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Histamine H2 receptor Gastrin Gastrin/cholecystokinin type B receptor Muscarinic acetylcholine receptor M3 Potassium- transporting ATPase subunit beta Potassium- transporting ATPase alpha chain 1 Somatostatin Somatostatin receptor type 2 Chloride intracellular channel protein 2 Carbonic anhydrase 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 2 Histamine Acetylcholine Cl- Cl- HCO3- H2O CO2 H+ K+ K+ ATP H2O ADP Pi H+ Zinc (II) ion G-Protein Signaling Cascade Stomach Lumen Gastric Parietal Cell Gastric Parietal Cell Interstitial Fluid Stomach Lumen Capillary From G cells in antrum stomach From enterochromaffin-like (ECL) cells in the body and fundus of the stomach From intramural neurons in the antrum, body, and fundus of the stomach From D cells in the antrum, body, and fundus of the stomach Chloride ion from blood circulation Hydrogen carbonate (bicarbonate) ion to blood circulation
HRH2 Unknown CCKBR CHRM3 ATP4B ATP4A SST SSTR2 CLIC2 CA1 KCNQ1 KCNE2 Histamine Acetylcholine Chloride ion Chloride ion Hydrogen carbonate Water Carbon dioxide Hydrogen Ion Potassium Potassium Adenosine triphosphate Water Adenosine diphosphate Phosphate Hydrogen Ion G-Protein Signaling Cascade