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Pathway Description
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Homo sapiens
Protein Pathway
The 5-HT7 receptor is primarily found in the CNS, GI tract, and blood vessels. Serotonin is the primary ligand of the 5-HT7 receptor, which activates G(s) proteins associated with the receptor and leads to the activation of adenylyl cyclase and production of the secondary messenger cyclic adenosine monophosphate (cAMP). cAMP activates protein kinase A, phosphorylating downstream effectors that lead to specific cellular responses which mediate physiological functions such as thermoregulation, circadian rhythm, learning and memory, sleep, and potentially mood.
References
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin References
Bard JA, Zgombick J, Adham N, Vaysse P, Branchek TA, Weinshank RL: Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6.
Pubmed: 8226867
Hedlund PB, Sutcliffe JG: Functional, molecular and pharmacological advances in 5-HT7 receptor research. Trends Pharmacol Sci. 2004 Sep;25(9):481-6. doi: 10.1016/j.tips.2004.07.002.
Pubmed: 15559250
Krauss, G. Biochemistry of signal transduction and regulation. (3rd ed.) (2003) Weinheim; New York : Wiley-VCH
Ruat M, Traiffort E, Leurs R, Tardivel-Lacombe J, Diaz J, Arrang JM, Schwartz JC: Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8547-51. doi: 10.1073/pnas.90.18.8547.
Pubmed: 8397408
Vanhoenacker P, Haegeman G, Leysen JE: 5-HT7 receptors: current knowledge and future prospects. Trends Pharmacol Sci. 2000 Feb;21(2):70-7.
Pubmed: 10664612
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