Oliceridine Opioid Agonist Action Pathway
type: Pathway
pathway order: PathwayInteraction/3393
pathway order: PathwayInteraction/3392
pathway order: PathwaySubPathway/121636
pathway order: PathwayTransport/2538709
pathway order: PathwayEnzymeReaction/2538645
pathway order: PathwayTransport/2538646
pathway order: PathwayTransport/2538647
pathway order: PathwayInteraction/3354
pathway order: PathwayInteraction/4046
pathway order: PathwayTransport/2538648
pathway order: PathwayInteraction/3395
pathway order: PathwayInteraction/5221
pathway order: PathwayInteraction/3394
pathway component: Interaction3392
pathway component: TransportCatalysis5713
pathway component: Interaction3393
pathway component: Interaction3394
pathway component: TransportCatalysis5930
pathway component: Interaction3395
pathway component: Interaction5221
pathway component: Interaction3354
pathway component: Interaction4046
pathway component: Transport15179
pathway component: Transport15982
pathway component: Transport15981
pathway component: Pain
pathway component: ReactionCatalysis80
pathway component: Transport16164
pathway component: 4.6.1.1
xref: Reference/SMPDB SMP0126824
xref: Reference/PathWhiz PW128429
organism: Homo sapiens

Gβ
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState789

Protein/3425 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit beta-2
stoichiometric coefficient: 1.0

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Protein/4836 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(i) subunit alpha-1
stoichiometric coefficient: 1.0

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP
name: SubPathwayInput

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

Oliceridine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Oliceridine

Reference/CAS 33507-63-0
type: UnificationXref
id: 33507-63-0
db: CAS

direct_interaction
type: InteractionVocabulary

Transport15179
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Spinal cord, Neuron, Extracellular Space to Homo sapiens, Spinal cord, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Mu-type opioid receptor (Homo sapiens)_Guanine nucleotide-binding protein G(i) subunit alpha-1 (Homo sapiens)_Gβγ (Homo sapiens)
type: Complex
component stoichiometry: Protein/2036 Presynaptic membrane/Stoichiometry/1.0
component stoichiometry: Protein/4836 Presynaptic membrane/Stoichiometry/1.0
component stoichiometry: ProteinComplex/6637 Presynaptic membrane/Stoichiometry/1.0
cellular location: Presynaptic membrane
component: Mu-type opioid receptor
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Gβγ

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Gamma-aminobutyric acid type B receptor
type: Complex
cellular location: Cell Membrane
component: Gamma-aminobutyric acid type B receptor subunit 1
component: Gamma-aminobutyric acid type B receptor subunit 2

Voltage-dependent N-type calcium channel subunit alpha-1B
type: Protein
cellular location: Presynaptic membrane
entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B

Compound/PW C000041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P63096
organism: BiologicalState789

Reference/PubChem-compound 119
type: UnificationXref
id: 119
db: PubChem-compound

TransportCatalysis5930
type: Catalysis
controller: potassium voltage-gated channel subfamily J
controlled: Transport15981
control type: ACTIVATION

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/UniProt P48544
type: UnificationXref
id: P48544
db: UniProt

Reference/UniProt P48549
type: UnificationXref
id: P48549
db: UniProt

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: γ-Aminobutyric acid

BiologicalState1446
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Spinal cord, Neuron
tissue: Spinal cord

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

potassium voltage-gated channel subfamily J
type: Complex
component: G protein-activated inward rectifier potassium channel 4
component: G protein-activated inward rectifier potassium channel 2
component: G protein-activated inward rectifier potassium channel 3
component: G protein-activated inward rectifier potassium channel 1

Gamma-aminobutyric acid type B receptor subunit 1
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid type B receptor subunit 1

Reference/UniProt Q08462
type: UnificationXref
id: Q08462
db: UniProt

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00334
type: UnificationXref
id: C00334
db: KEGG Compound

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Presynaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042734

TransportCatalysis5713
type: Catalysis
controller: N-type calcium channel
controlled: Transport15179
control type: ACTIVATION

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

N-type calcium channel
type: Complex
cellular location: Presynaptic membrane
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-4
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent N-type calcium channel subunit alpha-1B

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Interaction4046
type: MolecularInteraction
interaction type: direct_interaction
name: Substance P activates Substance P receptor
participant: Substance P
participant: Substance-P receptor

Reference/ChemSpider 23215821
type: UnificationXref
id: 23215821
db: ChemSpider

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/HMDB HMDB0001897
type: UnificationXref
id: HMDB0001897
db: HMDB

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Gamma-aminobutyric acid receptor subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P14867
organism: BiologicalState789

Reference/UniProt P48051
type: UnificationXref
id: P48051
db: UniProt

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Mu-type opioid receptor (Homo sapiens)_Guanine nucleotide-binding protein G(i) subunit alpha-1 (Homo sapiens)_Gβγ (Homo sapiens)
type: Complex
component stoichiometry: Protein/2036 Cytosol/Stoichiometry/1.0
component stoichiometry: ProteinComplex/6637 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/4836 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Mu-type opioid receptor
component: Gβγ

Protein/3418 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit alpha-1
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: BiologicalState789

Substance-P receptor
type: ProteinReference
xref: Reference/UniProt P25103
organism: BiologicalState1446

G protein-activated inward rectifier potassium channel 2
type: Protein
cellular location: Presynaptic membrane
entity reference: G protein-activated inward rectifier potassium channel 2

γ-Aminobutyric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000112
xref: Reference/ChemSpider 116
xref: Reference/PubChem-compound 119
xref: Reference/CAS 56-12-2
xref: Reference/BioCyc 4-AMINO-BUTYRATE
xref: Reference/ChEBI CHEBI 16865
xref: Reference/KEGG Compound C00334
chemical formula: C4H9NO2
molecular weight: 103.06333
structure: ChemicalStructure/PW C000071

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

GABAA receptor
type: Complex
component stoichiometry: Protein/3425 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1864 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/3418 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Gamma-aminobutyric acid receptor subunit beta-2
component: Gamma-aminobutyric acid receptor subunit alpha-1
component: Gamma-aminobutyric acid receptor subunit gamma-2

Gamma-aminobutyric acid receptor subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid receptor subunit alpha-1

Reference/BRENDA TISSUE ONTOLOGY BTO 0001279
type: UnificationXref
id: BTO:0001279
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt O75899
type: UnificationXref
id: O75899
db: UniProt

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Gβ
type: Protein
cellular location: Cytosol
entity reference: Gβ

Gamma-aminobutyric acid receptor subunit beta-2
type: ProteinReference
xref: Reference/UniProt P47870
organism: BiologicalState789

Gamma-aminobutyric acid type B receptor subunit 2
type: ProteinReference
xref: Reference/UniProt O75899
organism: BiologicalState789

Reference/ChEBI CHEBI 16865
type: UnificationXref
id: CHEBI:16865
db: ChEBI

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/UniProt Q9UBS5
type: UnificationXref
id: Q9UBS5
db: UniProt

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Gamma-aminobutyric acid receptor subunit gamma-2
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid receptor subunit gamma-2

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Voltage-dependent N-type calcium channel subunit alpha-1B
type: Protein
entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/PubChem-compound 44359816
type: UnificationXref
id: 44359816
db: PubChem-compound

Reference/HMDB HMDB0000112
type: UnificationXref
id: HMDB0000112
db: HMDB

Reference/ChemSpider 116
type: UnificationXref
id: 116
db: ChemSpider

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Gamma-aminobutyric acid type B receptor subunit 1
type: ProteinReference
xref: Reference/UniProt Q9UBS5
organism: BiologicalState789

Reference/ChemSpider 30841043
type: UnificationXref
id: 30841043
db: ChemSpider

Substance P
type: SmallMoleculeReference
xref: Reference/ChemSpider 23215821
xref: Reference/HMDB HMDB0001897
xref: Reference/ChEBI CHEBI 332416
xref: Reference/CAS 33507-63-0
xref: Reference/PubChem-compound 44359816
chemical formula: C63H98N18O13S
molecular weight: 1346.7281
structure: ChemicalStructure/PW C001265

Pain
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121636
pathway component: SubPathwayInteraction121636
name: SubPathway

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Compound/PW C000071 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Gβγ
type: Complex
cellular location: Cytosol
component: Gβ
component: Gγ

G protein-activated inward rectifier potassium channel 3
type: Protein
cellular location: Presynaptic membrane
entity reference: G protein-activated inward rectifier potassium channel 3

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/UniProt P47870
type: UnificationXref
id: P47870
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Voltage-dependent L-type calcium channel subunit beta-4
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-4

Reference/UniProt P14867
type: UnificationXref
id: P14867
db: UniProt

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Adenylate cyclase type 2
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 2

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

ReactionCatalysis80
type: Catalysis
controller: Adenylate cyclase type 2
controlled: 4.6.1.1
control type: ACTIVATION

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Compound/PW C000071 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Gβγ
type: Complex
cellular location: Presynaptic membrane
component: Gγ
component: Gβ

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

ChemicalStructure/PW C001265
type: ChemicalStructure
structure format: SMILES

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Voltage-dependent L-type calcium channel subunit beta-4
type: Protein
cellular location: Presynaptic membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-4

N-type calcium channel
type: Complex
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent L-type calcium channel subunit beta-4
component: Voltage-dependent N-type calcium channel subunit alpha-1B

Reference/ChEBI CHEBI 332416
type: UnificationXref
id: CHEBI:332416
db: ChEBI

4.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: cAMP
spontaneous: false
EC number: 4.6.1.1
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/UniProt Q92806
type: UnificationXref
id: Q92806
db: UniProt

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Presynaptic membrane
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

G protein-activated inward rectifier potassium channel 4
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 4

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

G protein-activated inward rectifier potassium channel 1
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 1

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/UniProt P63096
type: UnificationXref
id: P63096
db: UniProt

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

G protein-activated inward rectifier potassium channel 1
type: Protein
cellular location: Presynaptic membrane
entity reference: G protein-activated inward rectifier potassium channel 1

Oliceridine
type: SmallMolecule
entity reference: Oliceridine

Protein/1864 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit gamma-2
stoichiometric coefficient: 1.0

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

G protein-activated inward rectifier potassium channel 4
type: Protein
cellular location: Presynaptic membrane
entity reference: G protein-activated inward rectifier potassium channel 4

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

G protein-activated inward rectifier potassium channel 3
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 3

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

G protein-activated inward rectifier potassium channel 2
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 2

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: Reference/UniProt Q00975

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

potassium voltage-gated channel subfamily J
type: Complex
cellular location: Presynaptic membrane
component: G protein-activated inward rectifier potassium channel 2
component: G protein-activated inward rectifier potassium channel 1
component: G protein-activated inward rectifier potassium channel 3
component: G protein-activated inward rectifier potassium channel 4

Gamma-aminobutyric acid receptor subunit gamma-2
type: ProteinReference
xref: Reference/UniProt P18507
organism: BiologicalState789

Reference/UniProt P18507
type: UnificationXref
id: P18507
db: UniProt

Mu-type opioid receptor
type: ProteinReference
xref: Reference/UniProt P35372
organism: BiologicalState789

Gγ
type: Protein
cellular location: Cytosol
entity reference: Gγ

Interaction3354
type: MolecularInteraction
interaction type: direct_interaction
name: γ-Aminobutyric acid activates GABAA receptor
participant: γ-Aminobutyric acid
participant: GABAA receptor

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Protein/2036 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mu-type opioid receptor
stoichiometric coefficient: 1.0

Compound/PW C113712 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oliceridine
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Presynaptic membrane
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Substance P
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Substance P

Reference/UniProt O00305
type: UnificationXref
id: O00305
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Voltage-dependent L-type calcium channel subunit beta-4
type: ProteinReference
xref: Reference/UniProt O00305

Substance-P receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Substance-P receptor

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Oliceridine
type: SmallMolecule
cellular location: Presynaptic membrane
entity reference: Oliceridine

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Adenylate cyclase type 2
type: ProteinReference
xref: Reference/UniProt Q08462
organism: BiologicalState1446

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Synapse
entity reference: γ-Aminobutyric acid

Protein/4836 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(i) subunit alpha-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/UniProt P35372
type: UnificationXref
id: P35372
db: UniProt

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Gγ
type: Protein
cellular location: Presynaptic membrane
entity reference: Gγ

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Oliceridine
type: SmallMoleculeReference
xref: Reference/ChemSpider 30841043
chemical formula: C22H30N2O2S
molecular weight: 386.2028

SubPathwayInteraction121636
type: Interaction
name: SubPathway121636Reaction
name: SubPathwayReaction
participant: cAMP

Gamma-aminobutyric acid receptor subunit beta-2
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid receptor subunit beta-2

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: Reference/UniProt P48549

Mu-type opioid receptor
type: Protein
cellular location: Presynaptic membrane
entity reference: Mu-type opioid receptor

G protein-activated inward rectifier potassium channel 4
type: ProteinReference
xref: Reference/UniProt P48544

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/CAS 56-12-2
type: UnificationXref
id: 56-12-2
db: CAS

Protein/2036 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mu-type opioid receptor
stoichiometric coefficient: 1.0

ProteinComplex/6637 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβγ
stoichiometric coefficient: 1.0

Spinal cord
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001279

Reference/UniProt Q00975
type: UnificationXref
id: Q00975
db: UniProt

Reference/PathWhiz PW128429
type: UnificationXref
id: PW128429
db: PathWhiz

Interaction5221
type: MolecularInteraction
interaction type: direct_interaction
name: Oliceridine activates Mu-type opioid receptor (Homo sapiens) + Guanine nucleotide-binding protein G(i) subunit alpha-1 (Homo sapiens) + Gβγ (Homo sapiens)
participant: Mu-type opioid receptor (Homo sapiens)_Guanine nucleotide-binding protein G(i) subunit alpha-1 (Homo sapiens)_Gβγ (Homo sapiens)
participant: Oliceridine

Reference/BioCyc 4-AMINO-BUTYRATE
type: UnificationXref
id: 4-AMINO-BUTYRATE
db: BioCyc

Gβ
type: Protein
cellular location: Presynaptic membrane
entity reference: Gβ

Mu-type opioid receptor
type: Protein
cellular location: Cytosol
entity reference: Mu-type opioid receptor

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Presynaptic membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Transport16164
type: Transport
participant stoichiometry: Compound/PW C113712 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113712/Stoichiometry/1.0
right: Oliceridine
spontaneous: true
left: Oliceridine
name: Oliceridine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Spinal cord, Neuron, Extracellular Space
conversion direction: REVERSIBLE

Reference/SMPDB SMP0126824
type: UnificationXref
id: SMP0126824
db: SMPDB

Reference/GENE ONTOLOGY GO 0042734
type: UnificationXref
id: GO:0042734
db: GENE ONTOLOGY

ChemicalStructure/PW C000071
type: ChemicalStructure
structure format: SMILES
structure data: NCCCC(O)=O

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Interaction3392
type: MolecularInteraction
interaction type: direct_interaction
name: Mu-type opioid receptor (Homo sapiens) + Guanine nucleotide-binding protein G(i) subunit alpha-1 (Homo sapiens) + Gβγ (Homo sapiens) inhibits N-type calcium channel
participant: Mu-type opioid receptor (Homo sapiens)_Guanine nucleotide-binding protein G(i) subunit alpha-1 (Homo sapiens)_Gβγ (Homo sapiens)
participant: N-type calcium channel

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Interaction3393
type: MolecularInteraction
interaction type: direct_interaction
name: Mu-type opioid receptor (Homo sapiens) + Guanine nucleotide-binding protein G(i) subunit alpha-1 (Homo sapiens) + Gβγ (Homo sapiens) activates potassium voltage-gated channel subfamily J
participant: Mu-type opioid receptor (Homo sapiens)_Guanine nucleotide-binding protein G(i) subunit alpha-1 (Homo sapiens)_Gβγ (Homo sapiens)
participant: potassium voltage-gated channel subfamily J

Interaction3394
type: MolecularInteraction
interaction type: direct_interaction
name: Mu-type opioid receptor (Homo sapiens) + Guanine nucleotide-binding protein G(i) subunit alpha-1 (Homo sapiens) + Gβγ (Homo sapiens) inhibits Adenylate cyclase type 2
participant: Adenylate cyclase type 2
participant: Mu-type opioid receptor (Homo sapiens)_Guanine nucleotide-binding protein G(i) subunit alpha-1 (Homo sapiens)_Gβγ (Homo sapiens)

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

G protein-activated inward rectifier potassium channel 2
type: ProteinReference
xref: Reference/UniProt P48051

Reference/UniProt P25103
type: UnificationXref
id: P25103
db: UniProt

G protein-activated inward rectifier potassium channel 3
type: ProteinReference
xref: Reference/UniProt Q92806

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: γ-Aminobutyric acid

Compound/PW C113712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oliceridine
stoichiometric coefficient: 1.0

Interaction3395
type: MolecularInteraction
interaction type: direct_interaction
name: γ-Aminobutyric acid activates Gamma-aminobutyric acid type B receptor
participant: γ-Aminobutyric acid
participant: Gamma-aminobutyric acid type B receptor

Transport15982
type: Transport
participant stoichiometry: Compound/PW C000071 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Synapse/Stoichiometry/1.0
right: γ-Aminobutyric acid
spontaneous: true
left: γ-Aminobutyric acid
name: γ-Aminobutyric acid (→) Transport: Homo sapiens, Spinal cord, Neuron, Exocytic Vesicle to Homo sapiens, Spinal cord, Neuron, Synapse
conversion direction: REVERSIBLE

Transport15981
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Spinal cord, Neuron, Cytosol to Homo sapiens, Spinal cord, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

ProteinComplex/6637 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβγ
stoichiometric coefficient: 1.0

Gamma-aminobutyric acid type B receptor subunit 2
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid type B receptor subunit 2

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202