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Pathway Description
Rolitetracycline Action Pathway
Homo sapiens
Drug Action Pathway
Rolitetracycline is a broad spectrum second antibiotic formed by the N-aminomethylation of the carboxamide function of tetracycline. Classified as a second generation tetracycline due to it’s semi-synthesis, rolitetracycline like tetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This prevents tRNA from interacting with the ribosome ultimately halting the addition of amino acids to peptide chains used in protein synthesis.
References
Rolitetracycline Pathway References
Fuoco D: Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs. Antibiotics (Basel). 2012 Jun 12;1(1):1-13. doi: 10.3390/antibiotics1010001.
Pubmed: 27029415
Butterfield AG, Hughes DW, Wilson WL, Pound NJ: Simultaneous high-speed liquid chromatographic determination of tetracycline and rolitetracycline in rolitetracycline formulations. J Pharm Sci. 1975 Feb;64(2):316-20. doi: 10.1002/jps.2600640228.
Pubmed: 1127588
Chopra I: New developments in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors. Drug Resist Updat. 2002 Jul-Aug;5(3-4):119-25.
Pubmed: 12237079
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