Amiloride is a diuretic that inhibits the sodium channels in the late distal convoluted tubule and collecting tube of the nephron where 1-2% of sodium reabsorption occurs. The inhibition of sodium reabsorption results in increased osmolarity in the lumen and decreased osmolarity in the interstitium of the nephron. This decreased osmotic gradient results in a modest diuresis. The drug is also potassium sparing. Potassium is typically excreted due to the electrochemical gradient produced by sodium reabsorption. Therefore, amiloride's inhibition of sodium reabsorption fails to produce an electrochemical gradient and therefore, inhibits potassium excretion. Amiloride causes an increase in sodium excretion and a decrease in potassium secretion. The drug is typically prescribed to patients with depleted potassium.

Amiloride Pathway References

Kidney Function References