PathWhiz

Pathway Description

Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

Homo sapiens

Protein Pathway

A member of the G-coupled protein receptor family, the adenosine A2A receptor regulates blood flow to myocardial tissues through the action of vasodilating the coronary arteries, which can potentially lead to hypotension. The adenosine receptor A2a activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response. This occurs through activation of the MAPK/ERK signaling cascade. The A2A receptor has also been demonstrated to play a role in dopamine and glutamate release in the CNS.

References

Intracellular Signalling Through Adenosine Receptor A2a and Adenosine References

Giaime P, Carrega L, Fenouillet E, Mercier L, Gerolami V, Ruf J, Sauze N, Brunet P, Saadjian A, Berland Y, Dussol B, Guieu R: Relationship between A2A adenosine receptor expression and intradialytic hypotension during hemodialysis. J Investig Med. 2006 Dec;54(8):473-7. doi: 10.2310/6650.2006.06005.

Pubmed: 17169272

Jacobson KA, Gao ZG: Adenosine receptors as therapeutic targets. Nat Rev Drug Discov. 2006 Mar;5(3):247-64. doi: 10.1038/nrd1983.

Pubmed: 16518376

Zhao J, Deng Y, Jiang Z, Qing H: G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs. Front Aging Neurosci. 2016 Mar 24;8:58. doi: 10.3389/fnagi.2016.00058. eCollection 2016.

Pubmed: 27047374

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine
		Adenosine triphosphate
		cAMP
		Guanosine diphosphate
		Guanosine triphosphate
		Magnesium
		Phosphate
		PIP2(16:0/16:0)
		PIP3(16:0/16:0)
		Pyrophosphate
		Zinc

Visualize Protein Data

		3-phosphoinositide-dependent protein kinase 1
		Adenosine receptor A2a
		Adenylate cyclase type 2
		Bcl2-associated agonist of cell death
		cAMP-dependent protein kinase catalytic subunit beta
		Cell division control protein 42 homolog
		Cyclic AMP-dependent transcription factor ATF-2
		Cyclic AMP-responsive element-binding protein 1
		Dual specificity mitogen-activated protein kinase kinase 2
		Dual specificity mitogen-activated protein kinase kinase 6
		Dual specificity mitogen-activated protein kinase kinase 7
		ETS domain-containing protein Elk-1
		GTPase HRas
		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
		Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
		Gβ
		Inhibitor of nuclear factor kappa-B kinase subunit alpha
		Inhibitor of nuclear factor kappa-B kinase subunit beta
		Mitogen-activated protein kinase 1
		Mitogen-activated protein kinase 11
		Mitogen-activated protein kinase 8
		Mitogen-activated protein kinase kinase kinase 1
		Mitogen-activated protein kinase kinase kinase 4
		NF-kappa-B inhibitor alpha
		Nuclear factor NF-kappa-B p100 subunit
		Nuclear factor NF-kappa-B p105 subunit
		Partitioning defective 6 homolog alpha
		Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
		Protein kinase C zeta type
		RAC-alpha serine/threonine-protein kinase
		Rap guanine nucleotide exchange factor 2
		Rap guanine nucleotide exchange factor 3
		Ras-related protein Rap-1A
		Rho guanine nucleotide exchange factor 7
		Ribosomal protein S6 kinase alpha-1
		Serine/threonine-protein kinase B-raf
		Serine/threonine-protein kinase PAK 1
		Transcription factor AP-1

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