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Venlafaxine intestinal transporter Solute carrier family 22 member 1 ATP-binding cassette sub-family C member 3 N,O- Didesmethylvenlafaxine transporter N- Desmethylvenlafaxine transporter N,O- Didesmethylvenlafaxine glucuronide transporter O- Desmethylvenlafaxine glucuronide transporter N,N,O- Tridesmethylvenlafaxine transporter Desvenlafaxine transporter Cytochrome P450 3A4 Cytochrome P450 2C19 Cytochrome P450 2D6 UDP- glucuronosyltransferase 1-9 Cytochrome P450 3A4 UDP- glucuronosyltransferase 1-9 Cytochrome P450 3A4 Venlafaxine Desvenlafaxine O- Desmethylvenlafaxine glucuronide N,O- Didesmethylvenlafaxine N,N,O- Tridesmethylvenlafaxine N,O- Didesmethylvenlafaxine glucuronide N- Desmethylvenlafaxine Venlafaxine Venlafaxine Venlafaxine Venlafaxine Venlafaxine Venlafaxine N,O- Didesmethylvenlafaxine N- Desmethylvenlafaxine N,O- Didesmethylvenlafaxine glucuronide O- Desmethylvenlafaxine glucuronide N,N,O- Tridesmethylvenlafaxine Desvenlafaxine O2 NADH Formaldehyde NAD H2O O2 NADH Formaldehyde NAD H2O O2 NADH NAD H2O Formaldehyde Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ NADH O2 N,O- Didesmethylvenlafaxine NAD H2O Formaldehyde Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ NADH O2 NADH H2O Formaldehyde Heme Heme Heme Heme Excretion Heme Cytosol Hepatocyte Endoplasmic Reticulum Intestinal Epithelial Cell
Endoplasmic Reticulum Unknown SLC22A1 ABCC3 Unknown Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP2C19 CYP2D6 UGT1A9 CYP3A4 UGT1A9 CYP3A4 Venlafaxine Desvenlafaxine O- Desmethylvenlafaxine glucuronide N,O- Didesmethylvenlafaxine N,N,O- Tridesmethylvenlafaxine N,O- Didesmethylvenlafaxine glucuronide N- Desmethylvenlafaxine Venlafaxine Venlafaxine Venlafaxine Venlafaxine Venlafaxine Venlafaxine N,O- Didesmethylvenlafaxine N- Desmethylvenlafaxine N,O- Didesmethylvenlafaxine glucuronide O- Desmethylvenlafaxine glucuronide N,N,O- Tridesmethylvenlafaxine Desvenlafaxine Oxygen NADH Formaldehyde NAD Water Oxygen NADH Formaldehyde NAD Water Oxygen NADH NAD Water Formaldehyde Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion NADH Oxygen N,O- Didesmethylvenlafaxine NAD Water Formaldehyde Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion NADH Oxygen NADH Water Formaldehyde Excretion