Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Prednisone Action Pathway
Homo sapiens
Drug Action Pathway
Prednisone is a medication that is used to suppress the immune system. It works by interrupting cytokine pathways type 1 and type 2. It is administered orally, through tablet, or solution (concentrated or non-concentrated). Prednisone is a glucocorticoid, and as well as being used for immune system suppression, it is used for its anti inflammatory properties. It exerts these properties by binding to glucocorticoid receptors in the cell, which inhibits inflammatory cells. This prevents inflammatory mediators from being expressed.
References
Prednisone Pathway References
Barnes PJ, Adcock IM: Glucocorticoid resistance in inflammatory diseases. Lancet. 2009 May 30;373(9678):1905-17. doi: 10.1016/S0140-6736(09)60326-3.
Pubmed: 19482216
Frey BM, Frey FJ: Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1990 Aug;19(2):126-46. doi: 10.2165/00003088-199019020-00003.
Pubmed: 2199128
Pujolsa L, Mullol J, Picado C: Glucocorticoid receptor in human respiratory epithelial cells. Neuroimmunomodulation. 2009;16(5):290-9. doi: 10.1159/000216187. Epub 2009 Jun 29.
Pubmed: 19571590
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Settings