Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
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DNA topoisomerase 2-alpha Daunorubicin nuclear transporter Solute carrier family 22 member 1 Daunorubicin Daunorubicin Daunorubicin Magnesium DNA and RNA synthesis DNA repair DNA strand break Daunorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex. This prevents the religation portion of the ligation-religation reaction topoisomerase II catalyzes, leading to DNA damage. Repair of DNA strand breaks cannot occur since DNA toposiomerase II is non-functional. This leads to errors in DNA synthesis. Cancer cell Nucleus Apoptosis Daunorubicin enters the cell via the solute carrier family 22 member 16 transporter and is transported into the nucleus. DNA damage promotes apoptosis of the cancer cell. Cytosol Daunorubicin forms a complex with DNA by intercalation between base pairs. This results in DNA strand breaks, partial unwinding of DNA at the site of intercalation and inhibition of DNA and RNA synthesis. Blood vessel
Nucleus TOP2A Unknown SLC22A1 Daunorubicin Daunorubicin Daunorubicin DNA and RNA synthesis