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Pathway Description
Atenolol Action Pathway
Homo sapiens
Drug Action Pathway
Atenolol, trade name Tenormin, is a beta blocker prescribed to treat hypertension. Atenolol is a selective beta-1-adrenoceptor antagonist targeting the heart and vascular smooth muscle to inhibit sympathetic activity. Binding of atenolol inhibits the G protein signalling cascade and reduces heart rate, blood pressure, cardiac output and reflex orthostatic hypotension. Beta blockers were once the first line therapy for hypertension, however, current recommendations favour calcium channel blockers and angiotensin converting enzyme inhibitors.
References
Atenolol Pathway References
Borchard, U. Pharmacological properties of beta-adrenoceptor blocking drugs. Journal of Clinical and Basic Cardiology. 1998;1(1):5-9.
DiPiro, J.T., Talbert, R.L., Yee, G.C., Matzke, G.R., Wells, B.G, & Posey, M.L. Pharmacotherapy: A pathologic approach. (6th ed) (2005) p.207-208. New York: McGraw-Hill Medical Publishing Division.
Tenormin. (2009). e-CPS (online version of Compendium of Pharmaceuticals and Specialties). Retrieved July 25, 2009.
Carlberg B, Samuelsson O, Lindholm LH: Atenolol in hypertension: is it a wise choice? Lancet. 2004 Nov 6-12;364(9446):1684-9. doi: 10.1016/S0140-6736(04)17355-8.
Pubmed: 15530629
Wadworth AN, Murdoch D, Brogden RN: Atenolol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders. Drugs. 1991 Sep;42(3):468-510. doi: 10.2165/00003495-199142030-00007.
Pubmed: 1720383
Ripley TL, Saseen JJ: beta-blockers: a review of their pharmacological and physiological diversity in hypertension. Ann Pharmacother. 2014 Jun;48(6):723-33. doi: 10.1177/1060028013519591. Epub 2014 Mar 31.
Pubmed: 24687542
Striated Muscle Contraction References
Cooke R: The sliding filament model: 1972-2004. J Gen Physiol. 2004 Jun;123(6):643-56. doi: 10.1085/jgp.200409089.
Pubmed: 15173218
Szent-Gyorgyi A: The mechanism of muscle contraction. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3343-4.
Pubmed: 4610574
Kuo IY, Ehrlich BE: Signaling in muscle contraction. Cold Spring Harb Perspect Biol. 2015 Feb 2;7(2):a006023. doi: 10.1101/cshperspect.a006023.
Pubmed: 25646377
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