RPTOR
NFKB1
TLR4
IRF3
STAT1
NOS2
TNF
IL6
IL1B
ACOD1
CRH
ACOD1
Succinate
dehydrogenase
[ubiquinone]
flavoprotein
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
iron-sulfur
subunit,
mitochondrial
Succinate
dehydrogenase
cytochrome b560
subunit,
mitochondrial
Succinate
dehydrogenase
EGLN2
HIF1A
SLC2A1
IL1B
IFNG
IDO1
IDO1
IL10
IRF3
IFNAR1
IFNAR2
IFNB1
HK2
IL1B
IL1B
IL10
MTOR
IL1B
IL6
IFNAR1
IFNAR2
IFNB1
TNF
NOS2
Solute carrier
family 2,
facilitated
glucose
transporter
member 2
Solute carrier
family 22
member 5
Solute carrier
family 13
member 3
Solute carrier
family 2,
facilitated
glucose
transporter
member 1
Monocarboxylate
transporter 4
Histone H4
Importin-4
IL1B
Interleukin
enhancer-
binding factor
3
Exportin-5
Low affinity
cationic amino
acid
transporter 2
Solute carrier
family 22
member 8
Solute carrier
family 22
member 2
Solute carrier
family 22
member 2
Solute carrier
family 22
member 8
Interleukin
Transport
IL6
IL1B
TNF
IFNAR1
IFNAR2
IFNB1
IL1B
IL1B
IL6
IL6
TNF
TNF
Histone H4
Importin-4
NOS2
AFMID
AHR
NFKB1
PKM
PKM
AHR
NFKB1
AHR
PKM
AHR
Tetrahydrobiopterin
MYD88
TICAM2
Flavin
Mononucleotide
Flavin
Mononucleotide
Tetrahydrobiopterin
TICAM1
PKM
Adrenocorticotropic
hormone
Adrenocorticotropic
hormone
Cortisol
Epinephrine
Lipopolysaccharide
D-Glucose
L-Lactic acid
L-Tryptophan
NO
Citric acid
L-Acetylcarnitine
D-Glucose
D-Glucose
L-Acetylcarnitine
L-Acetylcarnitine
NO
NO
Succinic acid
Succinic acid
L-Lactic acid
L-Arginine
L-Arginine
Cortisol
Epinephrine
Epinephrine
Cortisol
H+
NADPH
O2
L-Arginine
Citrulline
NADP
H2O
Q
FAD
Fumaric acid
QH2
FADH2
H+
NADPH
O2
Citrulline
NADP
H2O
NO
O2
N'-
Formylkynurenine
H2O
L-Kynurenine
Formic acid
L-Threonine
L-Lysine
L-Tryptophan
L-Leucine
L-Isoleucine
L-Valine
L-Arginine
Glycine
L-Serine
L-Lactic acid
Heme
FAD
2Fe-2S
Heme
Heme
FAD
Flavin
Mononucleotide
Tetrahydrobiopterin
Succinic acid
Succinic acid
L-Kynurenine
L-Kynurenine
Succinic acid
L-Kynurenine
HIF1A
HIF1A
NFKB1
Aerobic
Glycolysis
(Warburg
Effect)
Aerobic
Glycolysis
(Warburg
Effect)
Aerobic
Glycolysis
(Warburg
Effect)
Anti-
inflammatory
pathway
General Control
Non-Depressible
2 Kinase
(GCN2K) Pathway
Protein Kinase
C Signaling
T cell
Autophagy and
Anergy
Virus Not
Cleared
Tricarboxylic
acid cycle
Heme
FAD
Fe2+
Ascorbic acid
Heme
FAD
Inflammasome
Nucleus
Cell Division
Hypothalamus
Pituitary Gland
Adrenal Cortex
Liver
Blood Vessel
Macrophage
Blood Vessel
Dilation
Overstimulation
T Cell Apoptosis
T Cell Proliferation
Organ Failure
T Cell
Nucleus
Cytosol