PathWhiz

Pathway Description

Propranolol Action Pathway

Homo sapiens

Drug Action Pathway

Propranolol, a non-cardioselective beta blocker, inhibits sympathetic stimulation by competing with neurotransmitters like catecholamines to bind beta(1)-adrenergic receptors of the heart and vascular smooth muscle. Propranolol binding reduces resting heart rate, cardiac output, blood pressure and orthostatic hypotension. Propranolol also reduce sympathetic activity to manage hyperthyroidism, anxiety and tremor. Propranolol also competes for beta(2)-adrenergic receptors on bronchial and vascular smooth muscles.

References

Propranolol Pathway References

Borchard, U. Pharmacological properties of beta-adrenoceptor blocking drugs. Journal of Clinical and Basic Cardiology. 1998;1(1):5-9.

DiPiro, J.T., Talbert, R.L., Yee, G.C., Matzke, G.R., Wells, B.G, & Posey, M.L. Pharmacotherapy: A pathologic approach. (6th ed) (2005) p.207-208. New York: McGraw-Hill Medical Publishing Division.

Propranolol. (2009). e-CPS (online version of Compendium of Pharmaceuticals and Specialties). Retrieved July 25, 2009.

Al-Majed AA, Bakheit AHH, Abdel Aziz HA, Alajmi FM, AlRabiah H: Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. doi: 10.1016/bs.podrm.2017.02.006. Epub 2017 Apr 6.

Pubmed: 28431779

Lopez-Sendon J, Swedberg K, McMurray J, Tamargo J, Maggioni AP, Dargie H, Tendera M, Waagstein F, Kjekshus J, Lechat P, Torp-Pedersen C: Expert consensus document on beta-adrenergic receptor blockers. Eur Heart J. 2004 Aug;25(15):1341-62. doi: 10.1016/j.ehj.2004.06.002.

Pubmed: 15288162

Striated Muscle Contraction References

Cooke R: The sliding filament model: 1972-2004. J Gen Physiol. 2004 Jun;123(6):643-56. doi: 10.1085/jgp.200409089.

Pubmed: 15173218

Szent-Gyorgyi A: The mechanism of muscle contraction. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3343-4.

Pubmed: 4610574

Kuo IY, Ehrlich BE: Signaling in muscle contraction. Cold Spring Harb Perspect Biol. 2015 Feb 2;7(2):a006023. doi: 10.1101/cshperspect.a006023.

Pubmed: 25646377

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine triphosphate
		Calcium
		Phosphate
		Potassium
		Propranolol
		Sodium
		Water

Visualize Protein Data

		Alpha-1-syntrophin
		ATP-binding cassette sub-family C member 8
		ATP-binding cassette sub-family C member 9
		ATP-sensitive inward rectifier potassium channel 11
		ATP-sensitive inward rectifier potassium channel 8
		ATPase, (Na+)/K+ transporting, beta 4 polypeptide
		Beta-1 adrenergic receptor
		Beta-1-syntrophin
		Beta-2-syntrophin
		cAMP-dependent protein kinase catalytic subunit alpha
		cAMP-dependent protein kinase type I-alpha regulatory subunit
		Cardiac phospholamban
		Disks large homolog 1
		G protein-activated inward rectifier potassium channel 1
		G protein-activated inward rectifier potassium channel 4
		Inward rectifier potassium channel 2
		Inward rectifier potassium channel 4
		Kv channel-interacting protein 2
		Muscarinic acetylcholine receptor M2
		Potassium channel subfamily K member 1
		Potassium voltage-gated channel subfamily A member 5
		Potassium voltage-gated channel subfamily D member 3
		Potassium voltage-gated channel subfamily E member 1
		Potassium voltage-gated channel subfamily E member 2
		Potassium voltage-gated channel subfamily H member 2
		Potassium voltage-gated channel subfamily KQT member 1
		Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
		Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
		Ryanodine receptor 2
		Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
		Sodium channel protein type 5 subunit alpha
		Sodium/calcium exchanger 1
		Sodium/potassium-transporting ATPase subunit alpha-1
		Sodium/potassium-transporting ATPase subunit alpha-2
		Sodium/potassium-transporting ATPase subunit alpha-3
		Sodium/potassium-transporting ATPase subunit alpha-4
		Sodium/potassium-transporting ATPase subunit beta-1
		Sodium/potassium-transporting ATPase subunit beta-2
		Sodium/potassium-transporting ATPase subunit beta-3
		Sodium/potassium-transporting ATPase subunit gamma
		Tropomyosin alpha-1 chain
		Tropomyosin beta chain
		Voltage-dependent calcium channel subunit alpha-2/delta-2
		Voltage-dependent L-type calcium channel subunit alpha-1C
		Voltage-dependent L-type calcium channel subunit beta-1
		Voltage-dependent T-type calcium channel subunit alpha-1G
		Voltage-dependent T-type calcium channel subunit alpha-1H

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