PathWhiz

Pathway Description

Antipyrine Action Pathway

Homo sapiens

Drug Action Pathway

Antipyrine (also named Fenazone or Phenazone) is often used for testing the effect of other drugs on drug-metabolizing enzymes in the liver. Antipyrine can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. Decreased prostaglandin synthesis in many animal model's cell is caused by presence of antipyrine.

References

Antipyrine Pathway References

Vestal RE, Norris AH, Tobin JD, Cohen BH, Shock NW, Andres R: Antipyrine metabolism in man: influence of age, alcohol, caffeine, and smoking. Clin Pharmacol Ther. 1975 Oct;18(4):425-32.

Pubmed: 1164824

Feely J, Wood AJ: Effect of inhibitors of prostaglandin synthesis on hepatic drug clearance. Br J Clin Pharmacol. 1983 Jan;15(1):109-11.

Pubmed: 6849732

Arachidonic Acid Metabolism References

Lehninger, A.L. Lehninger principles of biochemistry (4th ed.) (2005). New York: W.H Freeman.

Vance, D.E., and Vance, J.E. Biochemistry of lipids, lipoproteins, and membranes (4th ed.) (2002) Amsterdam; Boston: Elsevier.

Salway, J.G. Metabolism at a glance (3rd ed.) (2004). Alden, Mass.: Blackwell Pub.

Kroetz DL, Zeldin DC: Cytochrome P450 pathways of arachidonic acid metabolism. Curr Opin Lipidol. 2002 Jun;13(3):273-83.

Pubmed: 12045397

Zeldin DC: Epoxygenase pathways of arachidonic acid metabolism. J Biol Chem. 2001 Sep 28;276(39):36059-62. doi: 10.1074/jbc.R100030200. Epub 2001 Jul 12.

Pubmed: 11451964

Ondrey FG: Arachidonic acid metabolism: a primer for head and neck surgeons. Head Neck. 1998 Jul;20(4):334-49.

Pubmed: 9588707

Sigal E: The molecular biology of mammalian arachidonic acid metabolism. Am J Physiol. 1991 Feb;260(2 Pt 1):L13-28. doi: 10.1152/ajplung.1991.260.2.L13.

Pubmed: 1899973

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		11,12,15-THETA
		11,12-DiHETrE
		11,12-Epoxyeicosatrienoic acid
		11,14,15-THETA
		11-Dehydro-thromboxane B2
		11-Epi-PGF2a
		11H-14,15-EETA
		12(R)-HETE
		12(R)-HPETE
		12(S)-HETE
		12(S)-HPETE
		12-KETE
		12-Keto-leukotriene B4
		14,15-DiHETrE
		14,15-Epoxy-5,8,11-eicosatrienoic acid
		15(S)-HETE
		15(S)-HPETE
		15-Deoxy-d-12,14-PGJ2
		15H-11,12-EETA
		16(R)-HETE
		19(S)-HETE
		2,3-Dinor-8iso prostaglandin F1α
		2,3-Dinor-8iso prostaglandin F2α
		20-Carboxy-leukotriene B4
		20-Hydroxy-leukotriene B4
		20-Hydroxyeicosatetraenoic acid
		5,6-DHET
		5,6-Epoxy-8,11,14-eicosatrienoic acid
		5,6-Epoxytetraene
		5-HETE
		5-HPETE
		5-KETE
		6-Keto-prostaglandin F1a
		6-Ketoprostaglandin E1
		8(S)-HPETE
		8,9-DiHETrE
		8,9-Epoxyeicosatrienoic acid
		8-HETE
		8-Isoprostane
		Antipyrine
		Arachidonic acid
		Calcium
		Fe3+
		Glutathione
		Heme
		L-Glutamic acid
		Leukotriene A4
		Leukotriene B4
		Leukotriene C4
		Leukotriene D4
		LysoPC(14:0/0:0)
		Magnesium
		NADP
		NADPH
		Oxidized glutathione
		Oxygen
		PC(14:0/20:4(5Z,8Z,11Z,14Z))
		Prostaglandin A2
		Prostaglandin B2
		Prostaglandin D2
		Prostaglandin E2
		Prostaglandin F2a
		Prostaglandin G2
		Prostaglandin H2
		Prostaglandin I2
		Prostaglandin J2
		Prostaglandin-c2
		Thromboxane A2
		Thromboxane B2
		Water
		Zinc (II) ion
		δ-12-Prostaglandin J2

Visualize Protein Data

		Aldo-keto reductase family 1 member C3
		Arachidonate 12-lipoxygenase, 12R-type
		Arachidonate 12-lipoxygenase, 12S-type
		Arachidonate 15-lipoxygenase
		Arachidonate 15-lipoxygenase B
		Arachidonate 5-lipoxygenase
		Bifunctional epoxide hydrolase 2
		Carbonyl reductase [NADPH] 1
		Cytochrome P450 2B6
		Cytochrome P450 2C8
		Cytochrome P450 2E1
		Cytochrome P450 2J2
		Cytochrome P450 2U1
		Cytochrome P450 4A11
		Cytochrome P450 4F8
		Cytosolic phospholipase A2 beta
		Gamma-glutamyltranspeptidase 1
		Glutathione peroxidase 1
		Leukotriene A-4 hydrolase
		Leukotriene C4 synthase
		Leukotriene-B(4) omega-hydroxylase 1
		Leukotriene-B(4) omega-hydroxylase 2
		Prostacyclin synthase
		Prostaglandin E synthase
		Prostaglandin G/H synthase 1
		Prostaglandin G/H synthase 2
		Prostaglandin-H2 D-isomerase
		Prostamide/prostaglandin F synthase
		Thromboxane-A synthase

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