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Sodium- dependent noradrenaline transporter Sodium- dependent serotonin transporter Multidrug resistance protein 1 Cytochrome P450 2D6 Cytochrome P450 2C19 Cytochrome P450 2C19 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 2C19 Cytochrome P450 2C19 Cytochrome P450 2D6 Venlafaxine O-Desmethylvenlafaxine O-Desmethylvenlafaxine glucuronide N,O-Didesmethylvenlafaxine N,O-Didesmethylvenlafaxine glucuronide N,N,O-Tridesmethylvenlafaxine Venlafaxine O2 NADH Formaldehyde NAD H2O O2 NADH N-Desmethylvenlafaxine Formaldehyde NAD H2O O2 NADH Formaldehyde NAD H2O O2 NADH Formaldehyde NAD H2O Heme Heme Heme Heme Heme Heme Heme Heme Blood-brain-barrier Endoplasmic Reticulum Membrane
Endoplasmic Reticulum SLC6A2 SLC6A4 ABCB1 CYP2D6 CYP2C19 CYP2C19 CYP3A4 CYP3A4 CYP2C19 CYP2C19 CYP2D6 Venlafaxine O- Desmethylvenlafaxine O- Desmethylvenlafaxine glucuronide N,O- Didesmethylvenlafaxine N,O- Didesmethylvenlafaxine glucuronide N,N,O- Tridesmethylvenlafaxine Venlafaxine Oxygen NADH Formaldehyde NAD Water Oxygen NADH N- Desmethylvenlafaxine Formaldehyde NAD Water Oxygen NADH Formaldehyde NAD Water Oxygen NADH Formaldehyde NAD Water
SLC6A2 SLC6A4 ABCB1 CYP2D6 CYP2C19 CYP2C19 CYP3A4 CYP3A4 CYP2C19 CYP2C19 CYP2D6 Venlafa O-Dmvf ODg NODt NODg NNOT Venlafa O2 NADH Formol NAD H2O O2 NADH NDmv Formol NAD H2O O2 NADH Formol NAD H2O O2 NADH Formol NAD H2O Heme Heme Heme Heme Heme Heme Heme Heme Blood-brain-barrier Endoplasmic Reticulum Membrane
Endoplasmic Reticulum SLC6A2 SLC6A4 ABCB1 CYP2D6 CYP2C19 CYP2C19 CYP3A4 CYP3A4 CYP2C19 CYP2C19 CYP2D6 Venlafa O-Dmvf ODg NODt NODg NNOT Venlafa O2 NADH Formol NAD H2O O2 NADH NDmv Formol NAD H2O O2 NADH Formol NAD H2O O2 NADH Formol NAD H2O