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Estrogen sulfotransferase Estradiol 17-beta- dehydrogenase 1 UDP- glucuronosyltransferase 2B11 Cytochrome P450 19A1 Steroid 17-alpha- hydroxylase/17,20 lyase 3-beta-HSD 1 Steroid 17-alpha- hydroxylase/17,20 lyase 3-beta-HSD 1 Sulfotransferase family cytosolic 2B member 1 Cytochrome P450 19A1 Testosterone 17-beta- dehydrogenase 3 3-oxo-5-beta- steroid 4-dehydrogenase 3-oxo-5- alpha-steroid 4-dehydrogenase 1 UDP- glucuronosyltransferase 2B17 Steryl- sulfatase 17-Hydroxyprogesterone 17a-Hydroxypregnenolone Estrone Phosphoadenosine phosphosulfate Estrone sulfate Adenosine 3',5'-diphosphate 19-Oxoandrost-4-ene-3,17-dione Estradiol NADP NADPH 19-Oxotestosterone 19-Hydroxyandrost-4-ene- 3,17-dione 19-Hydroxytestosterone Uridine diphosphate glucuronic acid 17-β-Estradiol-3-glucuronide Uridine 5'-diphosphate Accumulation Androstenedione O2 H2O NAD NADH Accumulation Dehydroepiandrosterone NAD NADH Phosphoadenosine phosphosulfate Adenosine 3',5'-diphosphate Dehydroepiandrosterone sulfate Testosterone O2 H2O NAD NADH H+ 5b-Dihydrotestosterone Dihydrotestosterone NADP NADPH H+ Testosterone glucuronide H2O Sulfate Heme Heme Heme Reduced flavoprotein Oxidized flavoprotein Steroidogenesis Calcium Heme ER Membrane ER Membrane Cytoplasm ER Lumen ER Lumen Smooth Endoplasmic Reticulum Intracellular Space Extracellular Space
Endoplasmic Reticulum SULT1E1 HSD17B1 UGT2B11 CYP19A1 CYP17A1 HSD3B1 CYP17A1 HSD3B1 SULT2B1 CYP19A1 HSD17B3 AKR1D1 SRD5A1 UGT2B17 STS 17- Hydroxyprogesterone 17a- Hydroxypregnenolone Estrone Phosphoadenosine phosphosulfate Estrone sulfate Adenosine 3',5'- diphosphate 19- Oxoandrost-4- ene-3,17- dione Estradiol NADP NADPH 19- Oxotestosterone 19- Hydroxyandrost- 4-ene-3,17- dione 19- Hydroxytestosterone Uridine diphosphate glucuronic acid 17-β- Estradiol-3- glucuronide Uridine 5'-diphosphate Accumulation Androstenedione Oxygen Water NAD NADH Accumulation Dehydroepiandrosterone NAD NADH Phosphoadenosine phosphosulfate Adenosine 3',5'- diphosphate Dehydroepiandrosterone sulfate Testosterone Oxygen Water NAD NADH Hydrogen Ion 5b- Dihydrotestosterone Dihydrotestosterone NADP NADPH Hydrogen Ion Testosterone glucuronide Water Sulfate Reduced flavoprotein Oxidized flavoprotein Steroidogenesis
SULT1E1 HSD17B1 UGT2B11 CYP19A1 CYP17A1 HSD3B1 CYP17A1 HSD3B1 SULT2B1 CYP19A1 HSD17B3 AKR1D1 SRD5A1 UGT2B17 STS 17-OHP 17a-HP Estrone Paps Estrone A3'5'PP 19O4e Estdiol NADP NADPH 19OTest 19-Haon 19-Htes UDPGlcA 17βE3G UDP Accumulation Adione O2 H2O NAD NADH Accumulation DHEA NAD NADH Paps A3'5'PP DHEASS Oreton O2 H2O NAD NADH H+ 5b-Dhtt DHT NADP NADPH H+ TesGluA H2O SO4 Heme Heme Heme RF OF PW000141 Ca2+ Heme ER Membrane ER Membrane Cytoplasm ER Lumen ER Lumen Smooth Endoplasmic Reticulum Intracellular Space Extracellular Space
Endoplasmic Reticulum SULT1E1 HSD17B1 UGT2B11 CYP19A1 CYP17A1 HSD3B1 CYP17A1 HSD3B1 SULT2B1 CYP19A1 HSD17B3 AKR1D1 SRD5A1 UGT2B17 STS 17-OHP 17a-HP Estrone Paps Estrone A3'5'PP 19O4e Estdiol NADP NADPH 19OTest 19-Haon 19-Htes UDPGlcA 17βE3G UDP Accumulation Adione O2 H2O NAD NADH Accumulation DHEA NAD NADH Paps A3'5'PP DHEASS Oreton O2 H2O NAD NADH H+ 5b-Dhtt DHT NADP NADPH H+ TesGluA H2O SO4 RF OF PW000141