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Aldo-keto reductase family 1 member C4 3-oxo-5-beta- steroid 4-dehydrogenase Cytochrome P450 11B2, mitochondrial Cytochrome P450 11B1, mitochondrial Aldo-keto reductase family 1 member C4 Corticosteroid 11-beta- dehydrogenase isozyme 1 Aldo-keto reductase family 1 member C4 Steroid 21-hydroxylase Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase Cytochrome P450 11B1, mitochondrial 3-beta-HSD 1 Steroid 21-hydroxylase 3-beta-HSD 1 Cytochrome P450 11B2, mitochondrial Steroid 21-hydroxylase Cytochrome P450 11B1, mitochondrial Cytochrome P450 11B1, mitochondrial Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase 3-beta-HSD 1 3-beta-HSD 1 Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Steroid 17-alpha- hydroxylase/17,20 lyase 3-oxo-5-beta- steroid 4-dehydrogenase Aldo-keto reductase family 1 member C4 3-oxo-5-beta- steroid 4-dehydrogenase Aldo-keto reductase family 1 member C4 Cytochrome P450 11B1, mitochondrial 3-oxo-5-beta- steroid 4-dehydrogenase Aldo-keto reductase family 1 member C4 Corticosteroid 11-beta- dehydrogenase isozyme 2 Corticosteroid 11-beta- dehydrogenase isozyme 2 3 beta- hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 Cholesterol Progesterone Progesterone 11b,21-Dihydroxy-3,20-oxo- 5b-pregnan-18-al NADPH 3a,11b,21-Trihydroxy-20-oxo- 5b-pregnan-18-al NADP NADP Aldosterone NADPH 18-Hydroxycorticosterone O2 H2O Corticosterone O2 H2O 11b,21-Dihydroxy-5b- pregnane-3,20-dione Tetrahydrocorticosterone NADP NADPH 11-Dehydrocorticosterone 21-Hydroxy-5b-pregnane- 3,11,20-trione NADP 3a,21-Dihydroxy-5b-pregnane- 11,20-dione NADPH NADP NADPH 11b-Hydroxyprogesterone 21-Deoxycortisol Cortisol Deoxycorticosterone 21-Hydroxypregnenolone NAD NADH Pregnenolone NAD NADH 17-Hydroxyprogesterone Cortexolone 17a-Hydroxypregnenolone NAD NADH NADH 17α,21-Dihydroxypregnenolone NAD 20a,22b-Dihydroxycholesterol 4-Methylpentanal 17a,20a-Dihydroxycholesterol 22b-Hydroxycholesterol 20α-Hydroxycholesterol 17a,21-Dihydroxy-5b- pregnane-3,11,20-trione NADP Cortisone NADPH Tetrahydrocortisone NADP NADPH Dihydrocortisol NADP NADPH Tetrahydrocortisol NADP NADPH O2 11b,17a,21-Trihydroxypreg- nenolone H2O NADPH 5a-Pregnane-3,20-dione NADP 3a-Hydroxy-5b-pregnane-20-one NADP NADPH NADP NADPH Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Steroid Biosynthesis