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Pathway Description
Prednisone Metabolism Pathway
Homo sapiens
Drug Metabolism Pathway
Prednisone is a medication that is used to suppress the immune system. It works by interrupting cytokine pathways type 1 and type 2. It is administered orally, through tablet, or solution (concentrated or non-concentrated). Prednisone is a glucocorticoid, and as well as being used for immune system suppression, it is used for its anti inflammatory properties. It exerts these properties by binding to glucocorticoid receptors in the cell, which inhibits inflammatory cells. This prevents inflammatory mediators from being expressed.
References
Prednisone Pathway References
Barnes PJ, Adcock IM: Glucocorticoid resistance in inflammatory diseases. Lancet. 2009 May 30;373(9678):1905-17. doi: 10.1016/S0140-6736(09)60326-3.
Pubmed: 19482216
Frey BM, Frey FJ: Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1990 Aug;19(2):126-46. doi: 10.2165/00003088-199019020-00003.
Pubmed: 2199128
Pujolsa L, Mullol J, Picado C: Glucocorticoid receptor in human respiratory epithelial cells. Neuroimmunomodulation. 2009;16(5):290-9. doi: 10.1159/000216187. Epub 2009 Jun 29.
Pubmed: 19571590
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