
              <interaction-bound-visualization>
                <id type="integer">238</id>
                <bound-visualization-id type="integer">183</bound-visualization-id>
                <edge-id type="integer">2029133</edge-id>
                <side>Right</side>
              </interaction-bound-visualization>
            </interaction_bound_visualizations>
            <interaction_compound_visualizations>
              <interaction-compound-visualization>
                <id type="integer">374</id>
                <compound-location-id type="integer">1486481</compound-location-id>
                <edge-id type="integer">2029132</edge-id>
                <side>Left</side>
              </interaction-compound-visualization>
            </interaction_compound_visualizations>
          </interaction-visualization>
        </interaction-visualizations>
        <sub-pathway-visualizations>
          <sub-pathway-visualization>
            <id type="integer">52622</id>
            <sub-pathway-id type="integer">53241</sub-pathway-id>
            <pathway-visualization-id type="integer">60379</pathway-visualization-id>
            <visualization-template-id type="integer">217</visualization-template-id>
            <hidden type="boolean">false</hidden>
            <x type="integer">207</x>
            <y type="integer">124</y>
            <zindex type="integer">16</zindex>
            <font-size>regular</font-size>
            <sub_pathway_compound_visualizations>
              <sub-pathway-compound-visualization>
                <id type="integer">49577</id>
                <compound-location-id type="integer">1484908</compound-location-id>
                <edge-id type="integer">2026894</edge-id>
                <side>Right</side>
              </sub-pathway-compound-visualization>
            </sub_pathway_compound_visualizations>
          </sub-pathway-visualization>
        </sub-pathway-visualizations>
        <vacuous-compound-visualizations>
        </vacuous-compound-visualizations>
        <vacuous-edge-visualizations>
        </vacuous-edge-visualizations>
        <vacuous-nucleic-acid-visualizations>
        </vacuous-nucleic-acid-visualizations>
        <vacuous-element-collection-visualizations>
        </vacuous-element-collection-visualizations>
        <vacuous-protein-visualizations>
        </vacuous-protein-visualizations>
        <drawable-element-locations>
          <drawable-element-location>
            <id type="integer">99316</id>
            <visualization-template-id type="integer" nil="true"/>
            <x type="integer">1939</x>
            <y type="integer">769</y>
            <scale-x type="decimal">0.6</scale-x>
            <scale-y type="decimal">0.6</scale-y>
            <degree type="integer">-90</degree>
            <zindex type="integer">2</zindex>
            <drawable-image-id type="integer">3</drawable-image-id>
            <width>280</width>
            <height>360</height>
          </drawable-element-location>
          <drawable-element-location>
            <id type="integer">99317</id>
            <visualization-template-id type="integer" nil="true"/>
            <x type="integer">220</x>
            <y type="integer">805</y>
            <scale-x type="decimal">1.0</scale-x>
            <scale-y type="decimal">1.0</scale-y>
            <degree type="integer">0</degree>
            <zindex type="integer">2</zindex>
            <drawable-image-id type="integer">14</drawable-image-id>
            <width>327</width>
            <height>267</height>
          </drawable-element-location>
        </drawable-element-locations>
        <membrane-visualizations>
          <membrane-visualization>
            <id type="integer">208505</id>
            <path>M125 626.5 C125 576.5 175 526.5 225 526.5 C801 526.5 1549 526.5 2125 526.5 C2175 526.5 2225 576.5 2225 626.5 C2225 758.5 2225 931.5 2225 1063.5 C2225 1113.5 2175 1163.5 2125 1163.5 C1549 1163.5 801 1163.5 225 1163.5 C175 1163.5 125 1113.5 125 1063.5 C125 931.5 125 758.5 125 626.5 </path>
            <visualization-template-id type="integer">1</visualization-template-id>
            <complete-membrane type="boolean">true</complete-membrane>
            <zindex type="integer">6</zindex>
            <width>0.0</width>
            <height>0.0</height>
          </membrane-visualization>
          <membrane-visualization>
            <id type="integer">208506</id>
            <path>M1855 1076.5 C1855 1036.5 1855 839.5 1855 789.5 </path>
            <visualization-template-id type="integer">91</visualization-template-id>
            <complete-membrane type="boolean">false</complete-membrane>
            <zindex type="integer">6</zindex>
            <width>0.0</width>
            <height>0.0</height>
          </membrane-visualization>
        </membrane-visualizations>
        <label-locations>
          <label-location>
            <id type="integer">224943</id>
            <visualization-template-id type="integer">15</visualization-template-id>
            <label-text>Endoplasmic Reticulum</label-text>
            <x type="integer">1894</x>
            <y type="integer">772</y>
            <zindex type="integer">20</zindex>
            <scale-x type="decimal">1.0</scale-x>
            <scale-y type="decimal">1.0</scale-y>
            <width>160</width>
            <height>15</height>
          </label-location>
          <label-location>
            <id type="integer">224944</id>
            <visualization-template-id type="integer">15</visualization-template-id>
            <label-text>Nucleus</label-text>
            <x type="integer">295</x>
            <y type="integer">802</y>
            <zindex type="integer">20</zindex>
            <scale-x type="decimal">1.0</scale-x>
            <scale-y type="decimal">1.0</scale-y>
            <width>160</width>
            <height>15</height>
          </label-location>
          <label-location>
            <id type="integer">224945</id>
            <visualization-template-id type="integer">15</visualization-template-id>
            <label-text>Calcium Ion Channel</label-text>
            <x type="integer">1771</x>
            <y type="integer">999</y>
            <zindex type="integer">20</zindex>
            <scale-x type="decimal">1.0</scale-x>
            <scale-y type="decimal">1.0</scale-y>
            <width>160</width>
            <height>15</height>
          </label-location>
          <label-location>
            <id type="integer">224946</id>
            <visualization-template-id type="integer">15</visualization-template-id>
            <label-text>Cell Membrane</label-text>
            <x type="integer">1170</x>
            <y type="integer">1124</y>
            <zindex type="integer">20</zindex>
            <scale-x type="decimal">1.0</scale-x>
            <scale-y type="decimal">1.0</scale-y>
            <width>160</width>
            <height>15</height>
          </label-location>
          <label-location>
            <id type="integer">224947</id>
            <visualization-template-id type="integer">15</visualization-template-id>
            <label-text>Cytoplasm</label-text>
            <x type="integer">1170</x>
            <y type="integer">1069</y>
            <zindex type="integer">20</zindex>
            <scale-x type="decimal">1.0</scale-x>
            <scale-y type="decimal">1.0</scale-y>
            <width>160</width>
            <height>15</height>
          </label-location>
          <label-location>
            <id type="integer">224948</id>
            <visualization-template-id type="integer">235</visualization-template-id>
            <label-text>↑ Antigen Presentation</label-text>
            <x type="integer">485</x>
            <y type="integer">814</y>
            <zindex type="integer">20</zindex>
            <scale-x type="decimal">1.3</scale-x>
            <scale-y type="decimal">1.3</scale-y>
            <width>200</width>
            <height>15</height>
          </label-location>
          <label-location>
            <id type="integer">224949</id>
            <visualization-template-id type="integer">235</visualization-template-id>
            <label-text>↑ Pro-inflammatory Cytokines, Cell Adhesion Molecules, Chemotactic Factors</label-text>
            <x type="integer">486</x>
            <y type="integer">956</y>
            <zindex type="integer">14</zindex>
            <scale-x type="decimal">1.3</scale-x>
            <scale-y type="decimal">1.3</scale-y>
            <width>200</width>
            <height>15</height>
          </label-location>
          <label-location>
            <id type="integer">224950</id>
            <visualization-template-id type="integer">235</visualization-template-id>
            <label-text>↑ Mediator Release</label-text>
            <x type="integer">1488</x>
            <y type="integer">971</y>
            <zindex type="integer">20</zindex>
            <scale-x type="decimal">1.3</scale-x>
            <scale-y type="decimal">1.3</scale-y>
            <width>200</width>
            <height>15</height>
          </label-location>
          <label-location>
            <id type="integer">224951</id>
            <visualization-template-id type="integer">235</visualization-template-id>
            <label-text>↓ Mast Cell Stabilization</label-text>
            <x type="integer">1486</x>
            <y type="integer">1036</y>
            <zindex type="integer">20</zindex>
            <scale-x type="decimal">1.3</scale-x>
            <scale-y type="decimal">1.3</scale-y>
            <width>200</width>
            <height>15</height>
          </label-location>
        </label-locations>
        <zoom-visualizations>
          <zoom-visualization>
            <id type="integer">98247</id>
            <p1x type="integer">2001</p1x>
            <p1y type="integer">680</p1y>
            <p2x type="integer">1829</p2x>
            <p2y type="integer">788</p2y>
            <p3x type="integer">2128</p3x>
            <p3y type="integer">1077</p3y>
            <visualization-template-id type="integer">4</visualization-template-id>
            <color>#FFEEDE</color>
            <zindex type="integer">4</zindex>
            <label></label>
            <width>299</width>
            <height>289</height>
          </zoom-visualization>
        </zoom-visualizations>
      </pathway-visualization>
    </pathway-visualization-context>
  </pathway-visualization-contexts>
</super-pathway-visualization>
