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Amiloride-
sensitive
sodium channel
subunit alpha
Amiloride-
sensitive
sodium channel
subunit beta
Amiloride-
sensitive
sodium channel
subunit delta
Amiloride-
sensitive
sodium channel
subunit gamma
Sodium/potassium-
transporting
ATPase subunit
alpha-1
Sodium/potassium-
transporting
ATPase subunit
alpha-2
Sodium/potassium-
transporting
ATPase subunit
alpha-3
Sodium/potassium-
transporting
ATPase subunit
alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-1
Sodium/potassium-
transporting
ATPase subunit
beta-2
Sodium/potassium-
transporting
ATPase subunit
beta-3
ATPase,
(Na+)/K+
transporting,
beta 4
polypeptide
Sodium/potassium-
transporting
ATPase subunit
gamma
Solute carrier
family 12
member 3
Sodium/potassium-
transporting
ATPase subunit
alpha-1
Sodium/potassium-
transporting
ATPase subunit
alpha-2
Sodium/potassium-
transporting
ATPase subunit
alpha-3
Sodium/potassium-
transporting
ATPase subunit
alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-1
Sodium/potassium-
transporting
ATPase subunit
beta-2
Sodium/potassium-
transporting
ATPase subunit
beta-3
ATPase,
(Na+)/K+
transporting,
beta 4
polypeptide
Sodium/potassium-
transporting
ATPase subunit
gamma
Chloride
channel protein
ClC-Ka
Solute carrier
family 12
member 1
Chloride
channel protein
ClC-Ka
Solute carrier
family 22
member 6
Sodium/potassium-
transporting
ATPase subunit
alpha-1
Sodium/potassium-
transporting
ATPase subunit
alpha-2
Sodium/potassium-
transporting
ATPase subunit
alpha-3
Sodium/potassium-
transporting
ATPase subunit
alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-1
Sodium/potassium-
transporting
ATPase subunit
beta-2
Sodium/potassium-
transporting
ATPase subunit
beta-3
ATPase,
(Na+)/K+
transporting,
beta 4
polypeptide
Sodium/potassium-
transporting
ATPase subunit
gamma
Solute carrier
family 12
member 6
Solute carrier
family 22
member 2
Amiloride-
sensitive
sodium channel
subunit alpha
Amiloride-
sensitive
sodium channel
subunit beta
Amiloride-
sensitive
sodium channel
subunit delta
Amiloride-
sensitive
sodium channel
subunit gamma
Sodium/potassium-
transporting
ATPase subunit
alpha-1
Sodium/potassium-
transporting
ATPase subunit
alpha-2
Sodium/potassium-
transporting
ATPase subunit
alpha-3
Sodium/potassium-
transporting
ATPase subunit
alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-1
Sodium/potassium-
transporting
ATPase subunit
beta-2
Sodium/potassium-
transporting
ATPase subunit
beta-3
ATPase,
(Na+)/K+
transporting,
beta 4
polypeptide
Sodium/potassium-
transporting
ATPase subunit
gamma
Excitatory
amino acid
transporter 3
Large neutral
amino acids
transporter
small subunit 1
4F2
cell-surface
antigen heavy
chain
Sodium- and
chloride-
dependent
transporter
XTRP3
Sodium-coupled
neutral amino
acid
transporter 4
Y+L amino acid
transporter 1
4F2
cell-surface
antigen heavy
chain
Y+L amino acid
transporter 2
4F2
cell-surface
antigen heavy
chain
Neutral and
basic amino
acid transport
protein rBAT
B(0,+)-type
amino acid
transporter 1
Urea
transporter 2
Large neutral
amino acids
transporter
small subunit 2
4F2
cell-surface
antigen heavy
chain
Aquaporin-1
ATP-sensitive
inward
rectifier
potassium
channel 1
ATP-sensitive
inward
rectifier
potassium
channel 1
Aquaporin-1
Aquaporin-2
Aquaporin-3
Mineralocorticoid
receptor
Cl
-
Cl
-
Na
+
Na
+
Na
+
K
+
K
+
Cl
-
Cl
-
Na
+
Na
+
K
+
K
+
Cl
-
Cl
-
Cl
-
Cl
-
Na
+
K
+
K
+
Cl
-
Cl
-
K
+
K
+
Na
+
Na
+
Na
+
Na
+
K
+
K
+
Na
+
Na
+
Na
+
Na
+
Cl
-
Cl
-
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Hydrogen
carbonate
Hydrogen
carbonate
Hydrogen
carbonate
Hydrogen
carbonate
L-Cysteine
L-Cysteine
Urea
Urea
H
2
O
H
2
O
K
+
K
+
K
+
K
+
H
2
O
H
2
O
H
2
O
H
2
O
Aldosterone
Organic Anion
Organic Anion
Organic Cation
Organic Cation
L-Amino acid
L-Amino acid
Large Neutral
Amino Acids
Large Neutral
Amino Acids
Imino acids
Imino acids
L-Amino acid
L-Amino acid
L-Amino acid
L-Amino acid
L-Amino acid
L-Amino acid
Large Neutral
Amino Acids
Large Neutral
Amino Acids
Transcription/Translation
PROXIMAL CONVOLUTED TUBULE
LUMEN
INTERSTITIUM
DISTAL CONVOLUTED TUBULE
LUMEN
INTERSTITIUM
DESCENDING LIMB OF LOOP OF
HENLE
LUMEN
INTERSTITIUM
THICK ASCENDING LIMB OF LOOP
OF HENLE
LUMEN
LUMEN
INTERSTITIUM
COLLECTING TUBULE
INTERSTITIUM
Nucleus
SCNN1A
SCNN1B
SCNN1D
SCNN1G
ATP1A1
ATP1A2
ATP1A3
ATP1A4
ATP1B1
ATP1B2
ATP1B3
Unknown
FXYD2
SLC12A3
ATP1A1
ATP1A2
ATP1A3
ATP1A4
ATP1B1
ATP1B2
ATP1B3
Unknown
FXYD2
CLCNKA
SLC12A1
CLCNKA
SLC22A6
ATP1A1
ATP1A2
ATP1A3
ATP1A4
ATP1B1
ATP1B2
ATP1B3
Unknown
FXYD2
SLC12A6
SLC22A2
SCNN1A
SCNN1B
SCNN1D
SCNN1G
ATP1A1
ATP1A2
ATP1A3
ATP1A4
ATP1B1
ATP1B2
ATP1B3
Unknown
FXYD2
SLC1A1
SLC7A5
SLC3A2
SLC6A20
SLC38A4
SLC7A7
SLC3A2
SLC7A6
SLC3A2
SLC3A1
SLC7A9
SLC14A2
SLC7A8
SLC3A2
AQP1
KCNJ1
KCNJ1
AQP1
AQP2
AQP3
NR3C2
Chloride ion
Chloride ion
Sodium
Sodium
Sodium
Potassium
Potassium
Chloride ion
Chloride ion
Sodium
Sodium
Potassium
Potassium
Chloride ion
Chloride ion
Chloride ion
Chloride ion
Sodium
Potassium
Potassium
Chloride ion
Chloride ion
Potassium
Potassium
Sodium
Sodium
Sodium
Sodium
Potassium
Potassium
Sodium
Sodium
Sodium
Sodium
Chloride ion
Chloride ion
Sodium
Sodium
Sodium
Sodium
Sodium
Sodium
Hydrogen
carbonate
Hydrogen
carbonate
Hydrogen
carbonate
Hydrogen
carbonate
L-Cysteine
L-Cysteine
Urea
Urea
Water
Water
Potassium
Potassium
Potassium
Potassium
Water
Water
Water
Water
Aldosterone
Organic Anion
Organic Anion
Organic Cation
Organic Cation
L-Amino acid
L-Amino acid
Large Neutral
Amino Acids
Large Neutral
Amino Acids
Imino acids
Imino acids
L-Amino acid
L-Amino acid
L-Amino acid
L-Amino acid
L-Amino acid
L-Amino acid
Large Neutral
Amino Acids
Large Neutral
Amino Acids
Transcription/Translation
SCNN1A
SCNN1B
SCNN1D
SCNN1G
ATP1A1
ATP1A2
ATP1A3
ATP1A4
ATP1B1
ATP1B2
ATP1B3
FXYD2
SLC12A3
ATP1A1
ATP1A2
ATP1A3
ATP1A4
ATP1B1
ATP1B2
ATP1B3
FXYD2
CLCNKA
SLC12A1
CLCNKA
SLC22A6
ATP1A1
ATP1A2
ATP1A3
ATP1A4
ATP1B1
ATP1B2
ATP1B3
FXYD2
SLC12A6
SLC22A2
SCNN1A
SCNN1B
SCNN1D
SCNN1G
ATP1A1
ATP1A2
ATP1A3
ATP1A4
ATP1B1
ATP1B2
ATP1B3
FXYD2
SLC1A1
SLC7A5
SLC3A2
SLC6A20
SLC38A4
SLC7A7
SLC3A2
SLC7A6
SLC3A2
SLC3A1
SLC7A9
SLC14A2
SLC7A8
SLC3A2
AQP1
KCNJ1
KCNJ1
AQP1
AQP2
AQP3
NR3C2
Cl
-
Cl
-
Na
+
Na
+
Na
+
K
+
K
+
Cl
-
Cl
-
Na
+
Na
+
K
+
K
+
Cl
-
Cl
-
Cl
-
Cl
-
Na
+
K
+
K
+
Cl
-
Cl
-
K
+
K
+
Na
+
Na
+
Na
+
Na
+
K
+
K
+
Na
+
Na
+
Na
+
Na
+
Cl
-
Cl
-
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
HCO3
HCO3
HCO3
HCO3
Cys
Cys
Urea
Urea
H
2
O
H
2
O
K
+
K
+
K
+
K
+
H
2
O
H
2
O
H
2
O
H
2
O
Aldostr
OA
OA
OC
OC
LAA
LAA
LNAA
LNAA
IA
IA
LAA
LAA
LAA
LAA
LAA
LAA
LNAA
LNAA
PW000455