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Pathway Description
Old Atorvastatin Action Pathway
Homo sapiens
Drug Action Pathway
Atorvastatin is a medication used to lower “bad cholesterol.” It is commonly sold as Lipitor. It is part of the drug class called “statins.” Having high levels of “bad cholesterol” can lead to heart attack or stroke, and is usually caused by poor dietary habits. Atorvastatin works by inhibiting the production of cholesterol that is created in the liver. It inhibits an enzyme called hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme is responsible for converting HMG-CoA into mevalonic acid. This conversion is one of the reactions in the chain of reactions that metabolizes lipids and transports lipids. This drug was approved by the FDA in 1996.
References
Old Atorvastatin Pathway References
Lipitor. (2009). e-CPS (online version of Compendium of Pharmaceuticals and Specialties). Retrieved June 30, 2009.
Reszka AA, Rodan GA: Bisphosphonate mechanism of action. Curr Rheumatol Rep. 2003 Feb;5(1):65-74.
Pubmed: 12590887
Schmidt, E.B., & Larsen, M.L. HMG-CoA-reductase-inhibitors. In S. Offermanns, & W. Rosenthal (Eds.). Encyclopedic reference of molecular pharmacology (2004);p. 460-463. Berlin, Germany: Springer.
Steroid Biosynthesis References
Lehninger, A.L. Lehninger principles of biochemistry (4th ed.) (2005). New York: W.H Freeman.
Norman, A.W, and Litwack, G. Hormones (2nd ed.) (1997) San Diego : Academic Press.
Salway, J.G. Metabolism at a glance (3rd ed.) (2004). Alden, Mass.: Blackwell Pub.
Vance, D.E., and Vance, J.E. Biochemistry of lipids, lipoproteins, and membranes (4th ed.) (2002) Amsterdam; Boston: Elsevier.
Simons J: The $10 billion pill. Fortune. 2003 Jan 20;147(1):58-62, 66, 68.
Pubmed: 12602122
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