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Serine palmitoyltransferase 2 Serine palmitoyltransferase 1 3- ketodihydrosphingosine reductase Sphingosine kinase 2 Sphingosine- 1-phosphate phosphatase 2 Phospholipid phosphatase 1 Sphingosine- 1-phosphate lyase 1 Sphingolipid delta(4)- desaturase/C4- monooxygenase DES2 Sphingosine- 1-phosphate lyase 1 Sphingosine kinase 2 Sphingosine- 1-phosphate phosphatase 2 Phospholipid phosphatase 1 Alkaline ceramidase 1 Ceramide kinase Phospholipid phosphatase 1 Sphingosine- 1-phosphate phosphatase 2 Phosphatidylcholine:ceramide cholinephosphotransferase 1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 2- hydroxyacylsphingosine 1-beta- galactosyltransferase Galactocerebrosidase Glucosylceramidase Ceramide glucosyltransferase Unknown Beta-1,4- galactosyltransferase 6 Galactosylceramide sulfotransferase Arylsulfatase A Alpha- galactosidase A Galactosylceramide sulfotransferase Sialidase-3 Alkaline ceramidase 3 L-Serine Palmityl-CoA 3-Dehydrosphinganine Sphinganine NADPH NADP ATP ADP Sphinganine 1-phosphate ADP ATP Pi O- Phosphoethanolamine Dihydroceramide Ceramide (d18:1/18:0) Sphingosine 1-phosphate Sphingosine ATP ADP ADP ATP Pi ATP CerP(d18:1/12:0) ADP Pi SM(d18:1/18:0) Accumulation Galactosylceramide (d18:1/16:0) Glucosylceramide Lactosylceramide (d18:1/12:0) Phosphoadenosine phosphosulfate 3-O-Sulfogalactosylceramide (d18:1/24:0) Adenosine 3',5'- diphosphate H2O Sulfate D-Galactose Galabiosylceramide (d18:1/22:0) Phosphoadenosine phosphosulfate Adenosine 3',5'- diphosphate N-acetylneuraminyl- Galactosylceramide Sphinganine Pyridoxal 5'-phosphate Magnesium Pyridoxal 5'-phosphate Pyridoxal 5'-phosphate Magnesium Calcium Magnesium Magnesium Zinc Calcium Galabiosylceramide- sulfate Glycine and Serine Metabolism Intracellular space Endoplasmic Reticulum Golgi complex Golgi complex Lysosome Lysosome Endoplasmic Reticulum
Sptlc2 Sptlc1 Kdsr Sphk2 Sgpp2 Plpp1 Sgpl1 Degs2 Sgpl1 Sphk2 Sgpp2 Plpp1 Acer1 Cerk Plpp1 Sgpp2 Sgms1 Enpp5 Ugt8 Galc Gba Ugcg Unknown B4galt6 Gal3st1 Arsa Gla Gal3st1 Neu3 Acer3 L-Serine Palmityl-CoA 3- Dehydrosphinganine Sphinganine NADPH NADP Adenosine triphosphate Adenosine diphosphate Sphinganine 1-phosphate Adenosine diphosphate Adenosine triphosphate Phosphate O- Phosphoethanolamine Dihydroceramide Ceramide (d18:1/18:0) Sphingosine 1-phosphate Sphingosine Adenosine triphosphate Adenosine diphosphate Adenosine diphosphate Adenosine triphosphate Phosphate Adenosine triphosphate CerP(d18:1/12:0) Adenosine diphosphate Phosphate SM(d18:1/18:0) Accumulation Galactosylceramide (d18:1/16:0) Glucosylceramide Lactosylceramide (d18:1/12:0) Phosphoadenosine phosphosulfate 3-O- Sulfogalactosylceramide (d18:1/24:0) Adenosine 3',5'- diphosphate Water Sulfate D-Galactose Galabiosylceramide (d18:1/22:0) Phosphoadenosine phosphosulfate Adenosine 3',5'- diphosphate N- acetylneuraminyl- Galactosylceramide Sphinganine Galabiosylceramide- sulfate Glycine and Serine Metabolism
Sptlc2 Sptlc1 Kdsr Sphk2 Sgpp2 Plpp1 Sgpl1 Degs2 Sgpl1 Sphk2 Sgpp2 Plpp1 Acer1 Cerk Plpp1 Sgpp2 Sgms1 Enpp5 Ugt8 Galc Gba Ugcg B4galt6 Gal3st1 Arsa Gla Gal3st1 Neu3 Acer3 Ser COA16:0 3-DHPG d18:0 NADPH NADP ATP ADP Sphg-1P ADP ATP Pi Ethamp DHCeram Ceram18 S1P Sphingo ATP ADP ADP ATP Pi ATP N-LAURO ADP Pi Sphingo Accumulation Galcer Glccera Cdh Paps Sulfati A3'5'PP H2O SO4 D-Gal Digalac Paps A3'5'PP NAG d18:0 Pyr-5'P Mg2+ Pyr-5'P Pyr-5'P Mg2+ Ca2+ Mg2+ Mg2+ Zinc Ca2+ GS PW000157 Intracellular space Endoplasmic Reticulum Golgi complex Golgi complex Lysosome Lysosome Endoplasmic Reticulum
Sptlc2 Sptlc1 Kdsr Sphk2 Sgpp2 Plpp1 Sgpl1 Degs2 Sgpl1 Sphk2 Sgpp2 Plpp1 Acer1 Cerk Plpp1 Sgpp2 Sgms1 Enpp5 Ugt8 Galc Gba Ugcg B4galt6 Gal3st1 Arsa Gla Gal3st1 Neu3 Acer3 Ser COA16:0 3-DHPG d18:0 NADPH NADP ATP ADP Sphg-1P ADP ATP Pi Ethamp DHCeram Ceram18 S1P Sphingo ATP ADP ADP ATP Pi ATP N-LAURO ADP Pi Sphingo Accumulation Galcer Glccera Cdh Paps Sulfati A3'5'PP H2O SO4 D-Gal Digalac Paps A3'5'PP NAG d18:0 GS PW000157