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Solute carrier family 22 member 1 Haloperidol intestinal transporter Haloperidol pyridinium ion derivative transporter Haloperidol glucuronide transporter 4-(4- Chlorophenyl)- 1-[4-(4- fluorophenyl)- 4-oxobutyl]- pyridinium (HPP+) transporter Fluorobenzoylpropionic acid transporter 4-(4- chlorophenyl)- 4- hydroxypiperidine transporter Carbonyl reductase [NADPH] 1 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 UDP- glucuronosyltransferase 1-9 Unknown Haloperidol glucuronide Haloperidol pyridinium ion derivative 4-(4- chlorophenyl)- 4- hydroxypiperidine Fluorobenzoylpropionic acid 4-(4- Chlorophenyl)- 1-[4-(4- fluorophenyl)- 4-oxobutyl]- pyridinium (HPP+) Haloperidol Haloperidol Haloperidol Haloperidol Haloperidol Haloperidol pyridinium ion derivative Haloperidol glucuronide 4-(4- Chlorophenyl)- 1-[4-(4- fluorophenyl)- 4-oxobutyl]- pyridinium (HPP+) Fluorobenzoylpropionic acid 4-(4- chlorophenyl)- 4- hydroxypiperidine NADPH H+ Reduced Haloperidol NADP H+ H2O Flavin Mononucleotide Haloperidol reduced pyridinium ion derivative O2 FMNH2 H+ H2O Flavin Mononucleotide FMNH2 O2 H+ H2O Flavin Mononucleotide Haloperidol 1,2,3,6- tetrahydropyridine O2 FMNH2 H+ Flavin Mononucleotide H2O FMNH2 O2 Uridine diphosphate glucuronic acid H+ Uridine 5'-diphosphate Heme Heme Heme Heme Heme Excretion Haloperidol is taken orally Endoplasmic Reticulum Cytosol Hepatocyte Intestinal Epithelial Cell
Endoplasmic Reticulum SLC22A1 Unknown Unknown Unknown Unknown Unknown Unknown CBR1 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 UGT1A9 Unknown Haloperidol glucuronide Haloperidol pyridinium ion derivative 4-(4- chlorophenyl)- 4- hydroxypiperidine Fluorobenzoylpropionic acid 4-(4- Chlorophenyl)- 1-[4-(4- fluorophenyl)- 4-oxobutyl]- pyridinium (HPP+) Haloperidol Haloperidol Haloperidol Haloperidol Haloperidol Haloperidol pyridinium ion derivative Haloperidol glucuronide 4-(4- Chlorophenyl)- 1-[4-(4- fluorophenyl)- 4-oxobutyl]- pyridinium (HPP+) Fluorobenzoylpropionic acid 4-(4- chlorophenyl)- 4- hydroxypiperidine NADPH Hydrogen Ion Reduced Haloperidol NADP Hydrogen Ion Water Flavin Mononucleotide Haloperidol reduced pyridinium ion derivative Oxygen FMNH2 Hydrogen Ion Water Flavin Mononucleotide FMNH2 Oxygen Hydrogen Ion Water Flavin Mononucleotide Haloperidol 1,2,3,6- tetrahydropyridine Oxygen FMNH2 Hydrogen Ion Flavin Mononucleotide Water FMNH2 Oxygen Uridine diphosphate glucuronic acid Hydrogen Ion Uridine 5'-diphosphate Excretion