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Pathway Description
Vasopressin Regulation of Water Homeostasis
Homo sapiens
Protein Pathway
The vasopressin V2 receptor is found in the kidneys. It serves a role in maintaining corporal water homeostasis. Malfunction of this receptor can lead to Nephrogenic Diabetes Insipidus.
Vasopressin (aka Antidiuretic hormone) activates both follicle-stimulating hormone receptor as well as the V2 receptor G protein complex. From this complex, Guanine nucleotide binding protein G(s) protein reacts with Adenylate Cyclase Type 2, Adeonsine Triphosphate, as well as GTP and magnesium to produce cAMP and Pyrophosphate. cAMP then activates PKA (protein kinase A) which leads to changes in the concentration of water in urine.
References
Vasopressin Regulation of Water Homeostasis References
Innamorati G, Sadeghi H, Eberle AN, Birnbaumer M: Phosphorylation of the V2 vasopressin receptor. J Biol Chem. 1997 Jan 24;272(4):2486-92.
Pubmed: 8999963
Krauss, G. Biochemistry of signal transduction and regulation. (3rd ed.) (2003) Weinheim; New York : Wiley-VCH
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