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Sodium/potassium- transporting ATPase subunit gamma ATPase, (Na+)/K+ transporting, beta 4 polypeptide K+ K+ Ca+ Sodium/potassium- transporting ATPase subunit beta-3 Beta-1 adrenergic receptor Tropomyosin alpha-1 chain Tropomyosin beta chain Beta-1 adrenergic receptor cAMP-dependent protein kinase type I-alpha regulatory subunit Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Ryanodine receptor 2 Muscarinic acetylcholine receptor M2 Cardiac phospholamban Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-2 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Kv channel- interacting protein 2 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Potassium channel subfamily K member 1 Sodium/calcium exchanger 1 Potassium/sodium hyperpolarization- activated cyclic nucleotide- gated channel 4 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Sodium/calcium exchanger 1 cAMP-dependent protein kinase catalytic subunit alpha Sodium/potassium- transporting ATPase subunit beta-1 Inward rectifier potassium channel 2 Sotalol Ca+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ Ca+ Ca+ Na+ Na+ Na+ Na+ K+ K+ Na+ Na+ Ca+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ ATP H2O Ca+ ADP Pi Ca+ Ca+ Troponin Troponin G-protein signalling cascade G-protein signalling cascade Muscle Contraction G protein- activated inward rectifier potassium channel 1 G protein- activated inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase Cardiac Muscle Skeletal Muscle Striated Muscle Cell Nucleus Mitochondrion Myofibril Sarcoplasmic Reticulum Myofibril Sarcolema Sarcoplasmic Reticulum Calcium binding to troponin displaces tropomyosin from the myosin binding sites on the actin filaments Myosin, with an ADP and phosphate attached, binds to actin to form a cross bridge. Myosin performs a powerstroke, drawing the actin filaments together. Many actin filaments pulled together at the same time leads to muscle contraction. Actin Filament Myosin Filament T-Tubule Depolarization Mitochondrion Single Sarcomere Functioning Unit
Mitochondria FXYD2 Unknown Potassium Potassium Calcium ATP1B3 ADRB1 TPM1 TPM2 ADRB1 PRKAR1A CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 PLN ATP2A2 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B2 KCNJ4 KCND3 KCNIP2 Unknown Unknown KCNQ1 KCNE1 KCNE2 ABCC8 KCNJ8 KCNJ11 Unknown KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G SLC8A1 PRKACA ATP1B1 KCNJ2 Sotalol Calcium Sodium Sodium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Calcium Calcium Sodium Sodium Sodium Sodium Potassium Potassium Sodium Sodium Calcium Calcium Calcium Calcium Calcium Sodium Sodium Adenosine triphosphate Water Calcium Adenosine diphosphate Phosphate Calcium Calcium Troponin Troponin G-protein signalling cascade G-protein signalling cascade Muscle Contraction KCNJ3 KCNJ5 KCNH2 ALG10B Created with Snap
FXYD2 K+ K+ Ca+ ATP1B3 ADRB1 TPM1 TPM2 ADRB1 PRKAR1A CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 PLN ATP2A2 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B2 KCNJ4 KCND3 KCNIP2 KCNQ1 KCNE1 KCNE2 ABCC8 KCNJ8 KCNJ11 KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G SLC8A1 PRKACA ATP1B1 KCNJ2 Slol Ca+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ Ca+ Ca+ Na+ Na+ Na+ Na+ K+ K+ Na+ Na+ Ca+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ ATP H2O Ca+ ADP Pi Ca+ Ca+ Troponi Troponi G-p s c G-p s c Mus Con KCNJ3 KCNJ5 KCNH2 ALG10B Cardiac Muscle Skeletal Muscle Striated Muscle Cell Nucleus Mitochondrion Myofibril Sarcoplasmic Reticulum Myofibril Sarcolema Sarcoplasmic Reticulum Calcium binding to troponin displaces tropomyosin from the myosin binding sites on the actin filaments Myosin, with an ADP and phosphate attached, binds to actin to form a cross bridge. Myosin performs a powerstroke, drawing the actin filaments together. Many actin filaments pulled together at the same time leads to muscle contraction. Actin Filament Myosin Filament T-Tubule Depolarization Mitochondrion Single Sarcomere Functioning Unit
Mitochondria FXYD2 K+ K+ Ca2+ ATP1B3 ADRB1 TPM1 TPM2 ADRB1 PRKAR1A CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 PLN ATP2A2 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B2 KCNJ4 KCND3 KCNIP2 KCNQ1 KCNE1 KCNE2 ABCC8 KCNJ8 KCNJ11 KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G SLC8A1 PRKACA ATP1B1 KCNJ2 Slol Ca2+ Na+ Na+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ K+ Ca2+ Ca2+ Na+ Na+ Na+ Na+ K+ K+ Na+ Na+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Na+ Na+ ATP H2O Ca2+ ADP Pi Ca2+ Ca2+ Troponi Troponi G-p s c G-p s c Mus Con KCNJ3 KCNJ5 KCNH2 ALG10B Created with Snap