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Guanylate cyclase soluble subunit beta-2 Guanylate cyclase soluble subunit alpha-2 Guanylate cyclase soluble subunit alpha-3 Guanylate cyclase soluble subunit beta-1 cGMP-dependent protein kinase 1 cGMP-dependent protein kinase 2 cGMP-specific 3',5'-cyclic phosphodiesterase Sildenafil transporter Myosin light chain 3 Myosin light chain 3 Myosin light chain phosphatase NO Cyclic GMP Sildenafil NO NO NO NO Sildenafil GTP PPi H2O Guanosine monophosphate H+ Manganese Series of phosphorylations Sexual stimulation Endothelial cell Neuron Smooth muscle cell Cytosol Sexual stimulation causes the release of nitric oxide from nerves and endothelial cells into the penis Nitric oxide diffuses into the smooth muscle cells of the penis and activates guanylyl cyclase, leading to a high concentration of cGMP cGMP activates a protein kinase, which together with cGMP, causes a series of phosphorylation that leads to decrease in intracellular calcium, increased efflux of potassium, and dephosphorylation of myosin light chain kinase which ultimately results in smooth muscle relaxation and increased blood flow to the penis leading to erection. Sildenafil prevents the breakdown of cGMP, thus maintaining a high concentration of cGMP in the cytosol to maintain muscle relaxation Blood vessel dilates, increasing blood flow
GUCY1B2 GUCY1A2 GUCY1A3 GUCY1B3 PRKG1 PRKG2 PDE5A Unknown MYL3 MYL3 PPP1CB Nitric oxide Cyclic GMP Sildenafil Nitric oxide Nitric oxide Nitric oxide Nitric oxide Sildenafil Guanosine triphosphate Pyrophosphate Water Guanosine monophosphate Hydrogen Ion Series of phosphorylations
GUCY1B2 GUCY1A2 GUCY1A3 GUCY1B3 PRKG1 PRKG2 PDE5A MYL3 MYL3 PPP1CB NO cGMP Viagra NO NO NO NO Viagra GTP PPi H2O GSMP H+ Mn2+ Se of p Sexual stimulation Endothelial cell Neuron Smooth muscle cell Cytosol Sexual stimulation causes the release of nitric oxide from nerves and endothelial cells into the penis Nitric oxide diffuses into the smooth muscle cells of the penis and activates guanylyl cyclase, leading to a high concentration of cGMP cGMP activates a protein kinase, which together with cGMP, causes a series of phosphorylation that leads to decrease in intracellular calcium, increased efflux of potassium, and dephosphorylation of myosin light chain kinase which ultimately results in smooth muscle relaxation and increased blood flow to the penis leading to erection. Sildenafil prevents the breakdown of cGMP, thus maintaining a high concentration of cGMP in the cytosol to maintain muscle relaxation Blood vessel dilates, increasing blood flow